Manoj K Jaiswal, PhD
- INSTRUCTOR | Psychiatry
Manoj Kumar Jaiswal, Ph.D. is an Instructor in the Department of Psychiatry at the Icahn School of Medicine at Mount Sinai. He obtained Ph.D. training at the Georg-August University, Goettingen, Germany. His Ph.D. worked focused on [Ca2+]i and mitochondrial signaling pathways in Amyotrophic Lateral Sclerosis (ALS). Results of these studies provided evidence of a critical role of Cu, Zn superoxide dismutase (SOD1), typical for familial ALS, in the impairment of [Ca2+]mito handling and perturbation of Ca2+ homeostasis in SOD1G93A mice and cell culture models of ALS.
He completed his Postdoctoral Fellowship at the Massachusetts Institute of Technology, McGovern Center for Brain Research in Boston, MA. He then received an NIH Career Development Award and was appointed as a Career Development Fellow and later a Senior Research Fellow at the CNRM in Bethesda, MD where he studied molecular mechanisms of Traumatic Brain Injury (TBI) using 2-photon in-vivo imaging and 3-D microscopy. At CNRM he developed a minimally invasive in-vivo 2-photon imaging method and established SCALEA2/CLARITY techniques for intact volumetric 3-D imaging of optically cleared transparent mouse brains. More recently, Dr. Jaiswal was a Research Scientist in the Department of Psychiatry at the Columbia University Medical Center in New York, where he focused on studying adult neurogenesis in the brains of patients with major depression and other psychiatric disorders.
Between 1999 and 2017 Dr. Jaiswal received numerous honors and awards, including scholarships and poster awards, and was invited to present lectures and seminars. He is a member of Society for Neuroscience (SfN) and the National Neurotrauma Society (NNS). He has been the Principal Investigator of a National Institute of Health/DoD: Pilot Project entitled: “Balance between inhibition and excitation and the vascular trauma in sensory barrel cortex after TBI: in-vivo imaging approach”. He has further contributed to the field of neuroscience as a reviewer and editor for many journals, including Scientific Reports, Annals of Neurology and Frontiers in Cellular Neuroscience. He has authored numerous articles, book and book chapters on Amyotrophic Lateral Sclerosis (ALS), Motor Neuron Disease and Psychiatric Disorders.
Throughout his career, Dr. Jaiswal has demonstrated a strong commitment to research and has shown a great deal of talent and drive. Furthermore, Dr. Jaiswal is well-respected by his colleagues and has received outstanding evaluations from his mentors and peers for his collaborative spirit as well as for his generosity in supporting and fostering learning and research of trainees and students.
Poster Award (2nd prize winner), National Capital Region TBI Research Symposium 2015. March 09-10, 2015. NIH, Bethesda, MD
Poster Award (2nd prize winner), National Capital Region TBI Research Symposium 2014. March 02-03, 2015. NIH, Bethesda, MD
Travel & Accommodation Scholarship, EMBO microscopy workshop 2009. Plymouth, UK
Travel & Accommodation Scholarship, Baltic summer school, Theor. and practical course. Aug. 17- Sep. 5, 2008. EU Marie Curie Program, Copenhagen, Denmark
Travel & Accommodation Scholarship, 4th International Summer School on Emerging Technologies in Biomedicine. June 29- July 4, 2008, Patras, Greece
Travel & Accommodation Scholarship, 4th Spring School in Regenerative medicine, Practical Course. May 18-22, 2007. Oslo, Norway
Travel & Accommodation Scholarship, FENS/IBRO PENS summer School “Imaging brain function: from molecules to mind”. September 4-24, 2006, Lausanne-Geneva, Switzerland
ADB Scholarship, Department of Biotechnology, Govt. of India
MS Scholarship, Department of Biotechnology, Govt. of India
BS Fee waiver Scholarship, Banaras Hindu University, Varanasi, India
Amyotrophic Lateral Sclerosis, Brain Imaging, Depression, Epigenetics, Gene Discovery, Gene Expressions, Gene Regulation, Gene Therapy, Image Analysis, Imaging, Knockout Mice, Mitochondria, Molecular Biology, Motor Neuron, Muscular Dystrophy, Neuro-d
More recent projects included studies related to neurodegenration in ALS, Brain Injury and psychiatric disorders. Hyperexcitability is considered to be a hallmark of ALS, and it has been suggested that the ALS-associated hyperexcitability may stem from altered function of the neuronal glutamate receptors due to inefficient RNA editing of one of the receptor’s subunits. Immediate major focus of his work will test this hypothesis using (1) autopsied tissues obtained from brain and spinal cord of ALS patients and (2) motoneurons differentiated from human induced pluripotent stem cells (hiPSC) derived from ALS patients.
Jaiswal M. Therapeutic opportunities and challenges of induced pluripotent stem cells-derived motor neurons for treatment of amyotrophic lateral sclerosis and motor neuron disease. Neural Regen Res; 12: 723-36.
Aizenstein HJ, Baskys A, Boldrini M, Butters MA, Diniz BS, Jaiswal MK, Jellinger KA, Kruglov LS, Meshandin IA, Mijajlovic MD, Niklewski G, Pospos S, Raju K, Richter K, Steffens DC, Taylor WD, Tene O. Vascular depression consensus report - a critical update. BMC medicine 2016 Nov; 14(1).
Jaiswal MK, Zech WD, Goos M, Leutbecher C, Ferri A, Zippelius A, Carrì MT, Nau R, Keller BU. Impairment of mitochondrial calcium handling in a mtSOD1 cell culture model of motoneuron disease. BMC neuroscience 2009 Jun; 10.
Jaiswal MK. Toward a High-Resolution Neuroimaging Biomarker for Mild Traumatic Brain Injury: From Bench to Bedside. Frontiers in neurology 2015; 6.
Jaiswal MK. Selective vulnerability of motoneuron and perturbed mitochondrial calcium homeostasis in amyotrophic lateral sclerosis: implications for motoneurons specific calcium dysregulation. Molecular and cellular therapies 2014; 2.
Jaiswal MK. Calcium, mitochondria, and the pathogenesis of ALS: the good, the bad, and the ugly. Frontiers in cellular neuroscience 2013; 7.
Paine A, Jaiswal MK. Promise and Pitfalls of Mitochondrial Replacement for Prevention and Cure of Heritable Neurodegenerative Diseases Caused by Deleterious Mutations in Mitochondrial DNA. Frontiers in cellular neuroscience 2016; 10.
Verma R, Xu X, Jaiswal MK, Olsen C, Mears D, Caretti G, Galdzicki Z. In vitro profiling of epigenetic modifications underlying heavy metal toxicity of tungsten-alloy and its components. Toxicology and applied pharmacology 2011 Jun; 253(3).
Jaiswal MK, Keller BU. Cu/Zn superoxide dismutase typical for familial amyotrophic lateral sclerosis increases the vulnerability of mitochondria and perturbs Ca2+ homeostasis in SOD1G93A mice. Molecular pharmacology 2009 Mar; 75(3).
Goos M, Zech WD, Jaiswal MK, Balakrishnan S, Ebert S, Mitchell T, Carrì MT, Keller BU, Nau R. Expression of a Cu,Zn superoxide dismutase typical for familial amyotrophic lateral sclerosis increases the vulnerability of neuroblastoma cells to infectious injury. BMC infectious diseases 2007 Nov; 7.
Jaiswal MK. Riluzole But Not Melatonin Ameliorates Acute Motor Neuron Degeneration and Moderately Inhibits SOD1-Mediated Excitotoxicity Induced Disrupted Mitochondrial Ca(2+) Signaling in Amyotrophic Lateral Sclerosis. Frontiers in cellular neuroscience 2016; 10.