Tristan Shuman, PhD
- ASSISTANT PROFESSOR | Neuroscience
Research Topics:Autism, Epilepsy, Extracellular Unit Recording, Memory, Stem Cells, Transplantation
Tristan Shuman is an Assistant Professor of Neuroscience at the Icahn School of Medicine at Mount Sinai. His research focuses on how epilepsy leads to cognitive deficits and how these deficits can be rescued using interneuron transplantation in rodent models. His lab uses in vivo calcium imaging with miniature microscopes as well as electrophysiology to investigate the precise network alterations that produce seizures and cognitive deficits in epileptic mice. Dr Shuman obtained his PhD in Experimental Psychology from University of California, San Diego, where he examined how addiction-related memory ensembles contributed to cocaine drug seeking. Prior to joining the faculty at Mount Sinai, Dr Shuman was a postdoctoral fellow at the University of California, Los Angeles where he examined network alterations in epileptic mice.
PhD, University of California, San Diego
University of California, Los Angeles
AES Young Investigator Award
AES Grass Young Investigator Award
Epilepsy Foundation Postdoctoral Fellowship
Cognitive Deficits Associated with Temporal Lobe Epilepsy
Epilepsy is a debilitating disorder that affects over 3 million Americans, with 30% of patients unresponsive to anti-epileptic drugs and often resorting to large resections of the brain. Therefore, it is critical to develop new therapeutic interventions to suppress seizures and cognitive deficits in epilepsy. My lab uses state of the art recording and manipulation techniques to examine how abnormal circuit processing leads to seizures and cognitive deficits in epilepsy and to understand how seizures and cognitive deficits can be suppressed with novel interventions. We use in vivo calcium imaging with miniature microscopes as well as in vivo electrophysiology with silicon probes to examine how the epileptic brain is altered in mice.
Mechanisms of seizure and cognitive rescue using interneuron precursor transplantation
Stem cell transplantations offer a unique opportunity to treat the underlying cause of epilepsy by replacing the interneurons lost during epileptogenesis. Transplantation of embryonic interneuron precursors from the medial ganglionic eminence (MGE) into the hippocampus of epileptic mice dramatically reduces seizures and rescues performance on the Morris water maze spatial memory task. These transplanted interneurons integrate and form mature, functional connections, but there is significant debate about how they control seizures and cognitive deficits. My lab investigates the mechanisms of seizure and cognitive rescue by examining how transplanted interneurons reshape hippocampal circuits using both in vivo electrophysiology and calcium imaging.
Open source miniature microscopes
Miniscope.org is an online open-source platform for developing and using miniature microscopes primarily used for calcium imaging in small rodents. As a primary developer and contributor to this effort, my lab is continuing to develop new innovations of this technology and sharing them with the neuroscience community.
Shuman T, Amendolara B, Golshani P. Theta Rhythmopathy as a Cause of Cognitive Disability in TLE. Epilepsy currents; 17(2).
Cai DJ, Aharoni D, Shuman T, Shobe J, Biane J, Song W, Wei B, Veshkini M, La-Vu M, Lou J, Flores SE, Kim I, Sano Y, Zhou M, Baumgaertel K, Lavi A, Kamata M, Tuszynski M, Mayford M, Golshani P, Silva AJ. A shared neural ensemble links distinct contextual memories encoded close in time. Nature 2016 06; 534(7605).
Cowansage KK, Shuman T, Dillingham BC, Chang A, Golshani P, Mayford M. Direct reactivation of a coherent neocortical memory of context. Neuron 2014 Oct; 84(2).
Sano Y, Shobe JL, Zhou M, Huang S, Shuman T, Cai DJ, Golshani P, Kamata M, Silva AJ. CREB regulates memory allocation in the insular cortex. Current biology : CB 2014 Dec; 24(23).
Wood S, Sage JR, Shuman T, Anagnostaras SG. Psychostimulants and cognition: a continuum of behavioral and cognitive activation. Pharmacological reviews 2014; 66(1).
Shuman T, Cai DJ, Sage JR, Anagnostaras SG. Interactions between modafinil and cocaine during the induction of conditioned place preference and locomotor sensitization in mice: implications for addiction. Behavioural brain research 2012 Dec; 235(2).
Mednick SC, Cai DJ, Shuman T, Anagnostaras S, Wixted JT. An opportunistic theory of cellular and systems consolidation. Trends in neurosciences 2011 Oct; 34(10).
Anagnostaras SG, Wood SC, Shuman T, Cai DJ, Leduc AD, Zurn KR, Zurn JB, Sage JR, Herrera GM. Automated assessment of pavlovian conditioned freezing and shock reactivity in mice using the video freeze system. Frontiers in behavioral neuroscience 2010; 4.
Cai DJ, Shuman T, Harrison EM, Sage JR, Anagnostaras SG. Sleep deprivation and Pavlovian fear conditioning. Learning & memory (Cold Spring Harbor, N.Y.) 2009 Oct; 16(10).
Cai DJ, Shuman T, Gorman MR, Sage JR, Anagnostaras SG. Sleep selectively enhances hippocampus-dependent memory in mice. Behavioral neuroscience 2009 Aug; 123(4).
Shuman T, Wood SC, Anagnostaras SG. Modafinil and memory: effects of modafinil on Morris water maze learning and Pavlovian fear conditioning. Behavioral neuroscience 2009 Apr; 123(2).