Robert S Krauss, PhD
- PROFESSOR | Cell, Developmental & Regenerative Biology
- PROFESSOR | Oncological Sciences
Research Topics:
Cell Adhesion, Cell Biology, Cellular Differentiation, Cytoskeleton, Developmental Biology, Developmental Neurobiology, Genetics, Human Genetics and Genetic Disorders, Knockout Mice, Muscle Cells, Muscular Dystrophy, Protein Kinases, Signal Transduction, Stem CellsEndowed Chair, Mount Sinai Professor in Cell Biology
For more information, please visit the Krauss Laboratory website.
Multi-Disciplinary Training Areas
Cancer Biology [CAB], Development Regeneration and Stem Cells [DRS]Education
PhD, University of North Carolina
Postdoc, Columbia University
-
2010
Editorial Board -
2006
President -
2006
Editorial Board -
2004
Editorial Board -
1999
Established Investigator Award -
1996
Career Scientist Award
The Krauss lab is interested in regulation of cell adhesion and signal transduction pathways during embryonic development and tissue regeneration, and how such processes may go awry in disease. The lab has two major areas of focus.
First, we are interested in development and regeneration of skeletal muscle. We have identified multiprotein cell surface complexes that promote differentiation of skeletal muscle precursor cells in response to cell-cell contact and adhesion. We use a combination of approaches, including mouse genetics, cell biology and biochemistry to probe the biological functions and molecular mechanisms of such complexes in skeletal myogenesis. We have recently turned our attention to how specific cell adhesion molecules regulate the niche and activity of muscle stem cells during homeostasis and regeneration following injury.
We are also interested mechanisms whereby the Hedgehog signaling pathway regulates development of the midline of the forebrain and midface. Mutations in Hedgehog pathway genes are associated with the common and often devastating developmental defect holoprosencephaly (HPE). However, the clinical outcome of mutation carriers is extremely variable, and additional genetic or environmental factors are required for strong defects. Using mouse models of such interactions and functional analyses of human HPE-associated mutations, we aim to provide information on mechanisms of HPE that will be valuable for genetic counseling and preventive action.
For more information, please visit the Krauss Laboratory website.
Physicians and scientists on the faculty of the Icahn School of Medicine at Mount Sinai often interact with pharmaceutical, device and biotechnology companies to improve patient care, develop new therapies and achieve scientific breakthroughs. In order to promote an ethical and transparent environment for conducting research, providing clinical care and teaching, Mount Sinai requires that salaried faculty inform the School of their relationships with such companies.
Dr. Krauss did not report having any of the following types of financial relationships with industry during 2022 and/or 2023: consulting, scientific advisory board, industry-sponsored lectures, service on Board of Directors, participation on industry-sponsored committees, equity ownership valued at greater than 5% of a publicly traded company or any value in a privately held company. Please note that this information may differ from information posted on corporate sites due to timing or classification differences.
Mount Sinai's faculty policies relating to faculty collaboration with industry are posted on our website. Patients may wish to ask their physician about the activities they perform for companies.