Ronald M. Loeb Center for Alzheimer’s Disease

Building a Tomorrow Without Alzheimer's Disease

Alzheimer's disease represents a growing public health crisis as our population ages, affecting millions with no effective treatment. At The Ronald M. Loeb Center for Alzheimer's Disease at the Icahn School of Medicine at Mount Sinai, we address this challenge through comprehensive research that spans from basic molecular mechanisms to innovative clinical interventions. Our strength lies in our collaborative, multidisciplinary community that unites experts across diverse departments and institutes, creating an environment where groundbreaking discoveries can flourish.

Alison M. Goate, DPhil, is Director, The Ronald M. Loeb Center for Alzheimer's Disease; the Jean C. and James W. Crystal Professor of Genomics and Chair, Department of Genetics and Genomic Sciences; and Professor, Neuroscience and Neurology, Icahn School of Medicine at Mount Sinai. She is best known for identifying the first gene mutation linked to inherited Alzheimer's disease and has developed novel methods that have accelerated research across the field. Her pioneering work in gene discovery and disease modeling has led to significant breakthroughs, including finding rare mutations that cause Alzheimer’s disease, frontotemporal dementia and amyotrophic lateral sclerosis, and risk genes expressed in immune cells of the brain that influence risk of developing late-onset Alzheimer's disease.

Founded through a generous gift from Mount Sinai trustees Daniel Loeb and Margaret Munzer Loeb, The Ronald M. Loeb Center for Alzheimer's Disease has grown into a research powerhouse. Our investigators have uncovered critical genetic risk factors across diverse populations, identified key molecular drivers that influence disease pathology, and developed machine learning models that predict outcomes with remarkable accuracy. By connecting laboratory discoveries directly to patient interventions, the Center transforms how we diagnose, prevent, and treat Alzheimer's disease.

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MEET THE DIRECTOR

Alison M Goate, DPhil

PROFESSOR & CHAIR | Genetics and Genomic Sciences

PROFESSOR | Neuroscience

PROFESSOR | Neurology

Dr. Goate is a pioneering molecular geneticist who identified the first mutation to cause familial Alzheimer's disease and has transformed the field through her genetic discoveries.

Read the Message From the Director

AT A GLANCE