Xiaoting Wu, PhD
- ASSISTANT PROFESSOR | Neuroscience
Research Topics:Autism, Cognitive Neuroscience, Electrophysiology, Hippocampus, Memory, Neurobiology, Neuromodulation, Neuropeptides, Neuroscience, Neurotransmitters, Synapses, Synaptic Plasticity, Systems Neuroscience
Dr. Xiaoting Wu is an Assistant Professor in the Department of Neuroscience at the Icahn School of Medicine at Mount Sinai. Her research focuses on the neural basis of social cognition and the pathogenesis of its deficits in neuropsychiatric disorders. She obtained her PhD at the University of Cambridge and then completed a postdoctoral fellowship at Stanford University, where she investigated the molecular and circuit mechanisms underlying social memory.
Wu Lab website: https://labs.neuroscience.mssm.edu/project/wu-lab/
Multi-Disciplinary Training AreaNeuroscience [NEU]
PhD, University of Cambridge
Postdoctoral Fellowship, Stanford University
Trainee Professional Development Award
K99/R00 Pathway to Independence Award
DFG Postdoctoral Research Fellowship
FES Pre-doctoral Fellowship
Erasmus Exchange Scholarship
The Wu laboratory is focused on understanding the neurobiology of social cognition. We live in a social environment and the ability to distinguish various individuals, form memories of social encounters and make appropriate decisions is pivotal to our lives. How do neural circuitries and synaptic plasticity mediate social cognitive processes? Our lab uses multi-disciplinary approaches across molecular, synaptic, and behavioral scales to investigate this question. We employ techniques such as optogenetics, fiber photometry, electrophysiology, and single cell transcriptomics to uncover the mechanisms underlying social cognition.
Wu X, Morishita W, Beier KT, Heifets BD, Malenka RC. 5-HT modulation of a medial septal circuit tunes social memory stability. Nature 2021 11; 599(7883).
Walsh JJ, Christoffel DJ, Wu X, Pomrenze MB, Malenka RC. Dissecting neural mechanisms of prosocial behaviors. Current opinion in neurobiology 2021 06; 68.
Wu X, Morishita WK, Riley AM, Hale WD, Südhof TC, Malenka RC. Neuroligin-1 Signaling Controls LTP and NMDA Receptors by Distinct Molecular Pathways. Neuron 2019 05; 102(3).
Pavel M, Imarisio S, Menzies FM, Jimenez-Sanchez M, Siddiqi FH, Wu X, Renna M, O'Kane CJ, Crowther DC, Rubinsztein DC. CCT complex restricts neuropathogenic protein aggregation via autophagy. Nature communications 2016 12; 7.
Wu X, Fleming A, Ricketts T, Pavel M, Virgin H, Menzies FM, Rubinsztein DC. Autophagy regulates Notch degradation and modulates stem cell development and neurogenesis. Nature communications 2016 Feb; 7.
Wu X, Won H, Rubinsztein DC. Autophagy and mammalian development. Biochemical Society transactions 2013 Dec; 41(6).