Randy A Albrecht, PhD
- ASSOCIATE PROFESSOR | Microbiology
Research Topics:Biodefense, Cellular Immunity, Cytokines, Epithelial Cells, Immune Antagonism, Immunology, Infectious Disease, Influenza Virus, Interferon Antagonists, Lung, Molecular Biology, Mucosal Immunology, Paramyxovirus, Vaccine Development
Specific Research Interests: Host-Pathogen Interactions, Vaccine Development
My research focuses on host-pathogen interactions involving respiratory viruses. More specifically, I am interested in studying the replication, pathogenesis, and transmission of respiratory viruses. Areas of research include studies on humoral responses to influenza vaccines, development of model systems to study the effectiveness of vaccines against respiratory viruses, studies on virus regulation of innate and adaptive immune responses, and studies examining adaptation of viruses to new hosts.
PhD, Louisiana State University Health Sciences Center Shreveport
Langlois RA, Albrecht RA, Kimble B, Sutton T, Shapiro JS, Finch C, Angel M, Chua MA, Gonzalez-Reiche AS, Xu K, Perez D, García-Sastre A, tenOever BR. MicroRNA-based strategy to mitigate the risk of gain-of-function influenza studies. Nature biotechnology 2013 Sep; 31(9).
Rajsbaum R, Albrecht RA, Wang MK, Maharaj NP, Versteeg GA, Nistal-Villán E, García-Sastre A, Gack MU. Species-specific inhibition of RIG-I ubiquitination and IFN induction by the influenza A virus NS1 protein. PLoS pathogens 2012; 8(11).
Varble A, Albrecht RA, Backes S, Crumiller M, Bouvier NM, Sachs D, García-Sastre A, tenOever BR. Influenza A virus transmission bottlenecks are defined by infection route and recipient host. Cell host & microbe 2014 Nov; 16(5).
Sasaki S, Holmes TH, Albrecht RA, García-Sastre A, Dekker CL, He XS, Greenberg HB. Distinct cross-reactive B-cell responses to live attenuated and inactivated influenza vaccines. The Journal of infectious diseases 2014 Sep; 210(6).
Silvin A, Yu CI, Lahaye X, Imperatore F, Brault JB, Cardinaud S, Becker C, Kwan WH, Conrad C, Maurin M, Goudot C, Marques-Ladeira S, Wang Y, Pascual V, Anguiano E, Albrecht RA, Iannacone M, García-Sastre A, Goud B, Dalod M, Moris A, Merad M, Palucka AK, Manel N. Constitutive resistance to viral infection in human CD141(+) dendritic cells. Science immunology 2017 Jul; 2(13).
Bentebibel SE, Khurana S, Schmitt N, Kurup P, Mueller C, Obermoser G, Palucka AK, Albrecht RA, Garcia-Sastre A, Golding H, Ueno H. ICOS(+)PD-1(+)CXCR3(+) T follicular helper cells contribute to the generation of high-avidity antibodies following influenza vaccination. Scientific reports 2016 May; 6.
Tundup S, Kandasamy M, Perez JT, Mena N, Steel J, Nagy T, Albrecht RA, Manicassamy B. Endothelial cell tropism is a determinant of H5N1 pathogenesis in mammalian species. PLoS pathogens 2017 Mar; 13(3).
DiPiazza A, Richards K, Batarse F, Lockard L, Zeng H, García-Sastre A, Albrecht RA, Sant AJ. Flow Cytometric and Cytokine ELISpot Approaches To Characterize the Cell-Mediated Immune Response in Ferrets following Influenza Virus Infection. Journal of virology 2016 Sep; 90(17).
Thornburg NJ, Zhang H, Bangaru S, Sapparapu G, Kose N, Lampley RM, Bombardi RG, Yu Y, Graham S, Branchizio A, Yoder SM, Rock MT, Creech CB, Edwards KM, Lee D, Li S, Wilson IA, García-Sastre A, Albrecht RA, Crowe JE. H7N9 influenza virus neutralizing antibodies that possess few somatic mutations. The Journal of clinical investigation 2016 Apr; 126(4).