Luca Lambertini, PhD
- ASSISTANT PROFESSOR | Medicine, Endocrinology, Diabetes and Bone Disease
- ASSISTANT PROFESSOR | Obstetrics, Gynecology and Reproductive Science
Dr. Luca Lambertini is an Assistant Professor of Preventive Medicine and Obstetrics, Gynecology and Reproductive Science (OB/GYN) at Mount Sinai School of Medicine (MSSM). Dr. Lambertini received his PhD in Molecular Biology from the University of Bologna, Italy in 1995. Dr. Lambertini then completed a 1 and ½ year of postdoctoral training in molecular biology before beginning the studies for a Master of Science in Industrial Hygiene supported by EFESO and Regione Emilia-Romagna (Italy) with funding from the European Union. He completed his master in 1998 in Forlì, Italy. The same year Dr. Lambertini joined the Ramazzini Institute, an internationally recognized leading institution located in Bentivoglio, Italy, working on the study of the long-term effects on health of the exposure to putative carcinogenic chemical/physical agents in experimental animal models. During this period Dr. Lambertini also worked in analytic epidemiology unit investigating the disease profile of workers exposed to known carcinogens. From year 2002 to 2004 Dr. Lambertini undertook a fellowship at the National Institute of Environmental Health Sciences (NIEHS) one of the National Institutes of Health (NIH) institutions located in Research Triangle Park, NC, USA. During his fellowship Dr. Lambertini focused on molecular investigations for the determination of the genetic effects of the exposure to know carcinogens. He then returned to the Ramazzini Institute where he developed the platform for the implementation of molecular studies on the experimental animal model of the institution. In year 2006 Dr. Lambertini joined MSSM for a 2-year fellowship for studying the developmental origin of chronic disorders. During this period Dr. Lambertini developed his activity on human placental tissue. He also earned his Master of Public Health at MSSM in year 2008. Dr. Lambertini was then hired by the Department of Preventive Medicine and, thanks to his work on placenta with the MSSM OB/GYN Department he was granted his secondary appointment.
PhD, Università degli Studi di Bologna
MSc, Ente di Formazione per l’Economia Sociale (EFESO) - Regione Emilia Romagna
MPH, Mount Sinai School of Medicine
Dr. Lambertini works in the Environmental Health Lab of the Preventive Medicine Department. His research is oriented toward the identification and characterization of biomarkers of improper fetal development leading to the manifestation of chronic and developmental disorders in children.
Dr. Lambertini’s centers around the following main areas:
1. Genomic Imprinting. This epigenetically driven phenomenon is governed by an intricate network of epigenetic signals that contribute to the allele-specific expression of a limited number of genes according to the parent-of-origin. Perturbation of the imprinting and/or expression profiles of these genes have been linked to pregnancy outcomes, like mainly growth restriction, and disorders like obesity and neurodevelopmental syndromes in children. Dr. Lambertini studies genomic imprinting in human placenta by using a highly sensitive technique that measures loss of imprinting (LOI) at the RNA level by determining the relative amount of RNA transcribed by each allele for a subset of imprinted genes. By using an allele-specific PCR approach this technique allows measuring the effects of all epigenetic effector acting on regulating the imprinting profile. Dr. Lambertini worked on establishing the correlation between LOI perturbation and growth restriction as well as imprinted gene expression dysregulation and neurodevelopmental status at birth.
2. long non-coding RNAs (lncRNAs). Non-coding RNA, transcribed in high amount accordingly with the complexity of the organism, represent double the number of RNAs transcribed by the known genes of the human genome. Their role is poorly understood and, beside micro RNAs almost nothing is know about other non-coding RNAs like lncRNAs. These transcripts are longer than 500 bp and have been hypothesized to work as regulator of the DNA eu/ethero-chromatic status. Between them several lncRNAs have been found to critically affect different aspects of differentiation and to drive some key developmental phases of the embryo. Dr. Lambertini developed a project intended to identify all lncRNAs expressedin placenta, monitor their expression in fetal growth and development.
3. Mitochondrial DNA (mtDNA) methylation. Recently the role of methylation on the regulation of the mtDNA functioning became evident. These cellular organelles are fundamental for adapting the metabolic rates of our tissues and organs to different needs. Mitochondria also play a critical role in fetoplacental; development by sustaining the peculiar metabolic rate of this temporary organ and they also participate on supporting the brain growth. Dr. Lambertini is conducting a project intended to deep sequence the placental mitochondrial DNA from normal and growth restricted placentas in order to pinpoint differentially methylated regions that could be the signature of an altered fetal development.
4. Windows of Susceptibility. Chronic and developmental disorders in children include pathologies that span from asthma and obesity, to neurodevelopmental syndromes and to cancer. The recognition is increasing that supports the understanding that such disorders have their bases in an improper fetal development. During the embryo development there indeed exist windows of susceptibility that can alter the correct growth and lead to the manifestation of such a plethora of disorders. In collaboration with Drs. Jia Chen and Susan Teitelbaum, Dr. Lambertini is investigating perturbations of the epigenetic setup in experimental animals exposed to chemicals with endocrine disrupting potential commonly found in the environment of human life. Correlation will be sought between these epigenetic dysregulations and mammary cancer as well as other indicator of alteration of the developmental trajectory of the fetus.
5. The Policystic Ovary Syndrome (PCOS) Model. PCOS is an ideal model to study the dysregulations of the epigenetic profile leading to chronic disorders in children. Women affected by PCOS deliver infants with a high risk to develop metabolic syndrome and become obese. Working in collaboration with Drs. Yaron Tomer, Nathan Kase and Joanne Stone, Dr. Lambertini is working by participating in the profiling of the epigenetic status of a limited number of PCOS women before and during pregnancy and then analyze the progeny for the same parameters. Babies born from these pregnancies will be further followed up to assess their health status to correlate with the experimental findings.
6. Mount Sinai Pregnancy Biobank (MSPB). Research projects from different MSSM Departments including Preventive Medicine and OB/GYN, would greatly benefit from the availability of placental tissue and umbilical cord blood to elaborate marker of improper fetal development. In this framework, Dr. Lambertini collaborated to the development and now leads the project for the implementation of the MSPB that is by to be activated and will collect such samples linked to the patient’s clinical information stored at MSSM. Samples will be available to the whole MSSM scientific community and follow-up on children will also be available on the basis of the protocol for each project that will use MSPB samples.
7. Other projects. Dr. Lambertini is also involved in the National Children’s Study (NCS), is developing a patent for a new placenta sampling tool and collaborate with Dr. Stone to elaborate experimental research projects for the Maternal-Fetal Medicine fellows of the OB/GYN Department.
Soffritti M, Belpoggi F, Degli Esposti D, Lambertini L, Tibaldi E, Rigano A. First experimental demonstration of the multipotential carcinogenic effects of aspartame administered in the feed to Sprague-Dawley rats. Environmental health perspectives 2006 Mar; 114(3).
Soffritti M, Belpoggi F, Degli Esposti D, Lambertini L. Results of a long-term carcinogenicity bioassay on Sprague-Dawley rats exposed to sodium arsenite administered in drinking water. Annals of the New York Academy of Sciences 2006 Sep; 1076.
Lambertini L, Diplas AI, Lee MJ, Sperling R, Chen J, Wetmur J. A sensitive functional assay reveals frequent loss of genomic imprinting in human placenta. Epigenetics : official journal of the DNA Methylation Society 2008 Sep; 3(5).
Diplas AI, Lambertini L, Lee MJ, Sperling R, Lee YL, Wetmur J, Chen J. Differential expression of imprinted genes in normal and IUGR human placentas. Epigenetics : official journal of the DNA Methylation Society 2009 May; 4(4).
Diplas AI, Hu J, Lee MJ, Ma YY, Lee YL, Lambertini L, Chen J, Wetmur JG. Demonstration of all-or-none loss of imprinting in mRNA expression in single cells. Nucleic acids research 2009 Nov; 37(21).
Pozharny Y, Lambertini L, Clunie G, Ferrara L, Lee MJ. Epigenetics in women's health care. The Mount Sinai journal of medicine, New York; 77(2).
Pozharny Y, Lambertini L, Clunie G, Ferrara L, Lee MJ. Epigenetics in women's health care. The Mount Sinai journal of medicine, New York; 77(2).
Pozharny Y, Lambertini L, Ma Y, Ferrara L, Litton CG, Diplas A, Jacobs AR, Chen J, Stone JL, Wetmur J, Lee MJ. Genomic loss of imprinting in first-trimester human placenta. American journal of obstetrics and gynecology 2010 Apr; 202(4).
Lambertini L, Lee TL, Chan WY, Lee MJ, Diplas A, Wetmur J, Chen J. Differential methylation of imprinted genes in growth-restricted placentas. Reproductive sciences (Thousand Oaks, Calif.) 2011 Nov; 18(11).
Landrigan PJ, Lambertini L, Birnbaum LS. A Research Strategy to Discover the Environmental Causes of Autism and Neurodevelopmental Disabilities. Environ Health Perspect 2011;.
Lambertini L, Lee MJ, Marsit CJ, Chen J. Genomic Imprinting in Human Placenta. In Zheng J Ed. The Human Placenta. InTech Open Access Publisher 2011;.
Marsit CJ, Lambertini L, Maccani M, Koestler D, Houseman EA, Gangne L, Padbury JF, Lester BM, Chen J. Placenta Imprinted Gene Expression Association of Infant Neurobehavior. J Pediatr 2011;.
Manservisi F, Gopalakrishnan K, Tibaldi E, Hysi A, Iezzi M, Lambertini L, Teitelbaum S, Chen J, Belpoggi F. Effect of maternal exposure to endocrine disrupting chemicals on reproduction and mammary gland development in female sprague-dawley rats. Reproductive toxicology (Elmsford, N.Y.) 2014 Dec;.
Jayaprakash AD, Benson EK, Gone S, Liang R, Shim J, Lambertini L, Toloue MM, Wigler M, Aaronson SA, Sachidanandam R. Stable heteroplasmy at the single-cell level is facilitated by intercellular exchange of mtDNA. Nucleic acids research 2015 Feb;.
Kappil M, Lambertini L, Chen J. Environmental Influences on Genomic Imprinting. Current environmental health reports 2015 Jun; 2(2).
Teitelbaum SL, Li Q, Lambertini L, Belpoggi F, Manservisi F, Falcioni L, Bua L, Silva MJ, Ye X, Calafat AM, Chen J. Paired Serum and Urine Concentrations of Biomarkers of Diethyl Phthalate, Methyl Paraben, and Triclosan in Rats. Environmental health perspectives 2015 Jun;.
Kappil MA, Green BB, Armstrong DA, Sharp AJ, Lambertini L, Marsit CJ, Chen J. Placental Expression Profile of Imprinted Genes Impacts Birth Weight. Epigenetics : official journal of the DNA Methylation Society 2015 Jul;.
Green BB, Kappil M, Lambertini L, Armstrong DA, Guerin DG, Sharp AJ, Lester BM, Chen J, Marsit CJ. Expression of imprinted genes in placenta is associated with infant neurobehavioral development. Epigenetics : official journal of the DNA Methylation Society 2015 Jul;.
Li Q, Kappil MA, Li A, Dassanayake PS, Darrah TH, Friedman AE, Friedman M, Lambertini L, Landrigan P, Stodgell CJ, Xia Y, Nanes JA, Aagaard KM, Schadt EE, Murray JC, Clark EB, Dole N, Culhane J, Swanson J, Varner M, Moye J, Kasten C, Miller RK, Chen J. Exploring the associations between microRNA expression profiles and environmental pollutants in human placenta from the National Children's Study (NCS). Epigenetics 2015 Aug;.
Lambertini L, Chen J, Nomura Y. Mitochondrial Gene Expression Profiles Are Associated with Maternal Psychosocial Stress in Pregnancy and Infant Temperament. PloS one 2015 Sep; 10(9).
Kappil MA, Li Q, Li A, Dassanayake PS, Xia Y, Nanes JA, Landrigan PJ, Stodgell CJ, Aagaard KM, Schadt EE, Dole N, Varner M, Moye J, Kasten C, Miller RK, Ma Y, Chen J, Lambertini L. In utero exposures to environmental organic pollutants disrupt epigenetic marks linked to fetoplacental development. Environmental epigenetics 2016 Mar; 2(1).
Hu J, Raikhel V, Gopalakrishnan K, Fernandez-Hernandez H, Lambertini L, Manservisi F, Falcioni L, Bua L, Belpoggi F, L Teitelbaum S, Chen J. Effect of postnatal low-dose exposure to environmental chemicals on the gut microbiome in a rodent model. Microbiome 2016 Jun; 4(1).
Lambertini L, Byun HM. Mitochondrial Epigenetics and Environmental Exposure. Current environmental health reports 2016 Jun;.
Mella MT, Kohari K, Jones R, Peña J, Ferrara L, Stone J, Lambertini L. Mitochondrial gene expression profiles are associated with intrahepatic cholestasis of pregnancy. Placenta 2016 Sep; 45.
Gopalakrishnan K, Teitelbaum SL, Lambertini L, Wetmur J, Manservisi F, Falcioni L, Panzacchi S, Belpoggi F, Chen J. Changes in mammary histology and transcriptome profiles by low-dose exposure to environmental phenols at critical windows of development. Environmental research 2017 Jan; 152.
Nomura Y, John RM, Janssen AB, Davey C, Finik J, Buthmann J, Glover V, Lambertini L. Neurodevelopmental consequences in offspring of mothers with preeclampsia during pregnancy: underlying biological mechanism via imprinting genes. Archives of gynecology and obstetrics 2017 Jun; 295(6).
Litzky JF, Deyssenroth MA, Everson TM, Armstrong DA, Lambertini L, Chen J, Marsit CJ. Placental Imprinting Variation Associated with Assisted Reproductive Technologies and Subfertility. Epigenetics 2017 Jun;.
Deyssenroth MA, Peng S, Hao K, Lambertini L, Marsit CJ, Chen J. Whole-transcriptome analysis delineates the human placenta gene network and its associations with fetal growth. BMC genomics 2017 Jul; 18(1).
Litzky JF, Deyssenroth MA, Everson TM, Armstrong DA, Lambertini L, Chen J, Marsit CJ. Placental imprinting variation associated with assisted reproductive technologies and subfertility. Epigenetics 2017 Aug; 12(8).
Peng S, Deyssenroth MA, Di Narzo AF, Lambertini L, Marsit CJ, Chen J, Hao K. Expression quantitative trait loci (eQTLs) in human placentas suggest developmental origins of complex diseases. Human molecular genetics 2017 Sep; 26(17).
Kingsley SL, Deyssenroth MA, Kelsey KT, Awad YA, Kloog I, Schwartz JD, Lambertini L, Chen J, Marsit CJ, Wellenius GA. Maternal residential air pollution and placental imprinted gene expression. Environment international 2017 Sep; 108.
Wang H, Bender A, Wang P, Karakose E, Inabnet WB, Libutti SK, Arnold A, Lambertini L, Stang M, Chen H, Kasai Y, Mahajan M, Kinoshita Y, Fernandez-Ranvier G, Becker TC, Takane KK, Walker LA, Saul S, Chen R, Scott DK, Ferrer J, Antipin Y, Donovan M, Uzilov AV, Reva B, Schadt EE, Losic B, Argmann C, Stewart AF. Insights into beta cell regeneration for diabetes via integration of molecular landscapes in human insulinomas. Nature communications 2017 Oct; 8(1).
Lambertini L, Saul SR, Copperman AB, Hammerstad SS, Yi Z, Zhang W, Tomer Y, Kase N. Intrauterine Reprogramming of the Polycystic Ovary Syndrome: Evidence from a Pilot Study of Cord Blood Global Methylation Analysis. Frontiers in endocrinology 2017 Dec; 8.
Everson TM, Punshon T, Jackson BP, Hao K, Lambertini L, Chen J, Karagas MR, Marsit CJ. Cadmium-Associated Differential Methylation throughout the Placental Genome: Epigenome-Wide Association Study of Two U.S. Birth Cohorts. Environmental health perspectives 2018 Jan; 126(1).
Zhang W, Qian L, Deyssenroth M, Lambertini L, Finik J, Ham J, Huang Y, Tsuchiya KJ, Pehme P, Buthmann J, Yoshida S, Chen J, Nomura Y. Timing of Prenatal Exposure to Trauma and Altered Placental Expressions of HPA-Axis Genes and Genes Driving Neurodevelopment. Journal of neuroendocrinology 2018 Feb;.
Litzky JF, Deyssenroth MA, Everson TM, Lester BM, Lambertini L, Chen J, Marsit CJ. Prenatal exposure to maternal depression and anxiety on imprinted gene expression in placenta and infant neurodevelopment and growth. Pediatric research 2018 Apr;.
Deyssenroth MA, Gennings C, Liu SH, Peng S, Hao K, Lambertini L, Jackson BP, Karagas MR, Marsit CJ, Chen J. Intrauterine multi-metal exposure is associated with reduced fetal growth through modulation of the placental gene network. Environment international 2018 Aug; 120.
Jones R, Peña J, Mystal E, Marsit C, Lee MJ, Stone J, Lambertini L. Mitochondrial and glycolysis-regulatory gene expression profiles are associated with intrauterine growth restriction. The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians 2018 Sep;.