"Vitamin C Blocks Leukemia Progression In Mice" - Aggie Mika
Researchers have halted the progression of leukemia in mice by restoring the enzyme TET2 in hematopoietic stem cells, either by reestablishing its gene expression in transgenic mice or by promoting the protein’s function with high doses of vitamin C. In a small experiment, vitamin C injections also suppressed leukemia progression in immunocompromised mice transplanted with hematopoietic stem cells from two leukemia patients. “If these findings withstand clinical testing, the impact for patients with blood cancers could be significant,” said Eirini Papapetrou, MD, PhD, associate professor of oncological sciences, medicine, hematology, and medical oncology, at the Icahn School of Medicine at Mount Sinai. “These patients have currently limited therapeutic options, particularly the more elderly patients, who cannot tolerate highly toxic treatment, like high-dose chemotherapy or bone marrow transplantation.”
- Eirini Papapetrou, MD, PhD, Associate Professor, Oncological Sciences, Medicine, Hematology, and Medical Oncology, Icahn School of Medicine at Mount Sinai
Scientists Create Most Powerful, Accurate Tool Yet to Research Deadliest Blood Cancer
Apr 18, 2023 View All Press ReleasesResearchers Identify New Drug Target for Blood Cancer, Potentially Solid Tumors
Oct 07, 2021 View All Press ReleasesScientists Create Novel Model That Shows Progression From Normal Blood Cells to Leukemia
Feb 16, 2017 View All Press Releases