The following research initiatives are coordinated by the department’s Office of Research:

For more specific information about the research initiatives taking place in the department, please see below.


Mentoring plan for junior faculty

The transition from trainee to independent investigator is extremely challenging.  After years of performing their research with total focus on the scientific process, junior faculty striving to become independent must suddenly start focusing on the business of running a successful and productive research program. Questions abound, and in the past most junior researchers were left to find their own way through this transition.

The Department of Medicine’s Office of Research has established a mentoring structure to provide guidance in setting up and managing a laboratory, setting career goals, developing grant applications and providing other essential tools for junior faculty to gain independence. The department also holds retreats to provide structured learning opportunities.

Global health research

Mount Sinai has a long tradition of reaching beyond its walls to local communities and those far beyond, Through our comprehensive global health program, the Department of Medicine is leading numerous research and educational initiatives on several continents. Working in close collaboration with Mount Sinai’s Institute for Global Health and Emerging Pathogens and our Global Health Center, our global health outreach is constantly expanding.

Resources for clinical trials and translational research

In 2004, in response to the growing complexities of clinical trials, the Mount Sinai Department of Medicine established its Clinical Trials Office to further the research efforts of investigators located within the department’s 11 subdivisions. In 2009, the office expanded its mission to include translational research and was renamed the Clinical and Translational Research Office (CTRO).

The CTRO provides regulatory, business, and other support to investigators conducting industry-sponsored studies, studies supported by Icahn School of Medicine (MSSM-sponsored), as well as NIH-sponsored research.  Services include:

  • Document preparation and submission to internal and external regulatory boards
  • Quality assurance in the areas of protocol feasibility, budget negotiation, centralized patient recruitment, and regulatory processes and monitoring
  • Training and education in regulatory affairs 

These services support interdivisional collaborations. The CTRO now manages more than 100 clinical trials within the Department of Medicine.

CTRO staff collaborate with sponsors and/or contract research organizations to prepare all pre-award documentation, including regulatory submissions and contract negotiations. The office also manages a wide range of regulatory procedures that arise post-award, such as protocol amendments and continuation applications. 

By working closely with teams of investigators and research coordinators, CTRO staff ensure that studies are managed efficiently and are fully compliant with all federal, local and institutional policies and guidelines. This administrative infrastructure allows investigators to obtain approval for studies in a timely manner and supports institutional compliance with regulatory requirements. Physician-scientists and their research teams are thereby able to focus the majority of their attentions on the scientific content of their research.

Grant writing resources

The Office of Research has developed templates that investigators may use to draft grant applications. These documents are only available internally on the Mount Sinai Network. Additional templates and tools are in development.

Cores – Proteomics, Bioinformatics, Statistics

The Department of Medicine at Icahn School of Medicine supports several research cores to provide services to Mount Sinai faculty. These include:


The Mount Sinai Biobank is a large collection of DNA and plasma samples that are stored in a way that protects patients' privacy while allowing research to be performed on de-identified clinical information from Mount Sinai's data warehouse system.

The goal of the Biobank is to acquire samples from 100,000 donors for future studies that will change the way medicine is practiced. Mount Sinai is one of only a handful of institutions nationwide that have established a biobank with such a large-scale goal.   

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