Stephen Salton, MD, PhD
- PROFESSOR | Neuroscience
- PROFESSOR | Geriatrics and Palliative Medicine
Research Topics:Adipose, Aging, Apoptosis/Cell Death, Axon Guidance, Brain, Cell Adhesion, Chromogranins and Secretogranins, Cognitive Neuroscience, Cytoskeleton, Depression, Diabetes, Growth Cone, Growth Factors and Receptors, Hormones, Memory, Neuropeptides, Neurotrophins, Obesity, Protein Phosphatases, Protein Trafficking & Sorting, Signal Transduction, Synapses
Research in the Salton lab is focused on understanding the mechanisms by which neurotrophic growth factors, including nerve growth factor (NGF) and brain-derived neurotrophic factor (BDNF), regulate nervous system development, adult function, and the response to injury and degenerative disease.
Multi-Disciplinary Training AreaNeuroscience [NEU]
BA, University of Pennsylvania
Fellowship, Columbia Presbyterian and Mount Sinai School of Medicine
Internship and Residency, Bellevue and NYU School of Medicine
MD, New York University
PhD, New York University
NARSAD van Ameringen Investigator
NARSAD Independent Investigator
Irma T. Hirschl Career Scientist
Pew Scholar in the Biomedical Sciences
Pfizer Postdoctoral Fellow
Specific Clinical/Research Interests: Molecular Neuroscience; Neurotrophin Signaling; Neuropeptides; Neural Cell Adhesion Molecules; Obesity; Diabetes; Depression; Major Depressive Disorder; Alzheimer's Disease.
Summary of Research Studies: Our research is focused on understanding the mechanisms by which neurotrophic growth factors, including nerve growth factor (NGF) and brain-derived neurotrophic factor (BDNF), regulate nervous system development and function. BDNF and NGF have been implicated in the pathophysiology of neurodegenerative disease, neuropsychiatric illness, CNS injury, and obesity. The contributions made by specific neurotrophin-regulated gene products to depression, memory, and energy balance, are being being examined using novel knockout, transgenic, and knockin mouse models. The lab has identified VGF, a secreted neuronal and neuroendocrine peptide precursor, and the cell adhesion molecule (CAM) L1 or NILE, as important gene products that are induced by neurotrophins including NGF and BDNF during neural differentiation and CNS/PNS development. Cultured neurons, neural and endocrine cell lines, hippocampal slices, and mouse models are all utilized to study effects of these proteins on synaptic plasticity, neurogenesis, axonal outgrowth, and axonal pathfinding. We are currently determining the signaling pathways, networks, and functional roles that these neurotrophin-regulated molecules play in clinically relevant diseases, including in major depressive disorder, neuropathic pain, obesity, and Alzheimer's disease.
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