Manav Kapoor, PhD
- ASSISTANT PROFESSOR | Neuroscience
- ASSISTANT PROFESSOR | Genetics and Genomic Sciences
Research Topics:Alzheimer's Disease, Biostatistics, Genetics, Genomics, Human Genetics and Genetic Disorders, Molecular Biology
BSc, Guru Nanak Dev University
MSc, Guru Nanak Dev University
PhD, BITS Pilani and G.N.D.U,
PostDoc, Washington University in St. Louis
Enoch-Gordis award finalist
Early Career Investigator Program (ECIP) fellowship
Fogarty ICOHRTA, International fellowship
Funded Project: ROLE OF GENOMIC IMPRINTING IN THE ETIOLOGY OF ALCOHOL DEPENDENCE
Project Narrative There is some evidence in the plant and animal literature that show that the epigenetic signatures can be passed down the generations. There is also ample evidence that show that the selective silencing of parent specific genes (genomic imprinting) can cause “hemizygous” expression of genes. In this proposal we intend to perform one of the largest meta-analysis of parent of origin analysis to identify the imprinted regions in the genome. We will further overlay the identified imprinted genomic regions on the genes showing mono-allelic mRNA expression in the RNASeq experiments on post-mortem brain samples from controls and alcohol dependent subjects. The regions with significant evidence of imprinting will be further followed in the extended high-risk addiction families using the appropriate high-throughput genomic methods to identify epigenetic signatures.
I am a human geneticist with over 10 years of research experience in genetics studies of psychiatric disorders. At Mount Sinai I am leading the genetic studies within the COGA (Collaborative Studies on Genetics of Alcoholism) Molecular Genetics laboratory. I have led several genome-wide association analyses and identified several novel genes associated with addictions including smoking and alcohol dependence. Recently, I started to collaborate with the faculty in Ronald M. Loeb Center for Alzheimer’s Disease to learn and contribute to research in the field of Alzheimer’s disease genetics.