Mone Zaidi, MD, PhD

• 2010
  Honorary Doctor of Medicine (Laurea Honoris Causa),
  

• 2010
  Sreebny Distinguished Lecture,
  

• 2009
  The Marookian Lecture
  

• 2008
  Kramer Visiting Professor
  

• 2008
  Sibte H. Zaidi Memorial Oration
  

• 2006
  Hightlight Speaker
  

• 2005
  Scientific Director and Chair
  

• 2005
  Invited Speaker
  

• 2004
  Elected
  

• 2002
  Eweson Lecturer
  

• 2001
  National Scientific Advisory Council & Research Committee
  

• 2000
  Elected
  

• 2000
  Elected
  

• 2000
  Foster Lecture
  

• 2000
  Member
  

• 1998
  Fellow
  

• 1995
  Fellow
  

• 1995
  Award
  

• 1988
  Lecturer
  

• 1983
  Award
  

• 
  Member
  

• 
  Research Excellence Award - Department of Veterans Affairs
  

• 
  Elected
  

• 
  Fellow
  

• 
  Award
  

Research

Mone Zaidi has made seminal contributions to the pathogenesis and therapy of osteoporosis, a devastating public health hazard.  These include the first description of extracellular calcium sensing by the osteoclast; evidence that nuclear calcium in bone cells is tightly regulated by ryanodine receptors; and the discovery that nitric oxide controls osteoclast function.  More recently, he established the concept of a pituitary-bone axis, in which the pituitary hormones FSH, TSH, ACTH and oxytocin directly regulate the skeleton.  The idea that low TSH contributes to the osteoporosis of thyroid disorders has led to revised criteria that mandate less aggressive TSH suppression.  Similarly, the rapid late peri-menopausal bone loss, which is now partly attributable to a rising FSH, has prompted new guidelines for early evaluation of women.  The finding that ACTH attenuates avascular necrosis of the hip will likewise help prevent this crippling complication of long-term steroid use.  Finally, Dr. Zaidi has proven that the inhibition of calcineurin in the osteoblast by the widely used immunosuppressant drugs cyclosporine and tacrolimus underlies the acute, rapid, and severe bone loss in transplant patients.  These observations have thus created new paradigms for understanding and treating osteoporosis.  Importantly, Dr. Zaidi has chaired several standing study sections, and has conceptualized and runs one of the most revered international conferences in skeletal biology and medicine.

Zaidi M, Sun L, Robinson LJ, Tourkova IL, Liu L, Wang Y, Zhu LL, Liu X, Liu JH, Peng YZ, Yang G, Sun H, Levine A, Iqbal J, Yaroslavskiy BB, Isales C, Blair HC, . ACTH protects against glucocorticoid-induced osteonecrosis of bone. Proceedings of the National Academy of Science 2010;(107): 8782-8787.

Iqbal J, Sun L, Zaidi M. Coupling bone degradation and formation.. Nature Medicine 2009;(15): 729-731.

Tamma R, Colaianni G, Zhu LL, DiBenedetto A, Greco G, Montemurro G, Patano N, Strippoli M, Vergari R, Mancini L, Colucci S, Grano MM, Faccio R, Liu X, Li J, Usmani S, Nishimori K, Young L, Bachar M, Bab I, Buettner C, Iqbal J, Sun L, Zaidi M, Zallone A. Oxytocin is an anabolic bone hormone.. Proceeding of the national Academy of Science 2008;(106): 7149-7154.

Sun L, Vukicevic S, Baliram A, Yang G, Sendak R, McPherson J, Zhu LL, Iqbal J, Latif R, Natrajan A, Arabi A, Yamoah KO, Moonga BS, Gabet Y, Davies TF, Bab I, Abe E, Sampath K, Zaidi M, , . Intermittent recombinant TSH injection prevents ovariectomy-induced bone loss.. Proceedings of the national Academy of Sciences 2008;(105): 4289-4294.

Zaidi M. Skeletal remodeling in health and disease. Nature Medicine 2007;(13): 791-801.

Iqbal J, Sun L, Kumar TR, Blair HC, Zaidi M. FSH stimulates TNF production from immune cells to trigger osteoclast and osteoblast formation.. Proceedings of the National Academy of Sciences;(103): 14925-14930.

Hase H, Ando T, Eldeiry L, Brebene A, Peng Y, Lin L, Amano H, Davies TF, Sun L, Zaidi M, Abe E. TNF mediates the skeletal effects of TSH. Proceedings of the National Academy of Sciences;(103): 12849-12854.

Sun L, Zhang Z, Iqbal J, Zaidi S, Papachristou DJ, Zhou H, Sharrow AC, Peng Y, Yaroslavskiy BB, Zhu LL, Zallone A, Sairam MR, Kumar TR, Landa LC, Schaffler MB, Moonga BS, Blair HC, Zaidi M. FSH directly regulates bone mass.. Cell 2006;(125): 247-260.

Sun L, Blair HC, Peng Y, Zaidi N, Adebanjo OA, Wu XB, Wu XY, Iqbal J, Epstein S, Abe E, Moonga BS, Zaidi M. Calcineurin regulates bone formation by the osteoblast.. Proceedings of the National Academy of Sciences 2005;(47): 17130-17135.

Abe E, Marians R, Wu XB, Iqbal J, Ando T, Blair HC, Davies TF, Zaidi M. TSH is a negative regulator of bone remodelling.. Cell;(175): 151-162.