GenomeWeb - Human-Specific Histone Methylation Signatures Found in Prefrontal Cortex

 – November 21, 2012  –– 

There are hundreds of genomic regions that are uniquely regulated in the human brain as compared to other primates, an international team of researchers reported in PLOS Biology this week. Dr. Schahram Akbarian from Mount Sinai School of Medicine homed in on the prefrontal cortex of the brain as it is involved in complex cognitive functions, and changes to its transcriptome are thought to be behind human cognitive abilities as well as disorders. "Much about human biology and disease cannot be deduced by simply sequencing the genome," said Dr. Akbarian. "Mapping the epigenome of neurons and other cells will help us to better understand the inner workings of our brain, and where we are coming from."
- Dr. Schahram Akbarian, Professor, Psychiatry, Neuroscience, Mount Sinai School of Medicine
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