Mone Zaidi - Endocrine, Diabetes and Bone Diseases (Endocrinology)

Biography

Specialties

Endocrine, Diabetes and Bone Diseases (Endocrinology)

Research Topics

Bone Biology, Bone Metabolism, Genetics, Hormones, Neuro-degeneration/protection, Obesity, Osteoporosis, Skeletal Biology

Multi-Disciplinary Training Area

Genetics and Genomic Sciences [GGS]

Research

Dr. Zaidi has made groundbreaking discoveries on mechanisms of skeletal homeostasis in health and disease. These studies, spanning over 30 years, included the first description of calcium sensing in the osteoclast and the discovery that locally released nitric oxide acts to suppress bone cells. In 2003, Zaidi’s group published the first evidence for a pituitary–bone axis, a breakthrough in physiology in which pituitary hormones could affect the skeleton directly. In recent groundbreaking papers in Nature, he found that inhibiting FSH not only increased bone mass, but also reduced body fat and neurodegeneration--in essence, laying a firm foundation for a single anti-FSH agent to treat osteoporosis, obesity and Alzheimer’s disease.

Education

MBBS, King Georges Medical University

MD, University of London

Residency, Endocrinology, Diabetes and Metabolism, Hammersmith Hospital

Honors & Awards

2020

Deputy Editor for Medicine

eLife Journal

2019

Fellow

American Society for Bone and Mineral Research (Class of 2019)

2019

The J. Lester Gabrilove Award

Mount Sinai Alumnus Association

2019

Fellow

American Association for the Advancement of Science

2018

Foreign Fellow

National Academy of Sciences of India

2018

Honorary Member

Tinsley Randolph Harrison Society, Vanderbilt

2018

Harrison Society Visiting Professor

Vanderbilt University

2017

Doctorate of Science Honoris Causa

Amity University, India

2017

Mastership in the American College of Physicians (MACP)

American College of Physicians (MACP)

2017

Harrington Scholar- Innovator Award

Harrington Discovery Institute

2016

The Practitioners Society

New York (by invitation, est. 1882)

2016

President

Interurban Clinical Club

2016

Faculty Council Award for Academic Excellence

Mount Sinai

2014

Honorary Member

International Chinese Musculoskeletal Research Society

2014

Association of Professors of Medicine (by nomination)

2013

Doctor of Science Honoris Causa

Postgraduate Institute of Medical Sciences, India

2010

Honorary Doctor of Medicine (Laurea Honoris Causa),

University of Bari

2010

Sreebny Distinguished Lecture,

State University of New York, Stony Brook,

2009

The Marookian Lecture

University of Pennsylvania

2008

Kramer Visiting Professor

Dartmouth Medical School

2008

Sibte H. Zaidi Memorial Oration

Indian Institute of Toxicology Research, India

2006

Highlight Speaker

NIA Council

2005

Scientific Director and Chair

New York Skeletal Biology and Medicine Conferences Highlight Speaker, NIA Council

2005

Invited Speaker

Japanese Bone and Mineral society

2004

Member

Association of American Physicians

2002

Eweson Lecturer

Cambridge Philosophical Society

2001

National Scientific Advisory Council & Research Committee

American Federation for Aging Research

2000

Advisory Group Member

Department of Veterans Affairs Medical Research Advisory Group

2000

Foster Lecture

University of Cambridge

2000

Member

American Society for Clinical Investigation

1998

Fellow

Royal College of Pathologists

1995

Fellow

Tata Memorial Scholar, London

1995

Fellow

Institute of Biologists of England

1988

Lecturer

Nuffield Award for Science Lecturer, London

1983

Award

Stott Gold Medal in Pathology

Fellow

Royal College of Physicians

Award

Sir Edmund Davis Scholarship

Member

Association of Osteobiology, Interurban Clinical Club, Councilor

Research Excellence Award - Department of Veterans Affairs

NIH Orthopedics and Musculoskeletal Study Section

Committee Member

Department of Veterans Affairs Endocrine Merit Review Committee

Publications

368

Publications

Selected Publications

FSH and ApoE4 contribute to Alzheimer’s disease-like pathogenesis via C/EBPβ/δ-secretase in female mice. Jing Xiong, Seong Su Kang, Mengmeng Wang, Zhihao Wang, Yiyuan Xia, Jianming Liao, Xia Liu, Shan Ping Yu, Zhaohui Zhang, Vitaly Ryu, Tony Yuen, Mone Zaidi, Keqiang Ye. Nature Communications

Pituitary crosstalk with bone, adipose tissue and brain. Mone Zaidi, Tony Yuen, Se Min Kim. Nature Reviews Endocrinology

Absent LH signaling rescues the anxiety phenotype in aging female mice. Steven Sims, Orly Barak, Vitaly Ryu, Sari Miyashita, Hasni Kannangara, Funda Korkmaz, Soleil Wizman, Anne Macdonald, Anisa Gumerova, Ki Goosens, Mone Zaidi, Tony Yuen, Daria Lizneva, Tal Frolinger. Molecular Psychiatry

View All Publications

Office Locations

Atran Berg Laboratory Building Floor 4th floor Room AB4-06

1428 Madison Ave

New York, NY 10029

212-241-8797

Industry Relationships

Physicians and scientists on the faculty of the Icahn School of Medicine at Mount Sinai often interact with pharmaceutical, device, biotechnology companies, and other outside entities to improve patient care, develop new therapies and achieve scientific breakthroughs. In order to promote an ethical and transparent environment for conducting research, providing clinical care and teaching, Mount Sinai requires that salaried faculty inform the School of their outside financial relationships.

Below are financial relationships with industry reported by Dr. Zaidi during 2023 and/or 2024. Please note that this information may differ from information posted on corporate sites due to timing or classification differences.

Consulting or Other Professional Services Examples include, but are not limited to, committee participation, data safety monitoring board (DSMB) membership

Gerson Lehrman Group
Rani Pharmaceuticals
Guidepoint Global, LLC.
Bowman and Brooke

Editorial Services

eLife
National Institutes of Health (NIH)

Mount Sinai's faculty policies relating to faculty collaboration with industry are posted on our website. Patients may wish to ask their physician about the activities they perform for companies.

Physicians and scientists on the faculty of the Icahn School of Medicine at Mount Sinai often interact with pharmaceutical, device, biotechnology companies, and other outside entities to improve patient care, develop new therapies and achieve scientific breakthroughs. In order to promote an ethical and transparent environment for conducting research, providing clinical care and teaching, Mount Sinai requires that salaried faculty inform the School of their outside financial relationships.

Below are financial relationships with industry reported by Dr. Zaidi during 2023 and/or 2024. Please note that this information may differ from information posted on corporate sites due to timing or classification differences.

Consulting or Other Professional Services Examples include, but are not limited to, committee participation, data safety monitoring board (DSMB) membership

Gerson Lehrman Group
Rani Pharmaceuticals
Guidepoint Global, LLC.
Bowman and Brooke

Editorial Services

eLife
National Institutes of Health (NIH)

Mount Sinai's faculty policies relating to faculty collaboration with industry are posted on our website. Patients may wish to ask their physician about the activities they perform for companies.