The Department of Pediatrics at the Icahn School of Medicine has a long and distinguished tradition of excellence in clinical, translational and basic research. Department research now addresses a wide range of problems relevant to our understanding, treatment and prevention of childhood disease. This research has been aided significantly by the recruitment of new faculty, resulting in approximately $3 million of new grant support from the National Institutes of Health and other sources.
Research efforts of particular note include studies focusing on:
- The pathogenesis of parainfluenza and herpes virus infections
- Molecular genetics of congenital heart disease
- Developmental biology of the liver and biliary tract
- Pathophysiology of cholestatic liver disease
- Mechanisms of electrolyte transport by the kidney
- Noninvasive treatment of congenital heart defects
- Immunopathogenic mechanisms of food hypersensitivity
- Regulation of the gene responsible for cystic fibrosis
- Development of novel treatment strategies for sickle cell anemia
- Pathophysiology of bone marrow failure syndrome
- Immune defense mechanisms of the neonatal intestine
- The use of tympanostomy tubes in children
- The effects of violence in the home
Research of global reputation includes studies focused on the molecular genetics of:
- Congenital heart disease
- Molecular physiology and regulation of ion transport in the developing and polycystic kidney
- Immune-pathogenic mechanisms and treatment of food allergy and asthma
- Treatment and natural history of disorders of steroid biosynthesis
- Epigenetic mechanisms underlying regulation of IGF-I expression
- Regulation of chromatin structure and function during gene transcription
The Department of Pediatrics is committed to basic science and clinical investigation in the pediatric subspecialties. Our faculty will continue to apply the tools of modern molecular and cellular biology to questions of development and physiology. Our department is dedicated to expanding its expertise in clinical epidemiology and outcomes research so that we may more objectively assess the quality and effectiveness of pediatric health care.
Child Health and Development Institute
The Child Health and Development Institute (CHDI) is a translational research enterprise with the mission of advancing knowledge and therapies for diseases that represent critical health problems for an ever-growing number of children in Mount Sinai’s community and beyond:
- Obesity and diabetes
- Congenital heart disease
- Neurodevelopmental disorders
CHDI provides an intellectually rich and supportive environment for fostering collaborative scientific investigation and Mount Sinai’s “bench to bedside” philosophy, as well as training the next generation of scientific leaders in pediatric medicine.
We continue to conduct groundbreaking research in a number of areas, including food allergy, kidney and liver diseases, endocrinology, and congenital heart defects. One significant measure of the success of this effort is the extramural (including that from the National Institutes of Health) research funding that has been awarded to our researchers, which now exceeds $20 million annually, placing us among the top pediatric departments nationwide and surpassing every other pediatric program in New York State. Receipt of this degree of support helps our physicians and scientists move one step closer to pioneering new breakthroughs and innovations that will enhance children’s lives.