Mone Zaidi, MD, PhD
- PROFESSOR | Medicine, Endocrinology, Diabetes and Bone Disease
- PROFESSOR | Pharmacological Sciences
- PROFESSOR | Geriatrics and Palliative Medicine
Specialty:
Endocrine, Diabetes and Bone DiseasesResearch Topics:
Bone Biology, Bone Metabolism, Cell Biology, Cytokines, Developmental Biology, Gene Expressions, Genetics, Hormones, Immunosuppression, Macrophage, Microarray, Molecular Biology, Neuromodulation, Osteoporosis, Signal Transduction, Skeletal Biology, Thyroid, Transcription FactorsClinical Focus
- Hyperparathyroidism
- Osteoporosis
- Paget's Disease of Bone
- Vitamin D Deficiency
Multi-Disciplinary Training Area
Development, Regeneration, and Stem Cells [DRS]Education
PHD, Royal Postgraduate Medical School
MBBS, King George's Medical College
MD, University of London
Residency, Medicine-Endoc, Royal Postgraduate Medical School
-
2010
Honorary Doctor of Medicine (Laurea Honoris Causa), -
2010
Sreebny Distinguished Lecture, -
2009
The Marookian Lecture -
2008
Kramer Visiting Professor -
2008
Sibte H. Zaidi Memorial Oration -
2006
Hightlight Speaker -
2005
Scientific Director and Chair -
2005
Invited Speaker -
2004
Elected -
2002
Eweson Lecturer -
2001
National Scientific Advisory Council & Research Committee -
2000
Elected -
2000
Elected -
2000
Foster Lecture -
2000
Member -
1998
Fellow -
1995
Fellow -
1995
Award -
1988
Lecturer -
1983
Award -
Member -
Research Excellence Award - Department of Veterans Affairs -
Elected -
Fellow -
Award
Research
Mone Zaidi has made seminal contributions to the pathogenesis and therapy of osteoporosis, a devastating public health hazard. These include the first description of extracellular calcium sensing by the osteoclast; evidence that nuclear calcium in bone cells is tightly regulated by ryanodine receptors; and the discovery that nitric oxide controls osteoclast function. More recently, he established the concept of a pituitary-bone axis, in which the pituitary hormones FSH, TSH, ACTH and oxytocin directly regulate the skeleton. The idea that low TSH contributes to the osteoporosis of thyroid disorders has led to revised criteria that mandate less aggressive TSH suppression. Similarly, the rapid late peri-menopausal bone loss, which is now partly attributable to a rising FSH, has prompted new guidelines for early evaluation of women. The finding that ACTH attenuates avascular necrosis of the hip will likewise help prevent this crippling complication of long-term steroid use. Finally, Dr. Zaidi has proven that the inhibition of calcineurin in the osteoblast by the widely used immunosuppressant drugs cyclosporine and tacrolimus underlies the acute, rapid, and severe bone loss in transplant patients. These observations have thus created new paradigms for understanding and treating osteoporosis. Importantly, Dr. Zaidi has chaired several standing study sections, and has conceptualized and runs one of the most revered international conferences in skeletal biology and medicine.
Physicians and scientists on the faculty of the Icahn School of Medicine at Mount Sinai often interact with pharmaceutical, device and biotechnology companies to improve patient care, develop new therapies and achieve scientific breakthroughs. In order to promote an ethical and transparent environment for conducting research, providing clinical care and teaching, Mount Sinai requires that salaried faculty inform the School of their relationships with such companies.
Below are financial relationships with industry reported by Dr. Zaidi during 2018 and/or 2019. Please note that this information may differ from information posted on corporate sites due to timing or classification differences.
Consulting:
- F. Hoffman-La Roche Ltd.; Genzyme Corporation; Gerson Lehrman Group; Merck & Co., Inc.
Industry-Sponsored Lectures: MSSM faculty occasionally give lectures at events sponsored by industry, but only if the events are free of any marketing purpose.
- Takeda Pharmaceuticals International GmbH
Mount Sinai's faculty policies relating to faculty collaboration with industry are posted on our website. Patients may wish to ask their physician about the activities they perform for companies.
Physicians who provide services at hospitals and facilities in the Mount Sinai Health System might not participate in the same health plans as those Mount Sinai hospitals and facilities (even if the physicians are employed or contracted by those hospitals or facilities).
Information regarding insurance participation and billing by this physician may be found on this page, and can also be obtained by contacting this provider directly. Because physicians insurance participation can change, the insurance information on this page may not always be up-to-date. Please contact this physician directly to obtain the most up-to-date insurance information.
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