Talia H Swartz, MD, PhD
- ASSOCIATE DEAN FOR MD/PHD EDUCATION
- ASSOCIATE PROFESSOR | Medicine, Infectious Diseases
- ASSOCIATE PROFESSOR | Medical Education
Research Topics:Cellular Immunity, Cytokines, HIV/AIDS, Imaging, Immunology, Infectious Disease, Inflammation, Membrane Proteins/Channels, Membranes, Microbiology, Microglia, Mucosal Immunology, Opioid/Cannabinoid Receptors, T Cells, Translational Research, Transporters, Virulence Genes, Viruses and Virology
Talia Swartz, MD, PhD, is Associate Professor in the Department of Medicine, Division of Infectious Diseases and Medical Education. She is board certified in Internal Medicine and Infectious Disease. Her clinical training is in Infectious Diseases with a specific interest in care for people with HIV and her basic science interest is in the biology that underlies chronic HIV infection and severe COVID-19. Her NIH-funded research laboratory investigates the signaling that mediates inflammatory signaling in response to infection and aims to develop novel treatment paradigms that reduce the morbidity and mortality of HIV-1 disease and COVID-19.
Dr. Swartz is Co-Director of the MD/PhD Program and Associate Dean for MD/PhD Education. She has been deeply committed to supporting the training of physician scientists through recruitment and support of diverse trainees who are navigating dual training in medicine and biomedical science. She is involved in innovative curricular development, outreach, and student support, both at the Icahn School of Medicine at Mount Sinai and through the AAMC GREAT Group MD/PhD Section Communications Committee where she has been developing resources to make physician scientist training available to a more diverse group of future trainees.
Follow on Twitter @taliaswartz
- HIV and AIDS
Multi-Disciplinary Training AreasGenetics and Genomic Sciences [GGS], Immunology [IMM], Microbiology [MIC], Neuroscience [NEU], Pharmacology and Therapeutics Discovery [PTD]
PhD, Mount Sinai School of Medicine
MD, Mount Sinai School of Medicine
Residency, Internal Medicine, The Mount Sinai Hospital
Fellowship, Infectious Diseases, The Mount Sinai Hospital
Junior Faculty Research Award
Distinguished Scholar Award
Excellence in Teaching Award
Edward J. Ronan Award
Translational Collaborative Research Development Award
Junior Faculty Award
Alpha Omega Alpha Postgraduate Research Award
Alpha Omega Alpha, Resident/Fellow Member
House Staff Excellence in Teaching Award
Modeling HIV microglia-association infection and inflammation in a chimeric mouse brain
To better understand how HIV affects the brain in the era of combination antiretroviral therapy, and to improve current treatment options, we will study the cell susceptible to HIV infection human microglia, in the mouse brain. This includes novel experimental therapies of antiretrovirals combined with cannabinoid receptor-specific drugs that could lower the extent of inflammation and infection in the brain.
Elucidating the mechanisms of cannabinoids on HIV-1 infection and inflammasome activation
Recent evidence has suggested an important role of the NLRP3 inflammasome as a driver of inflammation. Cannabinoids have been shown to reduce inflammasome activity. What remains unknown is the effect that cannabinoids have on HIV-stimulated NLRP3 inflammasome activity. Our goal is to elucidate the role of cannabinoids in modulating HIV-inflammasome signaling in lymphoid tissue.
Building a diverse and robust physician scientist pipeline
The lack of diversity in gender, race/ethnicity, of the physician scientist pipeline threatens the ability of the biomedical workforce to serve the needs of our patients. There is a critical need for us to expand the diversity of the physician scientist workforce through recruitment, admissions, and retention efforts.
Dissecting the mechanisms of HIV-1 infection and inflammatory signaling in human lymphoid tissue
Purinergic receptors and downstream inflammasome signaling mediators are important contributors to HIV-1 entry and in driving inflammation. Preliminary data indicate that inhibitors of purinergic signaling reduce both HIV-1 infection and inflammatory cytokine signaling. Our goal is to elucidate the role of HIV-1 in mediating inflammatory signaling in lymphoid tissue.
Functional Assessment of anti-Env and inflammatory markers during delayed FTR-mediated virologic control
The goal of this study is to test the role of enhanced antibody responses in the delayed virologic control observed in Fostemsavir treated patients who have multidrug resistant HIV.