Panagiotis Roussos, MD, PhD
- ASSOCIATE PROFESSOR | Genetics and Genomic Sciences
- ASSOCIATE PROFESSOR | Psychiatry
Research Topics:Alzheimer's Disease, Bioinformatics, Brain, Cerebral Cortex, Chromatin, Computational Biology, Epigenetics, Gene Expressions, Gene Regulation, Genetics, Genomics, Microarray, Neurobiology, Neuroscience, Prefrontal Cortex, Schizophrenia, Systems Biology
Panos Roussos is an Associate Professor of Psychiatry and Genetics and Genomic Sciences at the Icahn School of Medicine at Mount Sinai. He is a member of Icahn Institute - Genomics and Multiscale Biology and Friedman Brain Institute. He is also a VA/MIRECC Research Physician at the James J. Peters VA Medical Center.
Panos Roussos received his medical and doctorate degrees from the University of Crete in Greece. He completed his residency in Psychiatry (research track) at Icahn School of Medicine at Mount Sinai followed by a MIRECC research fellowship in schizophrenia.
Multi-Disciplinary Training AreasGenetics and Genomic Sciences [GGS], Neuroscience [NEU]
MD, University of Crete Medical School
MD, University of Crete
MS, University of Crete
PhD, University of Crete
Residency, Icahn School of Medicine at Mount Sinai
Residency, Psychiatry, Mount Sinai School of Medicine
Fellowship, Schizophrenia, Mount Sinai School of Medicine
Young Investor Award
Early Academic Career Award
Outstanding Resident Award
Panos Roussos's research is focused on discerning the neurobiology of neuropsychiatric illnesses through understanding the regulation of gene expression. He applies a combination of Molecular Biology and Bioinformatics approaches to tackle these questions.
Visit our website: http://labs.icahn.mssm.edu/functionalneurogenomics-lab/
Roussos P, Giakoumaki SG, Bitsios P. Tolcapone effects on gating, working memory, and mood interact with the synonymous catechol-O-methyltransferase rs4818c/g polymorphism. Biological psychiatry 2009 Dec; 66(11).
Roussos P, Katsel P, Davis KL, Bitsios P, Giakoumaki SG, Jogia J, Rozsnyai K, Collier D, Frangou S, Siever LJ, Haroutunian V. Molecular and genetic evidence for abnormalities in the nodes of Ranvier in schizophrenia. Archives of general psychiatry 2012 Jan; 69(1).
Roussos P, Katsel P, Davis KL, Siever LJ, Haroutunian V. A system-level transcriptomic analysis of schizophrenia using postmortem brain tissue samples. Archives of general psychiatry 2012 Dec; 69(12).
Roussos P. Transcription factor 4 as an important determinant of gating function in schizophrenia. Proceedings of the National Academy of Sciences of the United States of America 2012 Apr; 109(16).
Roussos P, Katsel P, Davis KL, Giakoumaki SG, Lencz T, Malhotra AK, Siever LJ, Bitsios P, Haroutunian V. Convergent findings for abnormalities of the NF-κB signaling pathway in schizophrenia. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 2013 Feb; 38(3).
Kozlenkov A, Roussos P, Timashpolsky A, Barbu M, Rudchenko S, Bibikova M, Klotzle B, Byne W, Lyddon R, Di Narzo AF, Hurd YL, Koonin EV, Dracheva S. Differences in DNA methylation between human neuronal and glial cells are concentrated in enhancers and non-CpG sites. Nucleic acids research 2014 Jan; 42(1).
Purcell SM, Morgan JL, Fromer M, Ruderfer D, Solovieff N, Roussos P, O'Dushlaine C, Chambert K, Bergen SE, Kahler A, Duncan L, Stahl E, Genovese G, Fernandez E, Collins MO, Komiyama NH, Choudhary JS, Magnusson PK, Banks E, Shakir K, Garimella K, Fennell T, de Pristo M, Grant S, Haggarty S, Gabriel S, Scolnik EM, Lander ES, Hultman C, Sullivan P, Carroll S, Sklar P. A burden of ultra-rare disruptive mutations concentrated in synaptic gene networks increases risk of schizophrenia. Nature 2014;.