Pin-Xian Xu | Mount Sinai

Biography

Research Topics

Auditory, Developmental Biology, Epigenetics, Gene Regulation, Genetics, Genomics, Human Genetics and Genetic Disorders, Inner Ear, Kidney, Knockout Mice, Neuroscience, Organogenesis, Protein Phosphatases, Regeneration

Multi-Disciplinary Training Area

Development Regeneration and Stem Cells [DRS], Genetics and Genomic Sciences [GGS]

Research

Pin-Xian Xu’s laboratory studies regulatory networks that drive organogenesis. In particular, our lab is interested in the general question of how cell diversity in our body is created. A major focus of our research is auditory and renal development and maintenance, where we seek to identify the pathways by which EYA1 drives a small group of progenitor cells to become functional sensory neurons and hair cells in the inner ear or nephrons in the kidney. For more detailed information, please consult our lab website.

Education

PhD, The Graduate University for Advanced Studies, Japan

Postdoctoral fellow, Harvard Medical School/Brigham & Women's Hospital

Honors & Awards

2007

Member

NIH Scientific Review Group UKGD

2000

Research Award

National Science Foundation

1999

Recipient of 50th Anniversary Program for Scholars in Medicine Fellowship

Harvard Medical School

1997

Individual National Research Service Award

National Eye Institute/NIH

Publications

60

Publications

Selected Publications

Smarca4 deficiency induces Pttg1 oncogene upregulation and hyperproliferation of tubular and interstitial cells during kidney development. Jinshu Xu, Xianxiao Zhou, Ting Zhang, Bin Zhang, Pin Xian Xu. Frontiers in Cell and Developmental Biology

The role of Eya1 and Eya2 in the taste system of mice from embryonic stage to adulthood. Ting Zhang, Pin Xian Xu. Frontiers in Cell and Developmental Biology

The transcriptional coactivator Eya1 exerts transcriptional repressive activity by interacting with REST corepressors and REST-binding sequences to maintain nephron progenitor identity. Jun Li, Chunming Cheng, Jinshu Xu, Ting Zhang, Bengu Tokat, Georgia Dolios, Aarthi Ramakrishnan, Li Shen, Rong Wang, Pin Xian Xu. Nucleic Acids Research

View All Publications

Office Locations

Icahn (East) Building Floor 14 Room 14-20D

1425 Madison Ave

New York, NY 10029

212-659-6787

Industry Relationships

Physicians and scientists on the faculty of the Icahn School of Medicine at Mount Sinai often interact with pharmaceutical, device, biotechnology companies, and other outside entities to improve patient care, develop new therapies and achieve scientific breakthroughs. In order to promote an ethical and transparent environment for conducting research, providing clinical care and teaching, Mount Sinai requires that salaried faculty inform the School of their outside financial relationships.

Dr. Xu has not yet completed reporting of Industry relationships.

Mount Sinai's faculty policies relating to faculty collaboration with industry are posted on our website. Patients may wish to ask their physician about the activities they perform for companies.

Physicians and scientists on the faculty of the Icahn School of Medicine at Mount Sinai often interact with pharmaceutical, device, biotechnology companies, and other outside entities to improve patient care, develop new therapies and achieve scientific breakthroughs. In order to promote an ethical and transparent environment for conducting research, providing clinical care and teaching, Mount Sinai requires that salaried faculty inform the School of their outside financial relationships.

Dr. Xu has not yet completed reporting of Industry relationships.

Mount Sinai's faculty policies relating to faculty collaboration with industry are posted on our website. Patients may wish to ask their physician about the activities they perform for companies.