The work of the laboratory focuses on identifying and characterizing novel pathways in the kidney podocyte that are critical to the pathogenesis of glomerulosclerosis. In this way, we have identified increased expression of an adhesion protein, sidekick-1, in podocytes to be a crucial mediator of cellular dysfunction in several common human kidney diseases and we have begun to dissect the involved mechanisms.
We do this through cell culture, novel mouse models, and patient-based studies. Our ultimate goal is to identify novel disease pathways that can lead to new therapeutic targets. We have a number of ongoing projects ideal for renal fellows or post-docs who are interested in joining our group.
Lewis Kaufman, MD
1468 Madison Avenue
23rd Floor, Room 23-76 (Lab)
New York, NY 10029