The Genetic Heroes That Could Cure the Sick

 – July 1, 2014  –– 

One person in 20,000 is predicted to be a ‘genetic hero’—someone who should have a disease, but due to rare mutations or lifestyle, doesn’t. Now, the Resilience Project is making it easier than ever to find them, and hopefully find treatment for the sick in the process. Scientists Stephen Friend of Sage Biosciences and Eric Schadt, PhD, Director of the Institute for Genomics and Multiscale Biology, Chairman of the Department of Genetics and Genomics Sciences, and the Jean C. and James W. Crystal Professor of Genomics at the Icahn School of Medicine at Mount Sinai, and Co-Investigator of the Resilience Project, described their new endeavor called the Resilience Project last month in the journal Science, which seeks to find individuals carrying genes that should normally lead to severe disease but have no signs of illness. “The human genetics community is focused on disease. We want to turn it around and identify people who should be sick but aren’t,” said Dr. Schadt. “However they manage to resist disease could yield new treatments.”

-Dr. Eric Schadt, Director of the Institute for Genomics and Multiscale Biology, Chairman of the Department of Genetics and Genomics Sciences and the Jean C. and James W. Crystal Professor of Genomics, Icahn School of Medicine at Mount Sinai

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