Midlife Vascular Risk Factors Tied to Brain Amyloid - Kristina Fiore
Having more vascular risk factors in middle age was associated with greater brain amyloid deposition in later life, researchers found. Sam Gandy, MD, PhD, director of the Center for Cognitive Health at The Mount Sinai Hospital, said the work dovetails nicely with two papers he and colleagues have published regarding vascular risk factors and dementia, although he's not certain that amyloid is requisite for dementia. "One-third of clinical Alzheimer's disease lacks amyloidosis despite clinical cognitive decline, hippocampal atrophy, and changes in [brain glucose metabolism]," Gandy told MedPage Today. "I think that what we are learning is that there are many pathways that converge on the clinical Alzheimer's phenotype, and not all involve the canonical amyloid-first pathway."
Samuel Gandy, MD, PhD, Professor, Neurology, Psychiatry, Icahn School of Medicine at Mount Sinai, Director, Mount Sinai Center for Cognitive Health, Associate Director, Mount Sinai Alzheimer's Disease Research Center, Director, NFL Neurological Care Program at The Mount Sinai Hospital