Kurt Hirschhorn, MD
- PROFESSORIAL LECTURER | Pediatrics
- PROFESSORIAL LECTURER | Genetics and Genomic Sciences
- PROFESSORIAL LECTURER | Medicine
Dr. Kurt Hirschhorn is the Professor Emeritus of Pediatrics, Genetics and Medicine, and Chairman Emeritus of Pediatrics. He received his medical degree in 1954 from New York University School of Medicine. He was elected to both Phi Beta Kappa and Alpha Omega Alpha. He served his residency in internal medicine at Bellevue Hospital, New York, and remained there as a Fellow in Metabolic Diseases and then had a Fellowship in Human Genetics in Uppsala, Sweden. He was awarded a master of science in Internal Medicine and Genetics in 1958, when he became Assistant Professor and then Associate Professor of Medicine at New York University School of Medicine. He became Professor of Pediatrics at Mount Sinai School of Medicine in New York in 1966 where he established a new Medical Genetics Program. From 1968 to 1976 he was the Arthur J. and Nellie Z. Cohen Professor of Genetics at Mount Sinai School of Medicine. In 1977, he became the Herbert H. Lehman Professor and Chairman of the Department of Pediatrics at Mount Sinai School of Medicine and Pediatrician‑in‑Chief at Mount Sinai Hospital. In 1995, he stepped down from the chairmanship and returned to research in human genetics as a Professor of Pediatrics, Human Genetics and Medicine.
Dr. Hirschhorn continues to be actively involved in research and in the clinical practice of medical genetics. His work includes research and application of the various subdisciplines of genetics including cytogenetics, biochemical genetics and molecular genetics. He is one of the founding members of The Hastings Center for Biomedical Ethics and chaired the Medical Board Ethics Committee at Mount Sinai Hospital for 30 years. His longstanding interest and leadership in medical genetics has resulted in the publication of more than 400 articles. He has received many national and international honors, including membership in the Institute of Medicine of the National Academy of Sciences.
Victor A. McKusick Leadership Award
The John Howland Award for Distinguished Service to Pediatrics
Award for Excellence in Human Genetics Education
William Allan Award
The Solomon A. Berson Medical Alumni Achievement Award in Clinical Science
a. Use of molecular and cytogenetic techniques such as in situ hybridization, comparative genomic hybridization (CGH) and/or FISH for refined diagnosis and mapping of genetic loci.
b. Chromosomal Abnormalities: Use of chromosome elongation (late prophase preparations), newer banding techniques and FISH to characterize structural alterations in chromosomes of parents with congenital malformation syndromes and in couples with infertility/recurrent miscarriages.
2. Clinical Genetics/Prenatal Diagnosis:
a. Application of genetic technology to the diagnosis, management and treatment of patients and families with genetic disease.
b. Delineation of new syndromes.
c. Genetic counseling methodology and assessment.
d. Prenatal Genetics: Studies designed to develop new and improved methods for the prenatal diagnosis and/or treatment of chromosomal, biochemical or multifactorial disorders. Preimplantation diagnosis by CGH to detect chromosomal abnormalities in polar bodies and 8-cell embryos. Application of molecular diagnostic techniques for precise diagnosis of disorders whose genes are expressed in specific tissues. Analysis of fetal cells in maternal blood and in the endocervical canal.
Levy B, Hirschhorn K. Tetrasomy 15q26: a distinct syndrome or Shprintzen-Goldberg syndrome phenocopy? . Genet. In Med 2012; 14: 811-818 .
Rhodes R, Hirschhorn K. De minimis risk: a proposal for a new category of research risk. . Am. J. Bioeth 2011; 11: 1-7.
Edelmann L, Hirschhorn K. Clinical utility of array CGH for the detection of chromosomal imbalances associated with mental retardation and multiple congenital anomalies.. Ann. N.Y. Acad. Sci. 2009; 1151: 157-166 .
Edelmann L, Hirschhorn K. Multiple hemangiomas in a patient with a t(3q;4p) translocation: an infrequent association with Wolf-Hirschhorn Syndrome. . Am. J. Med. Genet 2008; 146: 219-224 .
Levy B, Hirschhorn K. The incidence and spectrum of chromosome abnormalities in spontaneous abortions – New insights from a 12-year study.. Genet. in Med 2005; 7: 251-263 .