Veronica Rodriguez-Bravo, PhD
- ASSISTANT PROFESSOR | Pathology
- ASSISTANT PROFESSOR | Oncological Sciences
Research Topics:Cancer, Cell Biology, Cell Cycle, Cell Division, Drug Resistance, Genetics, Mitosis, Molecular Biology
Multi-Disciplinary Training AreasCancer Biology [CAB], Genetics and Genomic Sciences [GGS]
BS, University of Barcelona (UB)
PhD, School of Medicine at University of Barcelona
Postdoctoral, Memorial Sloan Kettering Cancer Center (MSKCC)
Postdoctoral, University Medical Center Utrecht (UMC)
Postdoctoral Research Award
Nomination Blavatnik Regional Awards for Young Scientists
Extraordinary Doctorate Award
My research focuses on the study of genome integrity maintenance mechanisms and the relationship of defects with cancer. The laboratory is particularly interested in understanding mechanistically the roads leading to chromosomal instability and aneuploidy in human cells and deciphering the consequences for cancer initiation, progression and tumor cells’ therapeutic responses. To address this, we analyze cell cycle checkpoint responses and nuclear pore complex functionality in non-tumor and tumor cell models through a multidisciplinary approach that combines molecular biology, cell biology and genetics with cancer biology, computational analysis and patient tissue sample validation.
Vidal SJ, Rodriguez-Bravo V, Quinn SA, Rodriguez-Barrueco R, Lujambio A, Williams E, Sun X, de la Iglesia-Vicente J, Lee A, Readhead B, Chen X, Galsky M, Esteve B, Petrylak DP, Dudley JT, Rabadan R, Silva JM, Hoshida Y, Lowe SW, Cordon-Cardo C, Domingo-Domenech J. A targetable GATA2-IGF2 axis confers aggressiveness in lethal prostate cancer. Cancer cell 2015 Feb; 27(2).
Williams ES, Rodriquez-Bravo V, Chippada-Venkata U, De Ia Iglesia-Vicente J, Gong Y, Galsky M, Oh W, Cordon-Cardo C, Domingo-Domenech J. Generation of Prostate Cancer Patient Derived Xenograft Models from Circulating Tumor Cells. Journal of visualized experiments : JoVE 2015;(105).
Vidal SJ, Quinn SA, de la Iglesia-Vicente J, Bonal DM, Rodriguez-Bravo V, Firpo-Betancourt A, Cordon-Cardo C, Domingo-Domenech J. Isolation of cancer stem cells from human prostate cancer samples. Journal of visualized experiments : JoVE 2014;(85).
Rodriguez-Bravo V, Maciejowski J, Corona J, Buch HK, Collin P, Kanemaki MT, Shah JV, Jallepalli PV. Nuclear pores protect genome integrity by assembling a premitotic and Mad1-dependent anaphase inhibitor. Cell 2014 Feb; 156(5).
Domingo-Domenech J, Vidal SJ, Rodriguez-Bravo V, Castillo-Martin M, Quinn SA, Rodriguez-Barrueco R, Bonal DM, Charytonowicz E, Gladoun N, de la Iglesia-Vicente J, Petrylak DP, Benson MC, Silva JM, Cordon-Cardo C. Suppression of acquired docetaxel resistance in prostate cancer through depletion of notch- and hedgehog-dependent tumor-initiating cells. Cancer cell 2012 Sep; 22(3).
Vidal SJ, Rodriguez-Bravo V, Galsky M, Cordon-Cardo C, Domingo-Domenech J. Targeting cancer stem cells to suppress acquired chemotherapy resistance. Oncogene 2014 Sep; 33(36).
Burkard ME, Maciejowski J, Rodriguez-Bravo V, Repka M, Lowery DM, Clauser KR, Zhang C, Shokat KM, Carr SA, Yaffe MB, Jallepalli PV. Plk1 self-organization and priming phosphorylation of HsCYK-4 at the spindle midzone regulate the onset of division in human cells. PLoS biology 2009 May; 7(5).
Lindqvist A, Rodríguez-Bravo V, Medema RH. The decision to enter mitosis: feedback and redundancy in the mitotic entry network. The Journal of cell biology 2009 Apr; 185(2).
Rodríguez-Bravo V, Guaita-Esteruelas S, Salvador N, Bachs O, Agell N. Different S/M checkpoint responses of tumor and non tumor cell lines to DNA replication inhibition. Cancer research 2007 Dec; 67(24).
Rodríguez-Bravo V, Guaita-Esteruelas S, Florensa R, Bachs O, Agell N. Chk1- and claspin-dependent but ATR/ATM- and Rad17-independent DNA replication checkpoint response in HeLa cells. Cancer research 2006 Sep; 66(17).