Zhenyu Yue

Zhenyu Yue, PhD

  • PROFESSOR | Neurology
  • PROFESSOR | Neuroscience

Research Topics:

Alzheimer's Disease, Apoptosis/Cell Death, Autophagy, Axonal Growth and Degeneration, Human Genetics and Genetic Disorders, Knockout Mice, Lysosomes/endosome, Molecular Biology, Neuro-degeneration/protection, Parkinson's Disease, Protein Degradation, Protein Kinases, Protein Trafficking & Sorting, Schizophrenia, Synapses

Dr. Zhenyu Yue is the Aidekman Research Professor at Department of Neurology and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai. He is the Director of Basic Research of Movement Disorders and the Director for NINDS/NIH Exploratory Program for Parkinson’s disease Research. Dr. Yue’s laboratory investigates cellular and molecular mechanisms for neurological disorders including Parkinson’s disease (PD), Alzheimer’s diseases (AD), Huntington's disease (HD), and schizophrenia/bipolar disorder. His laboratory employs multi-disciplinary approaches, such as systems biology (single-cell RNAseq, proteomics, spatial transcriptomics), molecular biology, protein/lipid biochemistry, optical imaging, immunohistochemistry, iPSC-induced neurons/glia, primary mouse neuron/glia cultures and genetic mouse models. Dr. Yue’s lab is currently focused on microglial functions and senescence in age-related neurodegenerative diseases, gut-brain axis in PD progression and transmission, dopamine neuron vulnerability/resilience in PD/Lew body dementia (LBD), cellular and molecular basis for selective autophagy underlying proteinopathies, synaptic trafficking and PKA-mediated neuronal activity regulation for synaptopathies, including psychiatric diseases. His lab is interested in translational research including biomarker and therapeutic development.  Dr. Yue has contributed more than 150 SCI publications including original research articles and reviews/commentaries.

The Yue Laboratory

Multi-Disciplinary Training Areas

Neuroscience [NEU], Pharmacology and Therapeutics Discovery [PTD]