MedPage Today - Lab Notes: BP Drugs Cut Brain Amyloid

 – June 7, 2013  –– 

Certain antihypertensives have the unintended side effect of reducing the accumulation of beta-amyloid in the brains of mice with Alzheimer's disease, researchers found. Giulio Maria Pasinetti, MD, PhD, of the Icahn School of Medicine at Mount Sinai, and colleagues screened 1,600 FDA-approved drugs to look for any that might have activity either inhibiting or promoting the formation of beta-amyloid. They identified 184 drugs that reduced levels of the protein by more than thirty percent including 13 cardiovascular drugs.
-Dr. Giulio M. Pasinetti, Professor, Neurology, Psychiatry, Geriatrics and Palliative Medicine, Neuroscience, Icahn School of Medicine at Mount Sinai
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