Laboratories

Students in the Biophysics & Systems Pharmacology training program will spend a substantial amount of time working with our investigators and dedicated to research.

Lab NameDescription
Aggarwal Lab Uncovering how enzymes and transcriptional and translational regulators interact with nucleic acids to affect cellular development and disease outcome
Akar Laboratory Investigating arrhythmia mechanisms in structural heart disease at multiple levels of integration
Akbarian Laboratory Exploring organization and packaging of the genome inside the nuclei of human brain cells, including potential alterations in psychiatric diseases
Bansal Laboratory Focusing on the role of Matrix Metalloproteinase-2 in liver fibrosis and regeneration and Role of the chemokine receptors, CXCR4 and CCR5, on stellate cell biology and fibrogenesis
Bashir Laboratory Researching bioinformatics/ computational biology topics, primarily on problems related to genomic architecture
Birtwistle Laboratory Integrating computational and experimental methods to study single-cell cancer systems biology and pharmacology, with particular focus on glioblastoma
Blitzer Laboratory Studying cellular mechanisms giving rise to stable forms of synaptic plasticity in the brain, especially signaling pathways that regulate protein synthesis following synaptic stimulation
Campbell Laboratory Utilizing cell-based assays and rodent models to identify and characterize key mediators of glomerular disease progression
Casaccia Laboratory Integrating state-of-the-art technologies, animal models and drug discovery to promote excellence in myelin repair
Chaudhry Laboratory Focusing on cell cycle regulation of cardiomyocytes and endogenous progenitor cells in the heart
Benjamin Chen Laboratory Investigating the biology of HIV assembly and viral infection through virological synapses
Shu-Hsia Chen Laboratory Exploring the activation of innate and adaptive immunity
John Cijiang He Research Studying the role of HIPK2 in kidney fibrosis
Costa Laboratory Focusing on cell cycle regulation of cardiomyocytes and endogenous progenitor cells in the heart
Dar Laboratory Exploring links between the regulation of drug targets and the system level properties of biological networks within cells and animals
DeVita Research Group Focused on drug discovery to meet the needs of patients for whom there are limited therapeutic options
Dubois Laboratory Using the human pluripotent stem cell model to investigate cellular and molecular mechanisms of cell fate specification and disease in the early human heart
Devi Laboratory Exploring the molecular mechanisms and functional implications of opioid receptor dimerization, and focusing on drug discovery to meet the needs of patients who have limited therapeutic options
Ellis-Davies Laboratory Researching optical methods and neurophysiology
Evan Flatow Research Conducting research in biomechanics/bioengineering, signal transduction, tendon biology, and tendon disease
Filizola Laboratory Engaging in computer-aided structural bio and drug design
Friedman Laboratory of Liver Research Researching the role of KLF6 in cell growth and human cancer, as well as molecular regulation of hepatic fibrosis
Gallo Laboratory – Systems Pharmacology and Brain Tumor Chemotherapy Researching brain tumors, neuro pharmacology, and chemotherapy
Gelb Research Group Focusing on disease gene discovery using genomic techniques and characterization of the biological roles of such genes in disease pathogenesis
Hajjar Laboratory (Wiener Family Cardiovascular Research Laboratories) Concentrating on gene therapy for heart failure and other cardiovascular diseases
Han Laboratory Identifying neurophysiological basis of susceptibility and resilience to chronic stress at molecular (ion channel and receptor) and cellular levels
Hof Laboratory Studying selective neuronal vulnerability in dementing illnesses using classical neuropathological as well as modern quantitative immunohistochemical methods
Huang Laboratory Researching molecular and mechanical regulation of stem cell induction and differentiation
Hurd Lab Investigating the neurobiology underlying drug abuse and related psychiatric disorders
Iyengar Laboratory Exploring how signals are routed and processed through cellular signaling networks, including information sorting and integration mechanisms
Jin Laboratory Discovering chemical probes for histone methyltransferases (HMTs) and creating functionally selective ligands of G protein-coupled receptors
Kenny Laboratory Researching applications in behavioral and molecular neuroscience
Krulwich Laboratory Studying ion-translocating membrane transporters in bacterial cells are critical participants in the physiology of both pathogens and non-pathogenic bacteria of ecological interest
Lebeche Laboratory Targeting molecular and cellular pathways to improve contractile function and survival in failing cardiac myocytes
Lemischka Laboratory Investigating molecular and cellular nature of the undifferentiated stem cell "states", and how such states are altered during a change in cell fate
Neves Laboratory Studying how inhomogeneities in signaling events contribute to signal specificity in neuronal transmission
Ma’ayan Laboratory Applying computational and mathematical methods to study the complexity of regulatory networks in mammalian cells
Maze Laboratory Exploring the role of chromatin dynamics, nucleosomal turnover, and histone variant exchange in the central nervous system during periods of transcriptional, synaptic, and behavioral plasticity
Garcia-Ocana Research – Diabetes, Obesity and Metabolism Institute (DOMI) Focusing on tissue regeneration, growth factors, and intracellular signaling
Michael Ohlmeyer Research Studying applications in structural and chemical biology
Orthopedics Research Laboratory Using multidisciplinary approaches to address fundamental questions in the field of orthopaedic research
Roman Osman Research Studying proteolysis by integral membrane proteins,and blocking antigen presentation in autoimmunity and targeting MAGE inhibition of apoptosis
Palese Laboratory Focusing on fundamental questions concerning the genetic make-up and biology of viruses, as well as virus-host interactions
Parekh Laboratory Working to decipher the interplay between PDEs and synaptic responsiveness
Paisan-Ruiz Laboratory Studying Mantle Cell Lymphoma (MCL), a rare and usually fatal subtype of non-Hodgkin’s lymphoma, in collaboration with a Phase II clinical trial at the NIH
Parsons Laboratory Identifying the underpinnings of cancer and to using this information to improve prevention and treatment
Reddy Laboratory Studying genes that control cell homeostasis and how these controls are dysregulated during the neoplastic process
Ramirez Laboratory Characterizing multiple roles of extracellular matrix during vertebrate organogenesis and in disorders of connective tissue
Michael J. Ross Research Leading studies into the mechanisms of HIV-associated kidney diseases and is actively engaged in clinical and translational research
Russo Laboratory Researching neural adaptation to stress and drugs leading to altered synaptic connectivity and behavioral changes related to depression and addiction
Sanchez Laboratory Investigating protein sequence related to structure and function, as well as various biological systems
Lisa Satlin Research Defining the mechanisms leading to the acquisition, maintenance and regulation of transepithelial transport in the mammalian cortical collecting duct
Schaniel Laboratory Researching integrated stem cell biology; genomics; regenerative biology; and pharmacology Reprogramming, disease modeling and therapeutics with pluripotent stem cells
Schlessinger Laboratory Developing and applying novel computational approaches and collaboratively characterizing proteins that may be pharmacologically important in future cancer therapies
Donald Scott Research - Diabetes, Obesity and Metabolism Institute (DOMI) Working on the nutritional regulation of cellular phenotype
Sealfon Laboratory Using diverse systems biology approaches to study and model the mechanisms of cellular decoding of extracellular stimuli
Shapiro Laboratory Studying the neural mechanisms of memory in the everyday sense of the word: the ability to learn new facts and remember recent events
Sobie Laboratory Increasing a fundamental understanding of how calcium signaling in heart cells interacts with and influences the heart’s electrical and mechanical functions
Andrew Stewart Research Striving to understand and develop novel means for inducing the replication and regeneration of insulin-producing pancreatic beta cells
Ubarrextena Laboratory Conducting research in structural and chemical biology; Unraveling molecular etiology of neurodegenerative disorders employing high-resolution electron cryomicroscopy
Vasavada Laboratory - Diabetes, Obesity and Metabolism Institute (DOMI) Researching the pathways and mechanisms that regulate beta cell growth, survival and function, with the ultimate objective being to enhance regeneration of functional beta cells in vivo
Martin Walsh Research Investigating applications in structural and chemical biology, genetic and genomic sciences
Yue Laboratory Delving into the molecular and cellular mechanisms of neurodegeneration that causes human
Zhou Laboratory Researching molecular mechanisms of neuronal birth, extend axons, regeneration or failure to regenerate after mammalian CNS injury
Zou Laboratory Researching molecular mechanisms of neuronal birth, extend axons, regeneration or failure to regenerate after mammalian CNS injury