Michael Rendl, MD
- ASSOCIATE PROFESSOR | Cell, Developmental & Regenerative Biology
- ASSOCIATE PROFESSOR | Dermatology
Research Topics:Developmental Biology, Morphogenesis, Regeneration, Stem Cells
Michael Rendl is a stem cell biologist studying the function of stem cell niches. A major focus of his work is to uncover how specialized Dermal Papilla cells act as instructive niche for hair follicle stem cells during embryonic hair follicle formation and adult hair growth and regeneration.
For more detailed information, please visit the Rendl Lab website.
Multi-Disciplinary Training AreaDevelopment, Regeneration, and Stem Cells [DRS]
MD, Medical University of Vienna
Postdoctoral Fellowship, Rockefeller University
Irma T. Hirschl Trust Research Award
Research Career Development Award Dermatology Foundation
Schrodinger Fellow of the Austrian Science Fund
Max Kade Fellow of the Austrian Academy of Sciences
AESCA Award for Dermatological Research
The Rendl Laboratory studies the formation and function of stem cell niches. Specifically, we utilize genetic mouse models for embryonic hair follicle formation and for adult hair growth and regeneration to uncover how specialized Dermal Papilla (DP) cells act as instructive niche cells for hair follicle stem cells. A major focus is also to define how DP cells acquire the hair-inducing cell fate in the first place that sets them apart from regular skin fibroblasts. Insights from these studies will reveal general mechanisms on how stem cell niches function and provide a platform for developing hair regenerative therapies. For more detailed information, please visit the Rendl Lab website.
Rezza A, Wang Z, Sennett R, Qiao W, Wang D, Heitman N, Mok KW, Clavel C, Yi R, Zandstra P, Ma'ayan A, Rendl M. Signaling Networks among Stem Cell Precursors, Transit-Amplifying Progenitors, and their Niche in Developing Hair Follicles. Cell reports 2016 Mar;.
Sennett R, Wang Z, Rezza A, Grisanti L, Roitershtein N, Sicchio C, Mok KW, Heitman NJ, Clavel C, Ma'ayan A, Rendl M. An Integrated Transcriptome Atlas of Embryonic Hair Follicle Progenitors, Their Niche, and the Developing Skin. Developmental cell 2015 Aug;.
Sennett R, Rendl M. Developmental biology. A scar is born: origins of fibrotic skin tissue. Science (New York, N.Y.) 2015 Apr; 348(6232).
Rezza A, Sennett R, Tanguy M, Clavel C, Rendl M. PDGF signalling in the dermis and in dermal condensates is dispensable for hair follicle induction and formation. Experimental dermatology 2015 Feb;.
Siegle JM, Basin A, Sastre-Perona A, Yonekubo Y, Brown J, Sennett R, Rendl M, Tsirigos A, Carucci JA, Schober M. SOX2 is a cancer-specific regulator of tumour initiating potential in cutaneous squamous cell carcinoma. Nature communications 2014 Jul; 5.
Sennett R, Rezza A, Dauber KL, Clavel C, Rendl M. Cxcr4 is transiently expressed in both epithelial and mesenchymal compartments of nascent hair follicles but is not required for follicle formation. Experimental dermatology 2014 Jul;.
Rezza A, Sennett R, Rendl M. Adult stem cell niches: cellular and molecular components. Current topics in developmental biology 2014; 107: 333-72.
Tsai SY, Sennett R, Rezza A, Clavel C, Grisanti L, Zemla R, Najam S, Rendl M. Wnt/β-catenin signaling in dermal condensates is required for hair follicle formation. Developmental biology 2014 Jan; 385(2): 179-88.
Grisanti L, Rezza A, Clavel C, Sennett R, Rendl M. Enpp2/Autotaxin in dermal papilla precursors is dispensable for hair follicle morphogenesis. The Journal of investigative dermatology 2013 Oct; 133(10): 2332-9.
Grisanti L, Clavel C, Cai X, Rezza A, Tsai SY, Sennett R, Mumau M, Cai CL, Rendl M. Tbx18 targets dermal condensates for labeling, isolation, and gene ablation during embryonic hair follicle formation. The Journal of investigative dermatology 2013 Feb; 133(2): 344-53.
Clavel C, Grisanti L, Zemla R, Rezza A, Barros R, Sennett R, Mazloom AR, Chung CY, Cai X, Cai CL, Pevny L, Nicolis S, Ma'ayan A, Rendl M. Sox2 in the dermal papilla niche controls hair growth by fine-tuning BMP signaling in differentiating hair shaft progenitors. Developmental cell 2012 Nov; 23(5): 981-94.
Sennett R, Rendl M. Mesenchymal-epithelial interactions during hair follicle morphogenesis and cycling [review]. Seminars in cell & developmental biology 2012 Oct; 23(8): 917-27.
Tsai SY, Bouwman BA, Ang YS, Kim SJ, Lee DF, Lemischka IR, Rendl M. Single transcription factor reprogramming of hair follicle dermal papilla cells to induced pluripotent stem cells. Stem Cells 2011 Jun; 29(6): 964-71.
Ang YS, Tsai SY, Lee DF, Monk J, Su J, Ratnakumar K, Ding J, Ge Y, Darr H, Chang B, Wang J, Rendl M, Bernstein E, Schaniel C, Lemischka IR. Wdr5 mediates self-renewal and reprogramming via the embryonic stem cell core transcriptional network. Cell 2011 Apr; 145(2): 183-97.
Driskell RR, Clavel C, Rendl M, Watt FM. Hair follicle dermal papilla cells at a glance. Journal of Cell Science 2011 Apr; 124(Pt 8): 1179-82.
Tsai SY, Clavel C, Kim S, Ang YS, Grisanti L, Lee DF, Kelley K, Rendl M. Oct4 and klf4 reprogram dermal papilla cells into induced pluripotent stem cells. Stem Cells 2010 Feb; 28(2): 221-8.
Nguyen H, Merrill BJ, Polak L, Nikolova M, Rendl M, Shaver TM, Pasolli HA, Fuchs E. Tcf3 and Tcf4 are essential for long-term homeostasis of skin epithelia. Nature Genetics 2009 Oct; 41(10): 1068-75.
Greco V, Chen T, Rendl M, Schober M, Pasolli HA, Stokes N, Dela Cruz-Racelis J, Fuchs E. A two-step mechanism for stem cell activation during hair regeneration. Cell Stem Cell 2009 Feb; 4(2): 155-69.
Rendl M, Polak L, Fuchs E, Schober M, Pasolli HA, Stokes N, Dela Cruz-Racelis J, Fuchs E. BMP signaling in dermal papilla cells is required for their hair follicle-inductive properties. Genes & Development 2008 Feb; 22(4): 543-57.
Nguyen H, Rendl M, Fuchs E. Tcf3 governs stem cell features and represses cell fate determination in skin. Cell 2006 Oct; 127(1): 171-83.
Rendl M, Lewis L, Fuchs E. Molecular dissection of mesenchymal-epithelial interactions in the hair follicle. PLoS Biology 2005 Nov; 3(11).
Tumbar T, Guasch G, Greco V, Blanpain C, Lowry WE, Rendl M, Fuchs E. Defining the epithelial stem cell niche in skin. Science 2004 Jan; 303(5656): 359-63.