Roger Clem, PhD
- ASSOCIATE PROFESSOR | Neuroscience
- ASSOCIATE PROFESSOR | Psychiatry
Research Topics:Auditory, Behavior, Brain, Cerebral Cortex, Cognitive Neuroscience, Depression, Electrophysiology, Glutamate (NMDA & AMPA) Receptors, Growth Factors and Receptors, Hippocampus, Knockout Mice, Memory, Neural Networks, Neurophysiology, Synaptic Plasticity, Synaptogenesis, Systems Neuroscience
Dr. Clem is an Associate Professor of Neuroscience at the Icahn School of Medicine at Mount Sinai. His research is focused on how experience alters the function of brain circuits to encode emotional responses.
Multi-Disciplinary Training AreaNeuroscience [NEU]
PhD, Carnegie Mellon University
Johns Hopkins University
FBI Research Scholar Award
NARSAD Young Investigator Award
Finalist, Eppendorf and Science Prize for Neurobiology
Daniel Nathans Research Award
National Research Service Award
Emotional Brain Plasticity
Emotional memories mediate adaptive behavioral reactions to dangerous and rewarding situations. However, memories acquired during intense emotional experiences also contribute to debilitating conditions like post-traumatic stress disorder and addiction. One basis for these powerful effects is the association of stimuli that were encountered during trauma or drug use with the experience of threat or pleasure. Our laboratory aims to understand how such associations are stored in the brain, and identify circuit mechanisms by which they can be alleviated.
We utilize a combination of approaches including optogenetics, synaptic electrophysiology and calcium imaging, to identify how neural pathways and individual neurons are engaged and modified during memory storage. Once memories are established, other experiments address the mechanisms that contribute to their reinforcement or attenuation by molecular and behavioral interventions.
Sabina Bayshtok -- Research Associate
Kirstie Cummings, Ph.D. -- Postdoctoral Fellow
Darpan Chakraborty, Ph.D. -- Postdoctoral Fellow
Anthony Lacagnina, Ph.D. -- Postdoctoral Fellow
Ciorana Roman-Ortiz -- Ph.D. student
Lucas EK, Jegarl AM, Morishita H, Clem RL. Multimodal and Site-Specific Plasticity of Amygdala Parvalbumin Interneurons after Fear Learning. Neuron 2016 Jul;.
Clem RL, Schiller D. New Learning and Unlearning: Strangers or Accomplices in Threat Memory Attenuation?. Trends in neurosciences 2016 May; 39(5).
Arruda-Carvalho M, Clem RL. Prefrontal-amygdala fear networks come into focus. Frontiers in systems neuroscience 2015; 9.
Arruda-Carvalho M, Clem RL. Pathway-Selective Adjustment of Prefrontal-Amygdala Transmission during Fear Encoding. The Journal of neuroscience : the official journal of the Society for Neuroscience 2014 Nov; 34(47).
Lucas EK, Jegarl A, Clem RL. Mice lacking TrkB in parvalbumin-positive cells exhibit sexually dimorphic behavioral phenotypes. Behavioural brain research 2014 Nov; 274.
Steinfurth EC, Kanen JW, Raio CM, Clem RL, Huganir RL, Phelps EA. Young and old Pavlovian fear memories can be modified with extinction training during reconsolidation in humans. Learning & memory (Cold Spring Harbor, N.Y.) 2014 Jul; 21(7).
Sia GM, Clem RL, Huganir RL. The human language-associated gene SRPX2 regulates synapse formation and vocalization in mice. Science 2013 Nov; 342(6161): 987-91.
Anggono V, Clem RL, Huganir RL. PICK1 loss of function occludes homeostatic synaptic scaling. The Journal of neuroscience : the official journal of the Society for Neuroscience 2011 Feb; 31(6).
Gerkin RC, Clem RL, Shruti S, Kass RE, Barth AL. Cortical up state activity is enhanced after seizures: a quantitative analysis. Journal of clinical neurophysiology : official publication of the American Electroencephalographic Society 2010 Dec; 27(6).
Clem RL, Huganir RL. Calcium-permeable AMPA receptor dynamics mediate fear memory erasure. Science (New York, N.Y.) 2010 Nov; 330(6007).
Clem RL, Anggono V, Huganir RL. PICK1 regulates incorporation of calcium-permeable AMPA receptors during cortical synaptic strengthening. The Journal of neuroscience : the official journal of the Society for Neuroscience 2010 May; 30(18).
Tran TS, Rubio ME, Clem RL, Johnson D, Case L, Tessier-Lavigne M, Huganir RL, Ginty DD, Kolodkin AL. Secreted semaphorins control spine distribution and morphogenesis in the postnatal CNS. Nature 2009 Dec; 462(7276).
Shruti S, Clem RL, Barth AL. A seizure-induced gain-of-function in BK channels is associated with elevated firing activity in neocortical pyramidal neurons. Neurobiology of disease 2008 Jun; 30(3).
Clem RL, Celikel T, Barth AL. Ongoing in vivo experience triggers synaptic metaplasticity in the neocortex. Science (New York, N.Y.) 2008 Jan; 319(5859).
Clem RL, Barth A. Pathway-specific trafficking of native AMPARs by in vivo experience. Neuron 2006 Mar; 49(5).
Clump DA, Clem R, Qian Y, Guappone-Koay A, Berrebi AS, Flynn DC. Protein expression levels of the Src activating protein AFAP are developmentally regulated in brain. Journal of Neurobiology 2003 Feb; 54(3).