William L Holden

William L Holden, PhD

  • ASSOCIATE PROFESSOR | Environmental Medicine & Public Health

William L. Holden, PhD, is an Associate Professor in the Department of Preventive Medicine and serves as Deputy Director of the World Trade Center Health Program Data Center at the Icahn School of Medicine at Mount Sinai. Dr. Holden is an epidemiologist with more than 25 years’ experience in both private and academic settings with a focus on pharmacoepidemiology and occupational epidemiology. Majors contributions in pharmacoepidemiology include developing the first quantitative models for benefit-risk analysis; devising and implementing novel risk management frameworks for both drugs and vaccines; contributing a chapter to the industry standard Council for International Organizations of Medical Sciences (CIOMS) publication on Signal Detection; and shifting the focus from ‘drug safety’ to ‘patient safety’. Contributions in occupational epidemiology include completing numerous analyses of hazardous working conditions whilst an employee of a trade union and as a consultant; developing a method of evaluating the work-relatedness of premature ischemic heart disease; developing exposure standards to foundry fumes for the UK government; and teaching occupational epidemiologic methods and biostatistics to physicians and other professionals. As Deputy Director of the Data Center since 2013, Dr. Holden leads a team of epidemiologists, biostatisticians, and data management specialists, managing and analyzing more than 90 million health-related data points for more than 30,000 WTC responders as part of a long term follow up study. With unparalleled capability and experience in study design, analysis, and data management, the Data Center under Dr. Holden’s leadership is expanding to support research and surveillance in other areas of occupational medicine. Dr. Holden’s current research is focused on further developing benefit-risk analytic methods; incorporating critical thinking principles into epidemiologic studies; the application of Bayesian analytics to occupational health issues; and developing risk communication guidelines as necessary values in health care research. He holds a PhD, MS, and MPhil in epidemiology from Yale University as well as a MPH in epidemiology and a BA from Columbia University.


BA, Columbia University

MPH, Columbia University

MPhil, Yale University

MS, Yale University

PhD, Yale University