Lewis Kaufman, MD
img_Lewis Kaufman
PROFESSOR | Medicine, Nephrology
Are you a patient?
Specialties
Nephrology, Internal Medicine
Renal development
The sidekicks are highly expressed in many organs during embryogenesis. In the developing kidney, they are expressed throughout the branching ureteric bud. By using an siRNA based approach, we are studying the role of the sidekick proteins during nephrogenesis and how the sidekicks interact with other critical mediators of ureteric bud branching.
Podocyte dysfunction
We study the glomerular podocyte, a critical cell in forming the kidney's ultrafiltration barrier. Podocyte injury occurs in all forms of proteinuric renal disease and is critical in mediating progression of renal failure. We have identified the sidekick gene family as being highly upregulated in podocytes in HIV-associated nephropathy (HIVAN). We have shown that the sidekicks function as homophilic adhesion molecules and that their over-expression in HIVAN alters how adjacent podocytes interact. We are interested in understanding how the sidekicks contribute to renal failure pathogenesis in both HIVAN and in other renal diseases.

MD, State University of NY at Stony Brook School of Medicine

Mount Sinai School of Medicine

Mount Sinai School of Medicine

Mount Sinai School of Medicine

BA, Columbia University

MD, State University of New York at Stony Brook

Residency, Internal Medicine, Mount Sinai Hospital

Fellowship, Nephrology, Mount Sinai Hospital

Certifications

American Board of Internal Medicine

Physicians and scientists on the faculty of the Icahn School of Medicine at Mount Sinai often interact with pharmaceutical, device, biotechnology companies, and other outside entities to improve patient care, develop new therapies and achieve scientific breakthroughs. In order to promote an ethical and transparent environment for conducting research, providing clinical care and teaching, Mount Sinai requires that salaried faculty inform the School of their outside financial relationships.

Dr. Kaufman has not yet completed reporting of Industry relationships.

Mount Sinai's faculty policies relating to faculty collaboration with industry are posted on our website. Patients may wish to ask their physician about the activities they perform for companies.