Robert O Wright, MD
- PROFESSOR AND SYSTEM CHAIR | Environmental Medicine & Public Health
- PROFESSOR | Pediatrics
Research Topics:Biostatistics, Epigenetics
Dr. Robert Wright is a pediatrician, medical toxicologist, and environmental epidemiologist at the Icahn School of Medicine at Mount Sinai. He is the Ethel H Wise Chair of the Department of Environmental Medicine and Public Health (Formerly the Department of Preventive Medicine), Director of the new Institute for Exposomic Research and Principal Investigator of an ongoing longitudinal birth cohort in Mexico City (Programming Research in Obesity, Growth, Environment and Social Stress--PROGRESS) in collaboration with the National Institute of Public Health, Mexico. He also founded the (Metals Assessment Targeting Community Health) MATCH study in Tar Creek, Oklahoma.
Beginning in September 2018, he will join the National Advisory Environmental Health Sciences Council (NAEHSC), a Congressionally mandated body that advises the secretary of Health and Human Services, the director of NIH, and the director of the National Institute of Environmental Health Sciences (NIEHS) on matters relating to the direction of research, research support, training, and career development supported by the NIEHS.
Dr. Wright studies chemical mixtures, social stressors as a modifier of chemical toxicity, and the role of genetics/epigenetics in modifying or mediating chemical toxicity. He is an international advocate for research on Exposomics- the measure of all health relevant human exposure throughout the lifespan. He has published over 200 research studies, most of which deal with Environmental Health and has served on numerous international and national committee/advisory boards. Dr. Wright founded and directs the Senator Frank Lautenberg Laboratory of Environmental Health Sciences at Mount Sinai. He is a graduate of the University of Michigan Medical School and completed residency in Pediatrics at Northwestern University, as well as the following fellowships: Emergency Medicine, (Brown University), Medical Toxicology (Harvard University), Environmental Epidemiology, (Harvard University) and Genetic Epidemiology (Harvard University). Finally, he also established the Mount Sinai Transdisciplinary Center on Early Environmental Exposures- a NIH funded Core Center grant program that provides infrastructure support to Mount Sinai environmental researchers.
Multi-Disciplinary Training AreaNeuroscience [NEU]
BS, University of Michigan-Dearborn
MD, University of Michigan
MPH, Harvard School of Public Health
Young Investigator Award, Society for Academic Emergency Medicine
Charlotte Promersberger Johnston Endowed Lectureship, Medical College of Wisconsin-Milwaukee
Dr. Robert Wright’s research focuses on environmental factors which influence child health and neurodevelopment. He is specifically interested in chemical mixtures and exposomic approaches to study neurodevelopment and reproductive health. His research combines state of the art research techniques in both environmental health, exposure science, and epigenetic epidemiology. As an interdisciplinary scientist, he bridges the communication gap between these fields and is leading the design and conduct of sophisticated epidemiologic research in children’s environmental health. He has been the PI of multiple NIH RO1’s (R01 ES013744, R01ES020268, R01ES021357, R01ES026033) supporting epidemiologic cohort studies in Mexico City. He is the director and founder of the Mount Sinai P30 Core Center in Transdisciplinary Environmental Health Research and the Mount Sinai CHEAR (Child Health Exposure Analysis Resource) Lab Hub. Before joining Mount Sinai he directed an NIH funded Superfund Program Project grant (P42 ES016454). He founded and leads the Senator Frank Lautenberg Laboratory in Environmental Health Sciences and the newly established Mount Sinai Institute for Exposomic Research.
Haynes EN, Sucharew H, Hilbert TJ, Kuhnell P, Spencer A, Newman NC, Burns R, Wright R, Parsons PJ, Dietrich KN. Impact of air manganese on child neurodevelopment in East Liverpool, Ohio. Neurotoxicology 2018 Jan; 64.
Wright RO. Environment, susceptibility windows, development, and child health. Curr Opin Pediatr 2017 Apr; 29(2): 211-217.
Muñoz-Rocha TV, Tamayo Y Ortiz M, Romero M, Pantic I, Schnaas L, Bellinger D, Claus-Henn B, Wright R, Wright RO, Téllez-Rojo MM. Prenatal co-exposure to manganese and depression and 24-months neurodevelopment. Neurotoxicology 2018 Jan; 64.
Rosa MJ, Just AC, Guerra MS, Kloog I, Hsu HL, Brennan KJ, Garcia AM, Coull B, Wright RJ, Tellez Rojo MM, Baccarelli AA, Wright RO. Identifying sensitive windows for prenatal particulate air pollution exposure and mitochondrial DNA content in cord blood. Environ Int 2017 Jan; 98: 198-203.
Knight AK, Craig JM, Theda C, Bækvad-Hansen M, Bybjerg-Grauholm J, Hansen CS, Hollegaard MV, Hougaard DM, Mortensen PB, Weinsheimer SM, Werge TM, Brennan PA, Cubells JF, Newport DJ, Stowe ZN, Cheong JL, Dalach P, Doyle LW, Loke YJ, Baccarelli AA, Just AC, Wright RO, Téllez-Rojo MM, Svensson K, Trevisi L, Kennedy EM, Binder EB, Iurato S, Czamara D, Räikkönen K, Lahti JM, Pesonen AK, Kajantie E, Villa PM, Laivuori H, Hämäläinen E, Park HJ, Bailey LB, Parets SE, Kilaru V, Menon R, Horvath S, Bush NR, LeWinn KZ, Tylavsky FA, Conneely KN, Smith AK. An epigenetic clock for gestational age at birth based on blood methylation data. Genome biology 2016 Oct; 17(1).
Wahlberg K, Arora M, Curtin A, Curtin P, Wright RO, Smith DR, Lucchini RG, Broberg K, Austin C. Polymorphisms in manganese transporters show developmental stage and sex specific associations with manganese concentrations in primary teeth. Neurotoxicology 2018 Jan; 64.
Wagner PJ, Park HR, Wang Z, Kirchner R, Wei Y, Su L, Stanfield K, Guilarte TR, Wright RO, Christiani DC, Lu Q. In Vitro Effects of Lead on Gene Expression in Neural Stem Cells and Associations between Upregulated Genes and Cognitive Scores in Children. Environmental health perspectives 2016 Aug;.
Lee A, Leon Hsu HH, Mathilda Chiu YH, Bose S, Rosa MJ, Kloog I, Wilson A, Schwartz J, Cohen S, Coull BA, Wright RO, Wright RJ. Prenatal fine particulate exposure and early childhood asthma: Effect of maternal stress and fetal sex. The Journal of allergy and clinical immunology 2018 May; 141(5).
Karlsson O, Rodosthenous RS, Jara C, Brennan KJ, Wright RO, Baccarelli AA, Wright RJ. Detection of long non-coding RNAs in human breastmilk extracellular vesicles: Implications for early child development. Epigenetics 2016 Aug;.
de Water E, Proal E, Wang V, Medina SM, Schnaas L, Téllez-Rojo MM, Wright RO, Tang CY, Horton MK. Prenatal manganese exposure and intrinsic functional connectivity of emotional brain areas in children. Neurotoxicology 2018 Jan; 64.
Oken E, Rifas-Shiman SL, Amarasiriwardena C, Jayawardene I, Bellinger DC, Hibbeln JR, Wright RO, Gillman MW. Maternal prenatal fish consumption and cognition in mid childhood: Mercury, fatty acids, and selenium. Neurotoxicology and teratology 2016 Jul;.
Prada D, Colicino E, Power MC, Weisskopf MG, Zhong J, Hou L, Spiro A, Vokonas P, Brennan K, Herrera LA, Schwartz J, Wright R, Hu H, Baccarelli AA. Corrigendum to . Environmental research 2018 Aug; 165.
Wright RO, Teitelbaum S, Thompson C, Balshaw D. The child health exposure analysis resource as a vehicle to measure environment in the environmental influences on child health outcomes program. Current opinion in pediatrics 2018 Apr; 30(2).
Stroustrup A, Hsu HH, Svensson K, Schnaas L, Cantoral A, Solano González M, Torres-Calapiz M, Amarasiriwardena C, Bellinger DC, Coull BA, Téllez-Rojo MM, Wright RO, Wright RJ. Toddler temperament and prenatal exposure to lead and maternal depression. Environmental health : a global access science source 2016 Jun; 15(1).
Lee AG, Le Grand B, Hsu HL, Chiu YM, Brennan KJ, Bose S, Rosa MJ, Brunst KJ, Kloog I, Wilson A, Schwartz J, Morgan W, Coull BA, Wright RO, Baccarelli AA, Wright RJ. Prenatal fine particulate exposure associated with reduced childhood lung function and nasal epithelia GSTP1 hypermethylation: Sex-specific effects. Respiratory research 2018 04; 19(1).
Kappil M, Wright RO, Sanders AP. Developmental Origins of Common Disease: Epigenetic Contributions to Obesity. Annual review of genomics and human genetics 2016 May;.
Curtin P, Austin C, Curtin A, Gennings C, Arora M, Tammimies K, Willfors C, Berggren S, Siper P, Rai D, Meyering K, Kolevzon A, Mollon J, David AS, Lewis G, Zammit S, Heilbrun L, Palmer RF, Wright RO, Bölte S, Reichenberg A. Dynamical features in fetal and postnatal zinc-copper metabolic cycles predict the emergence of autism spectrum disorder. Science advances 2018 May; 4(5).
Rodrigues EG, Bellinger DC, Valeri L, Hasan MO, Quamruzzaman Q, Golam M, Kile ML, Christiani DC, Wright RO, Mazumdar M. Neurodevelopmental outcomes among 2- to 3-year-old children in Bangladesh with elevated blood lead and exposure to arsenic and manganese in drinking water. Environmental health : a global access science source 2016 Mar; 15(1).
Brunst KJ, Sanchez-Guerra M, Chiu YM, Wilson A, Coull BA, Kloog I, Schwartz J, Brennan KJ, Bosquet Enlow M, Wright RO, Baccarelli AA, Wright RJ. Prenatal particulate matter exposure and mitochondrial dysfunction at the maternal-fetal interface: Effect modification by maternal lifetime trauma and child sex. Environment international 2018 Mar; 112.
Niedzwiecki MM, Austin C, Remark R, Merad M, Gnjatic S, Estrada-Gutierrez G, Espejel-Nuñez A, Borboa-Olivares H, Guzman-Huerta M, Wright RJ, Wright RO, Arora M. A multimodal imaging workflow to visualize metal mixtures in the human placenta and explore colocalization with biological response markers. Metallomics : integrated biometal science 2016 Mar;.
Lee A, Mathilda Chiu YH, Rosa MJ, Jara C, Wright RO, Coull BA, Wright RJ. Prenatal and postnatal stress and asthma in children: Temporal- and sex-specific associations. The Journal of allergy and clinical immunology 2016 Mar;.
Wu S, Gennings C, Wright RJ, Wilson A, Burris HH, Just AC, Braun JM, Svensson K, Zhong J, Brennan KJ, Dereix A, Cantoral A, Schnaas L, Téllez-Rojo MM, Wright RO, Baccarelli AA. Prenatal Stress, Methylation in Inflammation-Related Genes, and Adiposity Measures in Early Childhood: the Programming Research in Obesity, Growth Environment and Social Stress Cohort Study. Psychosomatic medicine 2018 Jan; 80(1).
Flom JD, Chiu YM, Tamayo-Ortiz M, Schnaas L, Curtin PC, Wright RJ, Wright RO, Téllez-Rojo MM, Rosa MJ. Subconstructs of the Edinburgh Postpartum Depression Scale in a postpartum sample in Mexico City. Journal of affective disorders 2018 Oct; 238.
Tamayo Y Ortiz M, Téllez-Rojo MM, Wright RJ, Coull BA, Wright RO. Longitudinal associations of age and prenatal lead exposure on cortisol secretion of 12-24 month-old infants from Mexico City. Environmental health : a global access science source 2016 Feb; 15(1).
Claus Henn B, Ettinger AS, Hopkins MR, Jim R, Amarasiriwardena C, Christiani DC, Coull BA, Bellinger DC, Wright RO. Prenatal Arsenic Exposure and Birth Outcomes among a Population Residing near a Mining-Related Superfund Site. Environmental health perspectives 2016 Feb;.
Claus Henn B, Austin C, Coull BA, Schnaas L, Gennings C, Horton MK, Hernández-Ávila M, Hu H, Téllez-Rojo MM, Wright RO, Arora M. Uncovering neurodevelopmental windows of susceptibility to manganese exposure using dentine microspatial analyses. Environmental research 2018 Feb; 161.
Haynes EN, Elam S, Burns R, Spencer A, Yancey E, Kuhnell P, Alden J, Walton M, Reynolds V, Newman N, Wright RO, Parsons PJ, Praamsma ML, Palmer CD, Dietrich KN. Community Engagement and Data Disclosure in Environmental Health Research. Environmental health perspectives 2016 Feb; 124(2).
Sanders AP, Saland JM, Wright RO, Satlin L. Perinatal and childhood exposure to environmental chemicals and blood pressure in children: a review of literature 2007-2017. Pediatric research 2018 Jun;.
Rosa MJ, Just AC, Tamayo Y Ortiz M, Schnaas L, Svensson K, Wright RO, Téllez Rojo MM, Wright RJ. Prenatal and postnatal stress and wheeze in Mexican children: Sex-specific differences. Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology 2016 Jan;.
Austin C, Smith TM, Farahani RM, Hinde K, Carter EA, Lee J, Lay PA, Kennedy BJ, Sarrafpour B, Wright RJ, Wright RO, Arora M. Uncovering system-specific stress signatures in primate teeth with multimodal imaging. Scientific reports 2016 Jan; 6.
Zota AR, Riederer AM, Ettinger AS, Schaider LA, Shine JP, Amarasiriwardena CJ, Wright RO, Spengler JD. Associations between metals in residential environmental media and exposure biomarkers over time in infants living near a mining-impacted site. Journal of exposure science & environmental epidemiology 2015 Dec;.
Huang S, Hu H, Sánchez BN, Peterson KE, Ettinger AS, Lamadrid-Figueroa H, Schnaas L, Mercado-García A, Wright RO, Basu N, Cantonwine DE, Hernández-Avila M, Téllez-Rojo MM. Childhood Blood Lead Levels and Symptoms of Attention Deficit Hyperactivity Disorder (ADHD): A Cross-Sectional Study of Mexican Children. Environmental health perspectives 2015 Dec;.
Chiu YM, Hsu HL, Coull BA, Bellinger DC, Kloog I, Schwartz J, Wright RO, Wright RJ. Prenatal particulate air pollution and neurodevelopment in urban children: Examining sensitive windows and sex-specific associations. Environment international 2015 Nov; 87.
Cowell WJ, Bellinger DC, Coull BA, Gennings C, Wright RO, Wright RJ. Associations between Prenatal Exposure to Black Carbon and Memory Domains in Urban Children: Modification by Sex and Prenatal Stress. PloS one 2015 Nov; 10(11).
Cardenas A, Houseman EA, Baccarelli AA, Quamruzzaman Q, Rahman M, Mostofa G, Wright RO, Christiani DC, Kile ML. In utero arsenic exposure and epigenome-wide associations in placenta, umbilical artery, and human umbilical vein endothelial cells. Epigenetics 2015 Nov; 10(11).
Schreier HM, Bosquet Enlow M, Ritz T, Coull BA, Gennings C, Wright RO, Wright RJ. Lifetime Exposure to Traumatic and Other Stressful Life Events and Hair Cortisol in a Multi-Racial/Ethnic Sample of Pregnant Women. Stress (Amsterdam, Netherlands) 2015 Nov;.
Burris HH, Baccarelli AA, Wright RO, Wright RJ. Epigenetics, linking social and environmental exposures to preterm birth. Pediatric research 2015 Oct;.
Sanders AP, Burris HH, Just AC, Motta V, Amarasiriwardena C, Svensson K, Oken E, Solano-Gonzalez M, Mercado-Garcia A, Pantic I, Schwartz J, Tellez-Rojo MM, Baccarelli AA, Wright RO. Altered miRNA expression in the cervix during pregnancy associated with lead and mercury exposure. Epigenomics 2015 Sep;.
Sanders AP, Claus Henn B, Wright RO. Perinatal and Childhood Exposure to Cadmium, Manganese, and Metal Mixtures and Effects on Cognition and Behavior: A Review of Recent Literature. Current environmental health reports 2015 Sep; 2(3).
Burris HH, Baccarelli AA, Byun HM, Cantoral A, Just AC, Pantic I, Solano-Gonzalez M, Svensson K, Ortiz MT, Zhao Y, Wright RO, Téllez-Rojo MM. Offspring DNA methylation of the aryl-hydrocarbon receptor repressor gene is associated with maternal BMI, gestational age, and birth weight. Epigenetics 2015 Aug;.
Just AC, Wright RO, Schwartz J, Coull BA, Baccarelli AA, Tellez-Rojo MM, Moody E, Wang Y, Lyapustin A, Kloog I. Using High-Resolution Satellite Aerosol Optical Depth To Estimate Daily PM2.5 Geographical Distribution in Mexico City. Environmental science & technology 2015 Jul; 49(14).
Hsu HL, Chiu YM, Coull BA, Kloog I, Schwartz J, Lee A, Wright RO, Wright RJ. Prenatal Particulate Air Pollution and Asthma Onset in Urban Children: Identifying Sensitive Windows and Sex Differences. American journal of respiratory and critical care medicine 2015 Jul;.
Bobb JF, Valeri L, Claus Henn B, Christiani DC, Wright RO, Mazumdar M, Godleski JJ, Coull BA. Bayesian kernel machine regression for estimating the health effects of multi-pollutant mixtures. Biostatistics (Oxford, England) 2015 Jul; 16(3).
Andra SS, Austin C, Wright RO, Arora M. Reconstructing pre-natal and early childhood exposure to multi-class organic chemicals using teeth: Towards a retrospective temporal exposome. Environment International 2015 Jun; 83: 137-145.
Just AC, Wright RO, Schwartz J, Coull BA, Baccarelli A, Tellez-Rojo MM, Moody E, Wang Y, Lyapustin A, Kloog I. Using high-resolution satellite aerosol optical depth to estimate daily PM2.5 geographical distribution in Mexico City. Environmental science & technology 2015 Jun;.
Brunst KJ, Baccarelli AA, Wright RJ. Integrating mitochondriomics in children's environmental health. Journal of applied toxicology : JAT 2015 Jun;.
Haynes EN, Sucharew H, Kuhnell P, Alden J, Barnas M, Wright RO, Parsons PJ, Aldous KM, Praamsma ML, Beidler C, Dietrich KN. Manganese Exposure and Neurocognitive Outcomes in Rural School-Age Children: The Communities Actively Researching Exposure Study (Ohio, USA). Environmental health perspectives 2015 Apr;.
Schreier HM, Hsu HH, Amarasiriwardena C, Coull BA, Schnaas L, Téllez-Rojo MM, Tamayo Y Ortiz M, Wright RJ, Wright RO. Mercury and psychosocial stress exposure interact to predict maternal diurnal cortisol during pregnancy. Environmental health : a global access science source 2015 Mar; 14(1).
Lakshmanan A, Chiu YH, Coull BA, Just AC, Maxwell SL, Schwartz J, Gryparis A, Kloog I, Wright RJ, Wright RO. Associations between prenatal traffic-related air pollution exposure and birth weight: Modification by sex and maternal pre-pregnancy body mass index. Environmental research 2015 Feb; 137.
Sanders AP, Burris HH, Just AC, Motta V, Svensson K, Mercado-Garcia A, Pantic I, Schwartz J, Tellez-Rojo MM, Wright RO, Baccarelli AA. microRNA expression in the cervix during pregnancy is associated with length of gestation. Epigenetics 2015 Jan; 10(3).
Perkins M, Wright RO, Amarasiriwardena CJ, Jayawardene I, Rifas-Shiman SL, Oken E. Very low maternal lead level in pregnancy and birth outcomes in an eastern Massachusetts population. Annals of epidemiology 2014 Dec; 24(12).