Parkinson's Disease and Other Movement Disorders

Movement disorders are a heterogeneous collection of neurologic syndromes that have in common abnormalities in an individual's control over their motor function. Prominent examples of movement disorders include: Parkinson's disease, atypical parkinsonism (including multiple systems atrophy, corticobasal ganglionic degeneration, and progressive supranuclear palsy), dystonia, essential tremor, Huntington's disease, tic disorders, and amyotropic lateral sclerosis (ALS, also known as Lou Gehrig's disease). Beyond offering world-class diagnosis and treatment for these illnesses, Mount Sinai scientists and physicians are conducting groundbreaking research into the causes of these illnesses aimed at developing more effective treatments.


Our faculty members are recognized leaders in research into the genetic basis of dystonia and Parkinson's disease. A major focus of their research is on mutations in the LRRK2 and GBA genes, as well as on identifying novel genes that confer disease risk.

Scientists involved: Laurie Ozelius, Rachel Saunders-Pullman, Coro Paisan-Ruiz

Disease Pathophysiology

Mount Sinai scientists are investigating the molecular and cellular basis of Parkinson's disease in animal models. Coordinated research with our genetics team is helping to understand how LRRK2 and GBA mutations lead to disease. The role of autophagy in disease pathogenesis is also being investigated.

Scientists involved: Zhenyu Yue, Michelle Ehrlich

Closely related research is investigating the relationship between brain changes and genetic factors in humans with spasmodic dysphonia, a form of focal dystonia.

Scientists involved: Kristina Simonyan

Clinical Trials

We have an extensive clinical trials program for movement disorders where we evaluate and recruit patients into novel clinical research protocols that have been developed to study the effectiveness of new treatments. Patients who participate in our clinical trials have access to the latest experimental evaluations and therapies, as well as ongoing clinical care.

Numerous clinical trials are underway within the Mount Sinai Health System on more effective treatments for a range of movement disorders, in particular, Parkinson disease, dystonia, essential tremor, and ALS.

Contact Us

Robert and John M. Bendheim Parkinson and Movement Disorders Center

Phone: 212-241-5607
Fax: 212-241-3656
Send e-mail

5 East 98th Street
Box 1138, First Floor
New York, NY 10029-6574

Schedule an Appointment

Center for Neuromodulation
Phone: 212-241-0050

1468 Madison Avenue
Annenberg Building
8th Floor, Room 40
New York, NY 10029

Mount Sinai Beth Israel Research
Phone: 888-228-1688

10 Union Square East
Suite 5H
New York, NY 10003