Psychiatric and Neurological Genetics and Genomics
Mount Sinai has a long and rich history of contributions to genetics, psychiatry, and neurology. In 2011, new divisions focusing on genetics and genomics and neurodevelopmental disorders in psychiatry were established, as well as a new Institute for Genomics and Multiscale Biology. There has been rapid growth in The Friedman Brain Institute with the addition of many new faculty members from distinguished institutions, including the Institute of Psychiatry in London, Harvard Medical School, Stanford and University of California, San Diego (UCSD).
The landscape of human genetics has changed dramatically over the last ten years. It has been indelibly shaped by revolutions in genetic information and technology. The first fruits of the human genome project, the compendium of human DNA sequence, are now largely taken for granted. Extensive fine-scale maps have been made of human variation, both single nucleotide and structural, that provide the necessary genetic markers for genome-wide association studies. High-throughput methods for genotyping and so-called next generation sequencing machines are now available at reasonable costs. While human geneticists have had a long history of success identifying genes for single-gene disorders, the coupling of genetic information and technology has lead to an explosion of insights into complex multigenic disorders, like autism, schizophrenia and bipolar disorder, Parkinson's disease, and related movement disorders, and Alzheimer's disease. Scientists are making tremendous strides in understanding the genetics of psychiatric and neurological disorders, and Mount Sinai researchers are at the forefront of these studies across major illnesses.
Areas of Research
Research harnessing the complexity of data available through genetics, neuroimaging, and molecular studies by applying systems biology approaches is one of our new major areas of study at Mount Sinai. The other is the application of cutting-edge stem cell technologies to study neuron-like cells induced from a patient's skin cells and thereby study that person's illness.
Scientists involved: Schahram Akbarian, Katherine Burdick, Joseph Buxbaum, Joel Dudley, Gang Fang, Menachem Fromer, Sam Gandy, Laurie Ozelius, Dalila Pinto, Shaun Purcell, Panagiotis Roussos, Coro Paisan-Ruiz, Eric Schadt, Andrew Sharp, Pamela Sklar, Eli Stahl, Alison Goate
Icahn Medical Institute Floor 3 / Suite 3-31 Room L3-43
1425 Madison Avenue
New York, NY 10029