AREN0534: Treatment for Patients with Bilateral, Multicentric, or Bilaterally- Predisposed Unilateral Wilms Tumor

ID Number 80-0066-00056

Principal Investigator(s)
Birte Wistinghausen

Department(s) or Division(s)
Pediatrics

Description

The goals of this study are:

  • For subjects with DHPLN:
    • to find out if giving chemotherapy before surgery will save as much normal kidney tissue as possible and prevent a Wilms tumor from developing. This is an experimental treatment.
    • To collect information on the natural history of this rare disorder and to determine if response to treatment can be monitored with repeated scans such as CTs and MRIs.
    • For all subjects, to find out if the change in chemotherapy drugs that will be given after surgery should be based on how the tumor has changed or how the tumor cells look or have changed (by looking at them under a microscope) after receiving 2 cycles of chemotherapy before the surgery.
  • For subjects with unilateral Wilms tumor:
    • For subjects with unilateral Wilms tumor with other risk factors (abnormal cells in the other kidney or predisposing syndromes) to find out if giving chemotherapy before surgery will shrink the tumor so when surgery is done a portion of the normal kidney can be saved. This is an experimental treatment.
    • For subjects who have very aggressive tumor cells (anaplasia) to see if using a five-drug chemotherapy drug regimen will be more effective at killing the tumor cells and improving patient survival. This is an experimental treatment.
    • For all subjects, to find out if we should change the chemotherapy drugs that will be given after surgery, based on how the tumor cells have changed or look (by looking at them under a microscope) and how the images of the tumor have changed after receiving 2 cycles of chemotherapy before surgery.
  • For subjects with bilateral Wilms tumor:
    • To find out if giving three drugs instead of two will help get rid of the tumor cells while saving the largest amount of normal kidney tissue. This is an experimental treatment.
    • To improve survival for patients with Wilms tumor.
    • For all subjects, to find out if the chemotherapy drugs that will be given after surgery should be based on how the tumor has changed or how the tumor cells look or have changed (by looking at them under a microscope) after receiving 2 cycles of chemotherapy before the surgery.
    • Subjects who have anaplastic Wilms tumor, an aggressive form of Wilms tumor, with a stage that is higher than Stage I, will receive a five-drug chemotherapy drug regimen instead of the standard 4-drug chemotherapy regimen. This is an experimental treatment.


Contact Information
Venesha White
(212) 241-3744


Recruiting Patients: Yes