Roger Clem, PhD
- ASSOCIATE PROFESSOR | Neuroscience
- ASSOCIATE PROFESSOR | Psychiatry
Research Topics:Auditory, Behavior, Brain, Cerebral Cortex, Cognitive Neuroscience, Depression, Electrophysiology, Glutamate (NMDA & AMPA) Receptors, Growth Factors and Receptors, Hippocampus, Knockout Mice, Memory, Neural Networks, Neurophysiology, Synaptic Plasticity, Synaptogenesis, Systems Neuroscience
Dr. Clem is an Associate Professor of Neuroscience at the Icahn School of Medicine at Mount Sinai. His research is focused on how experience alters the function of brain circuits to encode emotional responses.
Multi-Disciplinary Training AreaNeuroscience [NEU]
PhD, Carnegie Mellon University
Johns Hopkins University
FBI Research Scholar Award
NARSAD Young Investigator Award
Finalist, Eppendorf and Science Prize for Neurobiology
Daniel Nathans Research Award
National Research Service Award
Emotional Brain Plasticity
Emotional memories mediate adaptive behavioral reactions to dangerous and rewarding situations. However, memories acquired during intense emotional experiences also contribute to debilitating conditions like post-traumatic stress disorder and addiction. One basis for these powerful effects is the association of stimuli that were encountered during trauma or drug use with the experience of threat or pleasure. Our laboratory aims to understand how such associations are stored in the brain, and identify circuit mechanisms by which they can be alleviated.
We utilize a combination of approaches including optogenetics, synaptic electrophysiology and calcium imaging, to identify how neural pathways and individual neurons are engaged and modified during memory storage. Once memories are established, other experiments address the mechanisms that contribute to their reinforcement or attenuation by molecular and behavioral interventions.
Sabina Bayshtok -- Research Associate
Kirstie Cummings, Ph.D. -- Postdoctoral Fellow
Darpan Chakraborty, Ph.D. -- Postdoctoral Fellow
Anthony Lacagnina, Ph.D. -- Postdoctoral Fellow
Ciorana Roman-Ortiz -- Ph.D. student