Jose Javier Bravo Cordero, PhD
- ASSISTANT PROFESSOR | Medicine, Hematology and Medical Oncology
Research Topics:
Cancer, Cell Adhesion, Cell Biology, Cell Motility, Chemokines, Chemotaxis, Cytoskeleton, Extracellular Matrix, Image Analysis, Imaging, Macrophage, Metastasis, Migration, Molecular Biology, Two-Photon ImagingDr. Bravo-Cordero was trained as a cell biologist and molecular biologist. He earned his bachelor’s degree at Autonoma University of Madrid (Spain) and his PhD in Cancer Biology at the Spanish National Cancer Institute (CNIO, Spain) working on mechanisms of tumor cell invasion in 3D collagen matrices by using high-resolution imaging.
During his postdoctoral training, he extended his expertise in breast cancer metastasis by applying unique imaging technologies such as FRET microscopy and intravital imaging at the Albert Einstein College of Medicine in New York. He studied the spatiotemporal activation of RhoGTPases during invasion by using a series of imaging tools (FRET biosensors) to visualize GTPase activation in real time in living cells.
Dr. Bravo-Cordero's expertise ranges from microscopy (FRET microscopy, in vivo imaging) to cell biology and mouse models. His laboratory is investigating the mechanisms of tumor cell dissemination and metastasis of breast cancer by applying high-resolution imaging techniques.
In September 2015, he joined the Division of Hematology and Oncology, the Tisch Cancer Institute and the Microscopy CORE at Icahn School of Medicine at Mount Sinai as an assistant professor.
Multi-Disciplinary Training Areas
Cancer Biology [CAB], Development, Regeneration, and Stem Cells [DRS]Valenzuela-Iglesias A, Sharma VP, Beaty BT, Ding Z, Gutierrez-Millan LE, Roy P, Condeelis JS, Bravo-Cordero JJ. Profilin1 regulates invadopodium maturation in human breast cancer cells. European journal of cell biology 2015 Feb; 94(2).
Beaty BT, Wang Y, Bravo-Cordero JJ, Sharma VP, Miskolci V, Hodgson L, Condeelis J. Talin regulates moesin-NHE-1 recruitment to invadopodia and promotes mammary tumor metastasis. The Journal of cell biology 2014 Jun; 205(5).
Moshfegh Y, Bravo-Cordero JJ, Miskolci V, Condeelis J, Hodgson L. A Trio-Rac1-Pak1 signalling axis drives invadopodia disassembly. Nature cell biology 2014 Jun; 16(6).
Bravo-Cordero JJ, Hodgson L, Condeelis JS. Spatial regulation of tumor cell protrusions by RhoC. Cell adhesion & migration 2014; 8(3).
Donnelly SK, Bravo-Cordero JJ, Hodgson L. Rho GTPase isoforms in cell motility: Don't fret, we have FRET. Cell adhesion & migration 2014; 8(6).
Spiering D, Bravo-Cordero JJ, Moshfegh Y, Miskolci V, Hodgson L. Quantitative ratiometric imaging of FRET-biosensors in living cells. Methods in cell biology 2013; 114.
Roh-Johnson M, Bravo-Cordero JJ, Patsialou A, Sharma VP, Guo P, Liu H, Hodgson L, Condeelis J. Macrophage contact induces RhoA GTPase signaling to trigger tumor cell intravasation. Oncogene 2014 Aug; 33(33).
Bravo-Cordero JJ, Sharma VP, Roh-Johnson M, Chen X, Eddy R, Condeelis J, Hodgson L. Spatial regulation of RhoC activity defines protrusion formation in migrating cells. Journal of cell science 2013 Aug; 126(Pt 15).
Bravo-Cordero JJ, Magalhaes MA, Eddy RJ, Hodgson L, Condeelis J. Functions of cofilin in cell locomotion and invasion. Nature reviews. Molecular cell biology 2013 Jul; 14(7).
Bravo-Cordero JJ, Moshfegh Y, Condeelis J, Hodgson L. Live cell imaging of RhoGTPase biosensors in tumor cells. Methods in molecular biology (Clifton, N.J.) 2013; 1046.
Magalhaes MA, Larson DR, Mader CC, Bravo-Cordero JJ, Gil-Henn H, Oser M, Chen X, Koleske AJ, Condeelis J. Cortactin phosphorylation regulates cell invasion through a pH-dependent pathway. The Journal of cell biology 2011 Nov; 195(5).
Bravo-Cordero JJ, Hodgson L, Condeelis J. Directed cell invasion and migration during metastasis. Current opinion in cell biology 2012 Apr; 24(2).
Patsialou A, Bravo-Cordero JJ, Wang Y, Entenberg D, Liu H, Clarke M, Condeelis JS. Intravital multiphoton imaging reveals multicellular streaming as a crucial component of in vivo cell migration in human breast tumors. Intravital 2013 Apr; 2(2).
Bravo-Cordero JJ, Oser M, Chen X, Eddy R, Hodgson L, Condeelis J. A novel spatiotemporal RhoC activation pathway locally regulates cofilin activity at invadopodia. Current biology : CB 2011 Apr; 21(8).
Beaty BT, Sharma VP, Bravo-Cordero JJ, Simpson MA, Eddy RJ, Koleske AJ, Condeelis J. β1 integrin regulates Arg to promote invadopodial maturation and matrix degradation. Molecular biology of the cell 2013 Jun; 24(11).
Marrero-Diaz R, Bravo-Cordero JJ, Megías D, García MA, Bartolomé RA, Teixido J, Montoya MC. Polarized MT1-MMP-CD44 interaction and CD44 cleavage during cell retraction reveal an essential role for MT1-MMP in CD44-mediated invasion. Cell motility and the cytoskeleton 2009 Jan; 66(1).
Oser M, Yamaguchi H, Mader CC, Bravo-Cordero JJ, Arias M, Chen X, Desmarais V, van Rheenen J, Koleske AJ, Condeelis J. Cortactin regulates cofilin and N-WASp activities to control the stages of invadopodium assembly and maturation. The Journal of cell biology 2009 Aug; 186(4).
Escobar B, de Cárcer G, Fernández-Miranda G, Cascón A, Bravo-Cordero JJ, Montoya MC, Robledo M, Cañamero M, Malumbres M. Brick1 is an essential regulator of actin cytoskeleton required for embryonic development and cell transformation. Cancer research 2010 Nov; 70(22).
Oser M, Mader CC, Gil-Henn H, Magalhaes M, Bravo-Cordero JJ, Koleske AJ, Condeelis J. Specific tyrosine phosphorylation sites on cortactin regulate Nck1-dependent actin polymerization in invadopodia. Journal of cell science 2010 Nov; 123(Pt 21).
Mader CC, Oser M, Magalhaes MA, Bravo-Cordero JJ, Condeelis J, Koleske AJ, Gil-Henn H. An EGFR-Src-Arg-cortactin pathway mediates functional maturation of invadopodia and breast cancer cell invasion. Cancer research 2011 Mar; 71(5).
Physicians and scientists on the faculty of the Icahn School of Medicine at Mount Sinai often interact with pharmaceutical, device and biotechnology companies to improve patient care, develop new therapies and achieve scientific breakthroughs. In order to promote an ethical and transparent environment for conducting research, providing clinical care and teaching, Mount Sinai requires that salaried faculty inform the School of their relationships with such companies.
Dr. Bravo Cordero did not report having any of the following types of financial relationships with industry during 2017 and/or 2018: consulting, scientific advisory board, industry-sponsored lectures, service on Board of Directors, participation on industry-sponsored committees, equity ownership valued at greater than 5% of a publicly traded company or any value in a privately held company. Please note that this information may differ from information posted on corporate sites due to timing or classification differences.
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