Stephen Salton, MD, PhD
- PROFESSOR | Neuroscience
- PROFESSOR | Geriatrics and Palliative Medicine
Research Topics:
Adipose, Aging, Apoptosis/Cell Death, Axon Guidance, Brain, Cell Adhesion, Chromogranins and Secretogranins, Cognitive Neuroscience, Cytoskeleton, Depression, Diabetes, Growth Cone, Growth Factors and Receptors, Hormones, Memory, Neuropeptides, Neurotrophins, Obesity, Protein Phosphatases, Protein Trafficking & Sorting, Signal Transduction, Synapses
Research in the Salton lab is focused on understanding the mechanisms by which neurotrophic growth factors, including nerve growth factor (NGF) and brain-derived neurotrophic factor (BDNF), regulate nervous system development, adult function, and the response to injury and neurodegenerative disease.
Multi-Disciplinary Training Area
Neuroscience [NEU]Education
BA, University of Pennsylvania
Fellowship, Columbia Presbyterian and Mount Sinai School of Medicine
Internship and Residency, Bellevue and NYU School of Medicine
MD, New York University
PhD, New York University
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2008
NARSAD van Ameringen Investigator -
2006
NARSAD Independent Investigator -
1994
Irma T. Hirschl Career Scientist -
1991
Pew Scholar in the Biomedical Sciences -
1989
Pfizer Scholar -
1986
Pfizer Postdoctoral Fellow
Research
Specific Clinical/Research Interests: Molecular Neuroscience; Neurotrophin Signaling; Neuropeptides; Neural Cell Adhesion Molecules; Obesity; Diabetes; Depression; Major Depressive Disorder; Alzheimer's Disease.
Summary of Research Studies: Our research is focused on understanding the mechanisms by which neurotrophic growth factors, including nerve growth factor (NGF) and brain-derived neurotrophic factor (BDNF), regulate nervous system development and function. BDNF and NGF have been implicated in the pathophysiology of neurodegenerative disease, neuropsychiatric illness, CNS injury, and obesity. The contributions made by specific neurotrophin-regulated gene products to depression, memory, and energy balance, are being being examined using novel knockout, transgenic, and knockin mouse models. The lab has identified VGF, a secreted neuronal and neuroendocrine peptide precursor, and the cell adhesion molecule (CAM) L1 or NILE, as important gene products that are induced by neurotrophins including NGF and BDNF during neural differentiation and CNS/PNS development. Cultured neurons, neural and endocrine cell lines, hippocampal slices, and mouse models are all utilized to study effects of these proteins on synaptic plasticity, neurogenesis, axonal outgrowth, and axonal pathfinding. We are currently determining the signaling pathways, networks, and functional roles that these neurotrophin-regulated molecules play in clinically relevant diseases, including in major depressive disorder, neuropathic pain, obesity, and Alzheimer's disease.
Visit Dr. Stephen Salton's Lab for more information.
Physicians and scientists on the faculty of the Icahn School of Medicine at Mount Sinai often interact with pharmaceutical, device and biotechnology companies to improve patient care, develop new therapies and achieve scientific breakthroughs. In order to promote an ethical and transparent environment for conducting research, providing clinical care and teaching, Mount Sinai requires that salaried faculty inform the School of their relationships with such companies.
Dr. Salton did not report having any of the following types of financial relationships with industry during 2022 and/or 2023: consulting, scientific advisory board, industry-sponsored lectures, service on Board of Directors, participation on industry-sponsored committees, equity ownership valued at greater than 5% of a publicly traded company or any value in a privately held company. Please note that this information may differ from information posted on corporate sites due to timing or classification differences.
Mount Sinai's faculty policies relating to faculty collaboration with industry are posted on our website. Patients may wish to ask their physician about the activities they perform for companies.