Pin-Xian Xu, PhD
- PROFESSOR | Genetics and Genomic Sciences
- PROFESSOR | Cell, Developmental & Regenerative Biology
Research Topics:Auditory, Developmental Biology, Epigenetics, Gene Regulation, Genetics, Genomics, Human Genetics and Genetic Disorders, Inner Ear, Kidney, Knockout Mice, Neuroscience, Organogenesis, Protein Phosphatases, Regeneration
Multi-Disciplinary Training AreasDevelopment, Regeneration, and Stem Cells [DRS], Genetics and Data Science [GDS], Neuroscience [NEU]
PhD, The Graduate University for Advanced Studies, Japan
Postdoctoral fellow, Harvard Medical School/Brigham & Women's Hospital
Recipient of 50th Anniversary Program for Scholars in Medicine Fellowship
Individual National Research Service Award
Pin-Xian Xu’s laboratory studies regulatory networks that drive organogenesis. In particular, our lab is interested in the general question of how cell diversity in our body is created. A major focus of our research is auditory and renal development and maintenance, where we seek to identify the pathways by which EYA1 drives a small group of progenitor cells to become functional sensory neurons and hair cells in the inner ear or nephrons in the kidney. For more detailed information, please consult our lab website.
Zhang H, Wang L, Wong EY, Tsang SL, Xu PX, Lendahl U, Sham MH. An Eya1-Notch axis specifies bipotential epibranchial differentiation in mammalian craniofacial morphogenesis. eLife 2017 Nov; 6.
Zhang T, Xu J, Maire P, Xu PX. Six1 is essential for differentiation and patterning of the mammalian auditory sensory epithelium. PLoS genetics 2017 Sep; 13(9).
Xu J, Ueno H, Xu CY, Chen B, Weissman IL, Xu PX. Identification of mouse cochlear progenitors that develop hair and supporting cells in the organ of Corti. Nature communications 2017 May; 8.
Li J, Rodriguez Y, Cheng C, Zeng L, Wong EY, Xu CY, Zhou MM, Xu PX. EYA1's Conformation Specificity in Dephosphorylating Phosphothreonine in Myc and Its Activity on Myc Stabilization in Breast Cancer. Molecular and cellular biology 2017 Jan; 37(1).
Wong EY, Xu CY, Brahmachary M, Xu PX. A Novel ENU-Induced Mutation in Myo6 Causes Vestibular Dysfunction and Deafness. PloS one 2016; 11(5).
Eisner A, Pazyra-Murphy MF, Durresi E, Zhou P, Zhao X, Chadwick EC, Xu PX, Hillman RT, Scott MP, Greenberg ME, Segal RA. The Eya1 phosphatase promotes Shh signaling during hindbrain development and oncogenesis. Dev cell 2015 Apr; 2(1).
Xu J, Xu PX. Eya-six are necessary for survival of nephrogenic cord progenitors and inducing nephric duct development before ureteric bud formation. Dev Dyn 2015 Jul; 244(7).
Xu J, Wong EY, Cheng C, Li J, Sharkar MT, Xu CY, Chen B, Sun J, Jin D, Xu PX. Eya1 interacts with Six2 and Myc to regulate expansion of the nephron progenitor pool during nephrogenesis. Dev Cell 2014 Nov; 31(4).
Yan J, Zhang L, Xu J, Sultana N, Hu J, Cai X, Li J, Xu PX, Cai CL. Smad4 regulates ureteral smooth muscle cell differentiation during mouse embryogenesis. PLoS One 2014 Aug; 9(8).
Xu J, Nie X, Cai X, Cai CL, Xu PX. Tbx18 is essential for normal development of vasculature network and glomerular mesangium in the mammalian kidney. Dev Biol 2014 Jul; 391(1).
Bao S, Zhu L, Zhuang Q, Wang L, Xu PX, Itoh K, Holzman IR, Lin J. Distribution dynamics of recombinant Lactobacillus in the gastrointestinal tract of neonatal rats. PloS One 2013 Mar; 8(3).
Sun J, Karoulia Z, Wong EY, Ahmed M, Itoh K, Xu PX. The phosphatase-transcription activator EYA1 is targeted by anaphase-promoting complex/Cdh1 for degradation at M-to-G1 transition. Mol Cell Biol 2013 Mar; 33(5).
Wong EY, Ahmed M, Xu PX. EYA1-SIX1 complex in neurosensory cell fate induction in the mammalian inner ear. Hear Res 2013 Mar; 297.
Xu PX. The EYA-SO/SIX complex in development and disease. Pediatr Nephrol 2013 Jun; 28(6).
Rinkevich Y, Mori T, Sahoo D, Xu PX, Bermingham JR, Weissman IL. Identification and prospective isolation of a mesothelial precursor lineage giving rise to smooth muscle cells and fibroblasts for mammalian internal organs, and their vasculature. Nat Cell Biol 2012 Dec; 14(12).
Ahmed M, Xu J, Xu PX. EYA1 and SIX1 drive the neuronal developmental program in cooperation with the SWI/SNF chromatin-remodeling complex and SOX2 in the mammalian inner ear. Development 2012 Jun; 139(11).
Ahmed M, Wong EY, Sun J, Xu J, Wang F, Xu PX. Eya1-Six1 interaction is sufficient to induce hair cell fate in the cochlea by activating Atoh1 expression in cooperation with Sox2. Dev Cell 2012 Feb; 22(2).
Nie X, Xu J, El-Hashash A, Xu PX. Six1 regulates Grem1 expression in the metanephric mesenchyme to initiate branching morphogenesis. Dev Biol 2011 Apr; 352(1).
Nie X, Sun J, Gordon RE, Cai CL, Xu PX. SIX1 acts synergistically with TBX18 in mediating ureteral smooth muscle formation. Development 2010 Mar; 137(5).