Madhu Mazumdar, PhD
- DIRECTOR, INSTITUTE FOR HEALTH CARE DELIVERY SCIENCE
- PROFESSOR | Population Health Science and Policy
- PROFESSOR | Orthopedics
Dr. Mazumdar developed methodologies for detecting publication bias in meta-analysis; for adjusting selection bias in clinical trials; for allowing interim looks at data in clinical trials comparing diagnostic tests; for developing and validating quality of life questionnaire; and for estimating misclassification rate of responders when oncologic response criteria were changed. Her collaborative research resulted in personalized treatment regimen for various cancer types and orthopedic surgeries. Her work also changed guidelines for staging cancer and practice guidelines for use of anesthetics. She developed innovative interdisciplinary educational and research programs, in collaboration with various clinical departments that increased productivity through grantsmanship and augmented clinical revenue through improved care delivery. Working within inter-disciplinary teams, she has trained more than 50 biostatisticians, epidemiologists, and clinical researchers, many of whom are leading quantitative science units today.
MA, University of Delhi
MS, University of Pittsburgh
PhD, Penn State University
Fellowship, Drexel University
Team Science Award
Methodology Areas: Meta-analysis, Comparative Effectiveness Research, Clinical Trial Design, Prognostic and Predictive modeling,
Clinical Research Areas: Oncology, Anesthesiology, Radiology, Surgery
Biostatistics Module, MS in Healthcare Delivery Science and Leadership, ISMMS
Clinical Trials Design Workshop: Organized by the Radiological Society of North America, a Clinical Research Training Institute Summer Workshop: Organized by the American Society of Hematology
Cozowicz C, Olson A, Poeran J, Mörwald EE, Zubizarreta N, Girardi FP, Hughes AP, Mazumdar M, Memtsoudis SG. Opioid prescription levels and postoperative outcomes in orthopedic surger. Pain 2017 Dec; 158(12): 2422-2430.
Hiensch R, Poeran J, Saunders-Hao P, Adams V, Powell CA, Glasser A, Mazumdar M, Patel G. Impact of an electronic sepsis initiative on antibiotic use and health care facility-onset Clostridium difficile infection rates. Am J Infect Control 2017 Oct 1; 45(10): 1091-1100.
Lelieveld C, Leipzig R, Gaber-Baylis LK, Mazumdar M, Memtsoudis SG, Zubizarreta N, Poeran J. Discharge Against Medical Advice of Elderly Inpatients in the United States. Am Geriatr Soc 2017 Sep; 65(9): 2094-2099.
Rhome RM, Moshier E, Sarpel U, Ohri N, Mazumdar M, Buckstein MH. Predictors of Positive Margins After Definitive Resection for Gastric Adenocarcinoma and Impact of Adjuvant Therapies. Int J Radiat Oncol Biol Phys 2017 Aug; 98(5): 1106-1115.
Mörwald EE, Olson A, Cozowicz C, Poeran J, Mazumdar M, Memtsoudis SG. Association of opioid prescription and perioperative complications in obstructive sleep apnea patients undergoing total joint arthroplasties. Sleep Breath 2017 Jul 24;.
Cozowicz C, Poeran J, Olson A, Mazumdar M, Mörwald EE, Memtsoudis SG. Trends in Perioperative Practice and Resource Utilization in Patients With Obstructive Sleep Apnea Undergoing Joint Arthroplasty. Anesth Analg 2017 Jul; 125(1): 66-77.
Gorbenko K, Metcalf SA, Mazumdar M, Crump C. Annual Physical Examinations and Wellness Visits: Translating Guidelines into Practice. Am J Prev Med 2017 Jun; 52(6): 813-816.
Poeran J, Gorbenko K, Babby J, Mazumdar M, Leipzig RM. Clinical decision support during electronic prescribing for elderly patients. Am J Health Syst Pharm 2017 Jun 1; 74(11): 774-776.
Kundu S, Mazumdar M, Ferket B. Impact of correlation of predictors on discrimination of risk models in development and external populations. BMC Med Res Methodol 2017 Apr 19; 17(1): 63.
Blachman NL, Leipzig RM, Mazumdar M, Poeran J. High-Risk Medications in Hospitalized Elderly Adults: Are We Making It Easy to Do the Wrong Thing?. J Am Geriatr Soc 2017 Mar; 65(3): 603-607.
Ferket BS, Feldman Z, Zhou J, Oei EH, Bierma-Zeinstra SM, Mazumdar M. Impact of total knee replacement practice: cost effectiveness analysis of data from the Osteoarthritis Initiative. BMJ 2017 Mar 28;: 356:j1131.
Cho HU, Khalil S, Poeran J, Mazumdar M, Bravo N, Wallach F, Markoff B, Lee N, Dunn AS. Lose the Tube. Am J Infect Control 2016 Dec 2; pii: S0196-6553(16): 31005-7.
Poeran J, Opperer M, Rasul R, Mazumdar M, Girardi FP, Hughes AP, Memtsoudis SG, Vougioukas V. Change in Off-Label Use of Bone Morphogenetic Protein in Spine Surgery and Associations with Adverse Outcome. Global Spine J 2016 Nov; 6(7): 650-659.
Memtsoudis SG, Poeran J, Cozowicz C, Zubizarreta N, Ozbek U, Mazumdar M. The impact of peripheral nerve blocks on perioperative outcome in hip and knee arthroplasty-a population-based study. Pain 2016 Oct; 157(10).
Galsky MD, Moshier E, Wisnivesky J, Mazumdar M. Reply to E.M. Ruggeri et al and Y.-W. Hu. J Clin Oncol 2016 Sep; 34(26).
Galsky MD, Stensland K, Sfakianos JP, Mehrazin R, Diefenbach M, Mohamed N, Tsao CK, Boffetta P, Wiklund P, Oh WK, Mazumdar M, Ferket B. Comparative Effectiveness of Treatment Strategies for Bladder Cancer With Clinical Evidence of Regional Lymph Node Involvement. J Clin Oncol 2016 Aug; 34(22): 2627-35.
Poeran J, Wasserman I, Zubizarreta N, Mazumdar M. Characteristics of Antibiotic Prophylaxis and Risk of Surgical Site Infections in Open Colectomies. Dis Colon Rectum 2016 Aug; 59(8): 733-42.
Memtsoudis SG, Poeran J, Zubizarreta N, Rasul R, Opperer M, Mazumdar M. Anesthetic Care for Orthopedic Patients: Is There a Potential for Differences in Care?. Anesthesiology 2016 Mar; 124(3): 608-23.
Galsky MD, Stensland KD, Moshier E, Sfakianos JP, McBride RB, Tsao CK, Casey M, Boffetta P, Oh WK, Mazumdar M, Wisnivesky JP. Effectiveness of Adjuvant Chemotherapy for Locally Advanced Bladder Cancer. J Clin Oncol 2016 Mar; 34(8): 825-32.
Rodrigues EG, Bellinger DC, Valeri L, Hasan MO, Quamruzzaman Q, Golam M, Kile ML, Christiani DC, Wright RO, Mazumdar M. Neurodevelopmental outcomes among 2- to 3-year-old children in Bangladesh with elevated blood lead and exposure to arsenic and manganese in drinking water. Environ Health 2016 Mar; 15(1): 44.
Poeran J, Mazumdar M, Rasul R, Meyer J, Sacks HS, Koll BS, Wallach FR, Moskowitz A, Gelijns AC. Antibiotic prophylaxis and risk of Clostridium difficile infection after coronary artery bypass graft surgery. J Thorac Cardiovasc Surg 2016 Feb; 151(2): 589-97.e2.
Cozowicz C, Poeran J, Zubizarreta N, Mazumdar M, Memtsoudis SG. Trends in the Use of Regional Anesthesia: Neuraxial and Peripheral Nerve Blocks. Reg Anesth Pain Med 2016 Jan-Feb; 41(1): 43-9.
Perkins SM, Bacchetti P, Davey CS, Lindsell CJ, Mazumdar M, Oster RA, Peduzzi PN, Rocke DM, Rudser KD, Kim M. Best Practices for Biostatistical Consultation and Collaboration in Academic Health Centers. Am Stat. 2016; 70(2): 187-194.
Ma Y, Chu H, Mazumdar M. Meta-analysis of Proportions of Rare Events: A Comparison of Exact Likelihood Methods with Robust Variance Estimation. Communication in Statistics (In Press) 2016; 45(8).
Poeran J, Babby J, Rasul R, Mazumdar M, Memtsoudis SG, Reich DL. Tales From the Wild West of US Drug Pricing: The Case of Intravenous Acetaminophen. Regional anesthesia and pain medicine 2015 May-Jun; 40(3): 284-286.
Özbek U, Poeran J, Mazumdar M, Memtsoudis SG. Patient Safety and Comparative Effectiveness of Anesthetic Technique in Open Lung Resections. Chest 2015 Mar;.
Opperer M, Poeran J, Rasul R, Mazumdar M, Memtsoudis SG. Use of perioperative hydroxyethyl starch 6% and albumin 5% in elective joint arthroplasty and association with adverse outcomes: a retrospective population based analysis. BMJ (Clinical research ed.) 2015 Mar; 350: h1567.
Poeran J, Yeo H, Rasul R, Opperer M, Memtsoudis SG, Mazumdar M. Anesthesia type and perioperative outcome: open colectomies in the United States. The Journal of surgical research 2015 Feb; 193(2): 684-692.
Elstrom RL, Ruan J, Christos PJ, Martin P, Lebovic D, Osborne J, Goldsmith S, Greenberg J, Furman RR, Avram A, Putman R, Chapman E, Mazumdar M, Griffith K, Coleman M, Leonard JP, Kaminski MS. Phase 1 study of radiosensitization using bortezomib in patients with relapsed non-Hodgkin lymphoma receiving radioimmunotherapy with 131I-tositumomab. Leukemia & lymphoma 2015 Feb; 56(2): 342-346.
Oster RA, Lindsell CJ, Welty LJ, Mazumdar M, Thurston SW, Rahbar MH, Carter RE, Pollock BH, Cucchiara AJ, Kopras EJ, Jovanovic BD, Enders FT. Assessing statistical competencies in clinical and translational science education: one size does not fit all. Clinical and translational science 2015 Feb; 8(1): 32-42.
Poeran J, Rasul R, Suzuki S, Danninger T, Mazumdar M, Opperer M, Boettner F, Memtsoudis SG. Tranexamic acid use and postoperative outcomes in patients undergoing total hip or knee arthroplasty: a study of efficacy and safety. BMJ 2014 Aug; 349: g4829.
Memtsoudis SG, Besculides MC, Mazumdar M. Rude Awakening — The Perioperative Sleep Apnea Epidemic. New England Journal of Medicine 2013 Jun; 368(25): 2352-3.
Poeran J, Mazumdar M, Memtsoudis SG. Anesthesia, Outcomes, and Public Health: Changing Health Care While “Asleep”. Reg Anesth Pain Med 2014 may-Jun; 39(3): 192-194.
Memtsoudis SG, Danninge T, Rasul R, Poeran J, Gerner P, Stundner O, Mariano ER, Mazumdar M. Inpatient falls after total knee arthroplasty: the role of anesthesia type and peripheral nerve blocks. Anesthesiology 2014 Mar; 120(3): 551-63.
Memtsoudis SG, Chiu YL, Sun X, Ramachandran SK, Kaw R, Fleischu P, Mazumdar M. The impact of sleep apnea on postoperative utilization of resources and adverse outcomes. Anesth Analg 2014 Feb; 118(2): 407-418.
Memtsoudis SG, Sun X, Chiu YL, Stundner O, Liu SS, Banerjee S, Mazumdar M, Sharrock NE. Perioperative comparative effectiveness of anesthetic technique in orthopedic patients.. Anesthesiology 2013 May; 118(5): 1046-1058.
Pumberger M, Chiu YL, Ma Y, Girardi FP, Mazumdar M, Memtsoudis SG. National in-hospital morbidity and mortality trends after lumbar fusion surgery between 1998 and 2008. J Bone Joint Surg Br 2012 Mar; 94(3): 359-64.
Ma Y, Mazumdar M, Memtsoudis SG. Beyond repeated-measures analysis of variance: advanced statistical methods for the analysis of longitudinal data in anesthesia research. Reg Anesth Pain Med 2012 Jan-Feb; 37(1): 99-105.
Ma Y, Mazumdar M. Multivariate meta-analysis: a robust approach based on the theory of the U-statistic. Stat Med 2011 Oct; 30(24): 2911-29.
Mazumdar M, Zhou KX, Tu D. Some design issues underlying strata-matched non-randomized comparative studies with survival outcome. Stat. in Med 2006; 25: 3949-3959.
Mazumdar M, Smith A, Debroy PP, Schwartz LH. A theoretical approach to choosing the minimum number of multiple tumors required for assessing treatment response. J Clin Epidemiol 2005 Feb; 58(2): 150-3.
Mazumdar M. Group sequential design for comparative diagnostic accuracy studies: Implications and guidelines for practitioners. Medical Decision Making 2004 Sep-Oct; 24(5): 525-533.
Bacik J, Mazumdar M, Murphy BA, Fairclough DA, Eremenco S, Mariani T, Motzer RJ, Cella D. The Functional Assessment of Cancer Therapy-BRM (FACT-BRM): A New Tool for the Assessment of Quality of Life in Patients Treated with Biologic Response Modifiers. Quality Life Res 2004 Feb; 13(1): 37-54.
Mazumdar M, Liu A. Group Sequential Design for comparative diagnostic accuracy studies. Stat in Med 2003 Mar; 2: 727-739.
Mazumda M, Fazzari M, Panageas KS. A standardization method to adjust for the effect of patient selection in phase II clinical trials. Stat in Med 2001 Mar; 20(6): 883-892.
Motzer RJ, Murphy BA, Bacik J, Schwartz LH, Nanus DM, Mariani T, Loehrer P, Wilding G, Fairclough DL, Cella D, Mazumdar M. Phase III trial of interferon alfa-2a with or without 13-cis-retinoic acid for patients with advanced renal cell carcinoma. J Clin Oncol 2000 Aug; 18(16): 2972-2980.
Mazumdar M, Smith A, Tong WP, Motzer RJ. Calvert’s formula for dosing carboplatin: Overview and concerns of applicability in high-dose setting. J Natl Cancer Inst 2000 Sep; 92: 1434-1436.
Mazumdar M, Glassman JR. Categorizing a prognostic variable: Review of methods, code for easy implementation and applications to decision-making about cancer treatments. Stat in Med 2000 Jan; 19: 113-132.
Begg CB, Mazumdar M. Operating characteristics of a rank correlation test for publication bias. Biometrics 1994 Dec; 50: 1088-1101.