Michael S Breen, PhD
- ASSISTANT PROFESSOR | Genetics and Genomic Sciences
Research Topics:Autism, Computational Biology, Developmental Biology, Gene Discovery, Gene Regulation, Gene editing, Genetics, Genomics, Immunology, Inflammation, Neurobiology, Proteomics, Psychiatry, RNA, Schizophrenia, Systems Biology
Research in our laboratory aims to better understand the molecular factors underlying neurodevelopmental and neuropsychiatric disorders. We are specifically focused on two mechanistic-domains: 1) A-to-I RNA editing in the brain; and 2) immune mechanisms in the blood - both of which hold great promise for the development of actionable biomarkers and next generation theraputics. Our research studies generate functional genomic data sets (e.g. scRNA-seq, proteomics, metabolimics) from patient-derived tissues (e.g. peripheral blood, cord blood, postmortem brain tissue, iPSCs) using molecular biology and immunology tools, and subsequently analyze these data under a prism of computational and biostatistical methods. In doing so, we strive to construct biologically plausible mechanistic models of disease, for which we validate both functionally and clinically.
PhD, University of Southampton
Postdoctoral Research Fellow, Ichan School of Medicine at Mount Sinai