About The Mindich Child Health and Development Institute
The Mindich Child Health and Development Institute (MCHDI) is a translational research enterprise with the mission of advancing knowledge and therapies for diseases affecting infants, children, and adolescents. Led by Bruce D. Gelb, MD, the MCHDI provides an intellectually rich and supportive environment for fostering collaborative scientific investigation and Mount Sinai’s “bench to bedside” philosophy, as well as training the next generation of scientific leaders in pediatric medicine.
Physician-scientists and scientists at the MCHDI work in a multidisciplinary manner with researchers and physicians in various departments and institutes at Mount Sinai. Together, we strive toward the objectives of developing robust paradigms for understanding the effects of genetics and environment on the health of infants, children and adolescents, and personalizing pediatric medicine through genetics and genomics.
Unparalleled Expertise at Mount Sinai
Mount Sinai carries a longstanding tradition of clinical and research innovation and accomplishments. The MCHDI builds upon existing strengths which span several departments, institutes, and research programs, in order to leverage resources and accelerate achievement. Specifically, Mount Sinai created one of the nation's first Department of Pediatrics that garners top 20 funding from the National Institutes of Health (NIH) and other extramural granting agencies.
Strategic Partnerships for Advancing Child Health
The MCHDI collaborates extensively with various institutional partners. We work closely with Mount Sinai's Departments of Pediatrics, Genetics and Genomics Sciences, Preventative Medicine, Psychiatry, Developmental and Regenerative Biology, as well as other hospitals and organizations nationwide. Additionally, we coordinate research efforts with other translational institutes at Mount Sinai, including the Institute for Genomics and Multiscale Biology, Charles R. Bronfman Institute for Personalized Medicine, Black Family Stem Cell Institute, the Friedman Brain Institute, as well as the Immunology and Metabolism Institutes. We also partner with key clinical and research centers: the Jaffe Food Allergy Institute, the Seaver Autism Center for Research and Treatment, the Children's Heart Center, the Hall Family Center for Pediatric Endocrinology and Diabetes, and the Adolescent Health Center.
Recent technologic advances, particularly for DNA sequencing, have brought clinicians and scientists to a breathtaking juncture, as it is now possible to sequence all of the protein-encoding portions of the human genome in a matter of days. Significant genomic strides such as this bring about remarkable translational research possibilities. Leveraging genetics and genomics data and the surrounding diverse population in New York City, the 's research initiatives focus on four major areas of investigation:
- Asthma and allergy
- Cardiovascular disease
- Neurodevelopment disorders
- Obesity and Diabetes
Through various explorations of disease pathogenesis, the MCHDI aims to maximize the use of genetic information to improve the health of children. We are strongly committed to expanding the scientific infrastructure for genomic technology and developing new personalizing pediatric therapies, not only to maximize efficacy and reduce side effects, but also to improve diagnostic accuracy and outcome predictions.