
Mone Zaidi, MD, PhD
- PROFESSOR | Medicine, Endocrinology, Diabetes and Bone Disease
- PROFESSOR | Pharmacological Sciences
- PROFESSOR | Geriatrics and Palliative Medicine
Specialty:
Endocrine, Diabetes and Bone Diseases (Endocrinology)Research Topics:
Bone Biology, Bone Metabolism, Genetics, Hormones, Neuro-degeneration/protection, Obesity, Osteoporosis, Skeletal BiologyMone Zaidi graduated in medicine from King George’s Medical College, India, and trained clinically at the Hammersmith Hospital, London, under the tutelage of Professor Iain MacIntyre, FRS, who discovered calcitonin. After obtaining a PhD and MD from the University of London, Dr. Zaidi held faculty appointments for over 8 years, before he was recruited to Mount Sinai School of Medicine as Professor of Medicine and Founding Director of The Mount Sinai Bone Program. He is now Director of Mount Sinai’s Center for Translational Medicine and Pharmacology and was recently appointed as Deputy Editor for eLife where he is responsible for the medicine section of the journal.
Dr. Zaidi has made groundbreaking discoveries on mechanisms of skeletal homeostasis in health and disease. These studies, spanning over 30 years, included the first description of calcium sensing in the osteoclast and the discovery that locally released nitric oxide acts to suppress bone cells. In 2003, Zaidi’s group published the first evidence for a pituitary–bone axis, a breakthrough in physiology in which pituitary hormones could affect the skeleton directly. In recent groundbreaking papers in Nature, he found that inhibiting FSH not only increased bone mass, but also reduced body fat and neurodegeneration--in essence, laying a firm foundation for a single anti-FSH agent to treat osteoporosis, obesity and Alzheimer’s disease.
The corpus of work relating FSH to body fat was selected by Nature Medicine as one of eight “Notable Advances” in biomedicine for 2017 and was editorialized in the New York Times. Constituting a total of over 450 publications in journals, including Cell, Nature and PNAS, Zaidi’s research has been funded continuously by the NIH. He has also Chaired multiple Study Sections for the NIH and the Department of Veterans Affairs He was elected to the Association of American Physicians, Interurban Clinical Club of which he is President, the Practitioners’ Society (the oldest medical society in the U.S.) and the Association of Professors of Medicine. Dr. Zaidi was made Master of the American College of Physicians, received the Harrington Scholar–Innovator Award, was elected as Fellow of the American Association of Advancement of Science, and is recipient of three honorary doctorates.
Clinical Focus
- Hyperparathyroidism
- Osteoporosis
- Paget's Disease of Bone
- Vitamin D Deficiency
Multi-Disciplinary Training Area
Development Regeneration and Stem Cells [DRS]Education
PhD, Royal Postgraduate Medical School
MBBS, King George's Medical College
MD, University of London
Residency, Medicine/Endoc., Royal Postgraduate Medical School
-
2020
Deputy Editor for Medicine -
2019
Fellow -
2019
The J. Lester Gabrilove Award -
2019
Fellow -
2018
Foreign Fellow -
2018
Honorary Member -
2018
Harrison Society Visiting Professor -
2017
Doctorate of Science Honoris Causa -
2017
Mastership in the American College of Physicians (MACP) -
2017
Harrington Scholar- Innovator Award -
2016
The Practitioners Society -
2016
President -
2016
Faculty Council Award for Academic Excellence -
2014
Honorary Member -
2014
Association of Professors of Medicine (by nomination) -
2013
Doctor of Science Honoris Causa -
2010
Honorary Doctor of Medicine (Laurea Honoris Causa), -
2010
Sreebny Distinguished Lecture, -
2009
The Marookian Lecture -
2008
Kramer Visiting Professor -
2008
Sibte H. Zaidi Memorial Oration -
2006
Highlight Speaker -
2005
Scientific Director and Chair -
2005
Invited Speaker -
2004
Member -
2002
Eweson Lecturer -
2001
National Scientific Advisory Council & Research Committee -
2000
Advisory Group Member -
2000
Foster Lecture -
2000
Member -
1998
Fellow -
1995
Fellow -
1995
Fellow -
1988
Lecturer -
1983
Award -
Member -
Research Excellence Award - Department of Veterans Affairs -
Committee Member -
Fellow -
Award
Dr. Zaidi has made groundbreaking discoveries on mechanisms of skeletal homeostasis in health and disease. These studies, spanning over 30 years, included the first description of calcium sensing in the osteoclast and the discovery that locally released nitric oxide acts to suppress bone cells. In 2003, Zaidi’s group published the first evidence for a pituitary–bone axis, a breakthrough in physiology in which pituitary hormones could affect the skeleton directly. In recent groundbreaking papers in Nature, he found that inhibiting FSH not only increased bone mass, but also reduced body fat and neurodegeneration--in essence, laying a firm foundation for a single anti-FSH agent to treat osteoporosis, obesity and Alzheimer’s disease.
Physicians and scientists on the faculty of the Icahn School of Medicine at Mount Sinai often interact with pharmaceutical, device and biotechnology companies to improve patient care, develop new therapies and achieve scientific breakthroughs. In order to promote an ethical and transparent environment for conducting research, providing clinical care and teaching, Mount Sinai requires that salaried faculty inform the School of their relationships with such companies.
Below are financial relationships with industry reported by Dr. Zaidi during 2021 and/or 2022. Please note that this information may differ from information posted on corporate sites due to timing or classification differences.
Consulting:
- AvoPro; Avoro Capital advisors; Bowman and Brooke; Gerson Lehrman Group; Guidepoint Global, LLC.
Equity (Stock or stock options valued at greater than 5% ownership of a publicly traded company or equity of any value in a privately held company)
- Mone Zaidi Consulting Inc.
Other Activities: Examples include, but are not limited to, committee participation, data safety monitoring board (DSMB) membership.
- Elsevier; National Institutes of Health (NIH); New York Academy of Sciences; Shengyang Hospital; eLife
Mount Sinai's faculty policies relating to faculty collaboration with industry are posted on our website. Patients may wish to ask their physician about the activities they perform for companies.
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