Matthew A Levin, MD
- ASSOCIATE PROFESSOR | Anesthesiology, Perioperative & Pain Medicine
- ASSOCIATE PROFESSOR | Genetics and Genomic Sciences
Research Topics:Bioinformatics, Genomics
Dr. Levin is a Board Certified Cardiac Anesthesiologist, Board Certified Clinical Informaticist, and Director of Research Informatics for the Department of Anesthesiology, Perioperative & Pain Medicine. He holds a joint appointment in the Department of Genetics and Genomics Sciences. Matt began his career by working for five years in Silicon Valley and the software industry during the dot-com boom. He then changed careers to pursue medicine, but never lost his passion for technology. Now he is excited to be bringing the latest innovations in systems architecture, machine learning and big data into the healthcare arena, to improve patient care and save lives. He created and directs the Department of Anesthesiology's large perioperative data warehouse, which contains detailed demographic, physiologic, and medication data for over 900,000 anesthetic cases. Dr. Levin has also been leading the initiative to build a real-time, streaming data pipeline that uses machine learning to improve the early detection of unexpected clinical deterioration among hospital patients and provide real-time "early warning" alerts to clinicians.
Through his multi-disciplinary collaborations with other researchers in the Icahn School of Medicine, Dr. Levin is pushing the boundaries of perioperative research in order to answer previously un-addressable questions on the phenotype and genotype of the response to anesthetic and surgical stress. Dr. Levin is affiliated with The Charles Bronfman Institute for Personalized Medicine and collaborates closely with fellow IPM member Dr. Eimear Kenny. Together they were awarded a prestigious two year starter grant (2015-2017) from the Society of Cardiovascular Anesthesiologists to investigate the Genomics of Vasoplegia, a condition of profound, persistent hypotension sometimes seen after cardiopulmonary bypass. Dr. Levin's 2014 article "Low intraoperative tidal volume ventilation with minimal PEEP is associated with increased mortality" was recently recognized as the most cited article from 2013-2014 in the British Journal of Anaesthesia, contributing to the BJA's increase in impact factor to 5.616.
LinkedIn: https://www.linkedin.com/in/levinmd/Google Scholar:https://scholar.google.com/citations?user=cf774Sn_MysJ&hl=en ResearchGate:https://www.researchgate.net/profile/Matthew_Levin2
American Board of Anesthesiology
MD, Mount Sinai School of Medicine
BS, Massachusetts Institute of Technology
Internship, Surgery, Lenox Hill Hospital
Residency, Anesthesiology, Mount Sinai Hospital
Fellowship, Cardiothoracic Anes., Mount Sinai Hospital
Starter Grant - Genomics of Vasoplegia
Dr. Levin is investigating the genomic basis of vasoplegia - a state of profound, refractory hypotension often seen in patients undergoing cardiac surgery.
Levin MA, Joseph TT, Jeff JM, Nadukuru R, Ellis SB, Bottinger EP, Kenny EE. iGAS: A framework for using electronic intraoperative medical records for genomic discovery. Journal of biomedical informatics 2017 Mar; 67.
Levin MA, McCormick PJ, Lin HM, Hosseinian L, Fischer GW. Low intraoperative tidal volume ventilation with minimal PEEP is associated with increased mortality. British journal of anaesthesia 2014 Jul; 113(1).
Mandel-Portnoy Y, Levin MA, Bansilal S, Suprun M, Lin HM, Richardson LD, Fischer GW, Halperin JL. Low intraoperative heart rate volatility is associated with early postoperative mortality in general surgical patients: a retrospective case-control study. Journal of clinical monitoring and computing 2015 Oct;.
Levin MA, Fischer GW, Lin HM, McCormick PJ, Krol M, Reich DL. Intraoperative arterial blood pressure lability is associated with improved 30 day survival. British journal of anaesthesia 2015 Nov; 115(5).
Levin MA, Krol M, Doshi AM, Reich DL. Extraction and mapping of drug names from free text to a standardized nomenclature. AMIA ... Annual Symposium proceedings / AMIA Symposium. AMIA Symposium 2007;.
Levin MA, Lin HM, Castillo JG, Adams DH, Reich DL, Fischer GW. Early on-cardiopulmonary bypass hypotension and other factors associated with vasoplegic syndrome. Circulation 2009 Oct; 120(17).
Fischer GW, Levin MA. Vasoplegia during cardiac surgery: current concepts and management. Seminars in thoracic and cardiovascular surgery 2010; 22(2).
Phillips AT, Deiner S, Mo Lin H, Andreopoulos E, Silverstein J, Levin MA. Propofol Use in the Elderly Population: Prevalence of Overdose and Association With 30-Day Mortality. Clinical therapeutics 2015 Dec; 37(12).
Levin MA, Wanderer JP, Ehrenfeld JM. Data, Big Data, and Metadata in Anesthesiology. Anesthesia and analgesia 2015 Dec; 121(6).
Hosseinian L, Weiner M, Levin MA, Fischer GW. Methylene Blue: Magic Bullet for Vasoplegia?. Anesthesia and analgesia 2016 Jan; 122(1).
Hosseinian L, Levin MA, Fischer GW, Anyanwu AC, Torregrossa G, Evans AS. Hemodynamic deterioration during extracorporeal membrane oxygenation weaning in a patient with a total artificial heart. Critical care medicine 2015 Jan; 43(1).
Levin MA, Anyanwu AC, Eggert CA, Mittnacht AJ. Use of an automatic internal defibrillator to induce and maintain ventricular fibrillation during left ventricular assist device pump exchange. The Journal of thoracic and cardiovascular surgery 2014 Mar; 147(3).