Zhenyu Yue, PhD
- PROFESSOR | Neurology
- PROFESSOR | Neuroscience
Research Topics:Apoptosis/Cell Death, Autophagy, Axonal Growth and Degeneration, Human Genetics and Genetic Disorders, Knockout Mice, Lysosomes/endosome, Molecular Biology, Neuro-degeneration/protection, Parkinson's Disease, Protein Degradation, Protein Kinases, Protein Trafficking & Sorting, Synapses
Zhenyu Yue, PhD, is a Professor of Neurology and Neuroscience and Director of Basic and Translational Research of Movement Disorders.
Multi-Disciplinary Training AreasNeuroscience [NEU], Pharmacology and Therapeutics Discovery [PTD]
- Autophagy-lysosome pathway as neuroprotection mechanism in the maintenance of axon and dendrite homeostasis and the clearance of protein aggregates, including polyQ expansion proteins (such as Huntington), tau and alpha-synuclein.
- The regulation of autophagy and endocytosis in neurons and neurodegeneration by PI3K-III lipid kinase complex proteins, including the modulators/adaptors: Beclin 1, Atg14L, URRAG, Rubicon and NRBF2; development of small compounds as modulators for PI3K-III activity and neuronal autophagy.
- Protein/lipid kinase and phosphatase in regulating synaptic vesicle trafficking and dysfunction in neurotransmission underlying Parkinson’s disease.
- The contribution of peripheral immune system and CNS glial cells to the neuro-inflammation path-ways underlying neurodegeneration mechanism in Parkinson’s disease and other human disorders.
- The molecular, cellular, and structural dissection of LRRK2 kinase in familial Parkinson’s disease; kinase inhibitor development as therapeutics to treat Parkinson’s disease.
- Genetic animal model development for human movement disorders and neurodegenerative diseases.
Molecular, Cellular, Behavioral Biology, and Translational Research in Neurodegeneration
The long-term goal of Yue Laboratory is to understand the molecular and cellular mechanisms of neu-rodegeneration that causes human neurological disorders such as Parkinson’s, Huntington’s and Alz-heimer’s diseases. The laboratory’s mission is to translate their knowledge from basic research to the development of molecular diagnostics and therapeutics for neurological disorders. Yue Laboratory’s primary research interests encompass molecular and cellular pathways for autophagy-lysosome deg-radation, synaptic vesicle trafficking, neuroinflammation, and protein/lipid kinase signaling in neuro-pathogenesis.