The Epidemiology of Bleeding and Clotting in Patients Undergoing Heart Transplantation, Coronary Artery Bypass Graft Surgery,

ID Number 08-1093-00002

Principal Investigator(s)
Annetine C. Gelijns

Department(s) or Division(s)
Health Evidence and Policy

Description

The purpose of this prospective cohort study is to characterize the specific sites and timing of clotting cascade activation triggered by CPB (cardiopulmonary bypass) and VAD (Ventricular Assist Device) therapy in end-stage heart failure patients. To control for the effect of heart failure on clotting cascade activation, subjects undergoing CPB for heart transplantation were included in the original cohort. Preliminary data from the CPB/transplant group revealed that the activation of the intrinsic pathway was unexpectedly sustained. As such, the control group cohort is being modified in this revision of the protocol (Rev 6) to include patients with ventricular dysfunction who undergo CPB for a clinically indicated coronary artery bypass grafting (CABG) procedure.



Contact Information
Julie Giacalone
(212) 659-9618
julie.giacalone@mountsinai.org


Recruiting Patients: No