Neurosurgery Residency Facilities
On the twentieth floor in the Annenberg building at The Mount Sinai Medical Center there are three neurosurgical laboratories. A fourth laboratory is on the sixteenth floor of the East (Icahn) Building.
The Gene Therapy and Brain Tumor laboratory is under the direction of Isabelle M. Germano, MD, Professor of Neurosurgery, Neurology, and Oncological Sciences. It is located on the sixteenth floor of the Icahn Building, within the Department of Oncological Sciences. The research is currently funded by NIH/NCI and Industry. Its focus is translational research for brain tumors and the study of gene therapy for malignant brain tumors. In addition, a multi-disciplinary study is focused on evaluating stem cells for therapy of brain tumors. The lab is currently funded by an NIH grant. Luni Emdad, MBBS, PhD, Assistant Professor, works with Dr. Germano in this laboratory. Other laboratory members include Zulekha Abdul Qadeer, BS and Emanuela Binello, MD, PhD, ScD, Assistant Researchers.
Another laboratory is devoted to investigation of mechanisms underlying early brain and cerebrovascular injury using rodent models of subarachnoid hemorrhage and ischemia stroke. This research is directed by Fatima Sehba, PhD, a Research Associate Professor, and is funded by the NIH. Other laboratory members include Roka Abhishek, BS, and Weina Bi, MD, Research Coordinators.
A spinal cord injury laboratory, directed by Arthur Jenkins, MD, Assistant Professor of Neurosurgery, is working to develop treatments that will ultimately be used on paraplegic and quadriplegic spinal cord injured patients. The goal is to develop a model where the subjects are able to utilize their otherwise unresponsive limbs with the hope of making the patients fully independent. Working with Dr. Jenkins is Senior Scientist, Stanislaw Sobotka, PhD. Taking advantage of computer technology, surgical techniques and their understanding of the nervous system, they are using the latest in microelectrode technology, electronic implants, to electronically bypass the spinal cord lesion. This will essentially create an electronic nervous system and reconnect the nerves that are still functional (but not in communication with the brain) in the patients' extremities.
In addition, under a collaboration with the Brookhaven National Laboratories in Long Island, Dr. Jenkins and Dr. Sobotka are working with Dr. Avraham Dilmanian, PhD, to develop new treatments for acute or chronic spinal cord injury utilizing high energy microscopic beams of radiation to prevent the scar that forms within an area of spinal cord injury that normally acts as a barrier to regeneration of axons across the area of injury.
A laboratory directed by Don Weisz, PhD, Associate Professor of Neurosurgery, focuses on neurophysiological and behavioral studies of movement disorders and an NIH funded project involving protection of brain and spinal cord during circulatory arrest.
Two faculty work in other laboratories: Hongyan Zou, MD, PhD, is the PI (principal investigator) of the Laboratory of Axon Growth and Neuronal Regeneration where she and her team of researchers study the molecular mechanisms of axonal growth and neurogenesis with the goal of developing molecular treatments for neuronal and axonal regeneration. Roland Friedel, PhD, works with Professor Philippe Soriano in the Department of Developmental and Regenerative Biology. They are investigating the genetic causes of brain cancer with the goal of facilitating the development of targeted therapeutic strategies to treat gliomas.