Tingting Jiang, PhD
img_Tingting Jiang
ASSISTANT PROFESSOR | Oncological Sciences
ASSISTANT PROFESSOR | Genetics and Genomic Sciences
Research Topics
Biomedical Sciences, Cancer, Cancer Genetics, Cell Biology, DNA Recombination, DNA Repair, Gene Expressions, Gene Therapy, Gene editing, Genetics, Genomics, Liver, Lung, Mitochondria, Molecular Biology
Multi-Disciplinary Training Area
Cancer Biology [CAB], Genetics and Genomic Sciences [GGS]
Genetic diseases; Genome editing; Gene therapy; Cancer drug resistance
Our lab focuses on developing advanced genome editing tools to accurately correct the causative genetic mutations or reprogram the defective DNA sequences to restore the functional domains. Moreover, taking advantage of versatile CRISPR tools, we will introduce disease-associated mutations in vitro or in vivo, modeling the disease pathogenesis pathways driven by these mutations, to facilitate the potential therapeutic targets discovery for treating complex genetic diseases, such as cancers. Further, utilizing those clinically-relevant in vivo delivery methods (e.g. AAV and nanoparticles), we will evolve our newly-engineered editing tools into gene therapy strategies to treat different mouse models. In all, by rewriting the defective genes, we will explore next-generation gene therapies for those untreatable human genetic diseases. Postdoctoral and graduate projects are available involving:(1) Develop next generation Cystic Fibrosis gene therapy; (2) Investigating mutations within the Extrachromosomal DNA and relevant genetic diseases; (3)Modulate drug resistance in liver cancers by targeting the driving mutations.

BSc, Nanjing University

PhD, National University of Singapore

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Dr. Jiang has not yet completed reporting of Industry relationships.

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