Philippe M Soriano, PhD
- PROFESSOR | Cell, Developmental & Regenerative Biology
- PROFESSOR | Oncological Sciences
Research Topics:Cancer Genetics, Cell Biology, Developmental Biology, Embryology, Genetics, Growth Factors and Receptors, Human Genetics and Genetic Disorders, Knockout Mice, Oncogenes, Organogenesis, Protein Kinases, Skeletal Biology, Stem Cells, Transgenic Mice
Our laboratory is interested in the general question of how biological specificity is acquired upon engagement of growth factor signaling. A major focus of our research is in craniofacial biology, where we seek to identify the pathways by which Platelet Derived Growth Factor (PDGF) and Fibroblast Growth Factor (FGF) signaling in multipotent neural crest cells regulate the development of the midface. We are also studying the signaling pathways engaged by FGFs that govern the establishment of stem cell fates in the early embryo. For more detailed information on our research activities, please consult the laboratory website.
Multi-Disciplinary Training AreasCancer Biology [CAB], Developmental and Stem Cell Biology [DSCB], Neuroscience [NEU]
PhD, University of Paris
Postdoctoral, Whitehead Institute, Massachusetts Institute of Technology
Edwin G. Conklin Medal, Society for Developmental Biology
Editor, Developmental Biology
NIH MERIT Award
Pew Scholar in the Biomedical Sciences
Assistant Investigator, Howard Hughes Medical Institute
Distinct Requirements for FGFR1 and FGFR2 in Primitive Endoderm Development and Exit from Pluripotency. Developmental Cell 2017; 41: 511-526.
Fantauzzo KA, Soriano P. PDGFRβ regulates craniofacial development through homodimers and functional heterodimers with PDGFRα. Genes & Development 2016; 30: 2443-2458.
Brewer JR, Mazot P, Soriano P. Genetic insights into the mechanisms of Fgf signaling [review]. Genes & Development 2016; 30: 751-771.
Brewer JR, Molotkov A, Mazot P, Hoch RV, Soriano P. Fgfr1 regulates development through the combinatorial use of signaling proteins. Genes & Development 2015; 29: 1863-1874.
Vasudevan HN, Mazot P, He F, Soriano P. Receptor tyrosine kinases modulate distinct transcriptional programs by differential usage of intracellular pathways. eLife 2015; 4: e07186.
Vasudevan HN, Soriano P. SRF Regulates Craniofacial Development through Selective Recruitment of MRTF Cofactors by PDGF Signaling. Developmental Cell 2014; 31: 332-344.
Fantauzzo KA, Soriano P. PI3K-mediated PDGFRα signaling regulates survival and proliferation in skeletal development through p53-dependent intracellular pathways. Genes & Development 2014; 28: 1005-1017.
Olson LE, Soriano P. PDGFRβ Signaling Regulates Mural Cell Plasticity and Inhibits Fat Development. Developmental Cell 2011; 20: 815-826.
Bush JO, Soriano P. Ephrin-B1 forward signaling regulates craniofacial morphogenesis by controlling cell proliferation across Eph-ephrin boundaries. Genes & Development 2010; 24: 2068-2080.
Olson LE, Soriano P. Increased PDGFRα activation disrupts connective tissue development and drives systemic fibrosis . Developmental Cell 2009; 16: 303-313.