Barbara Murphy

Barbara Murphy, MD

  • DEAN FOR CLINICAL INTEGRATION AND POPULATION HEALTH
  • PROFESSOR AND SYSTEM CHAIR | Medicine, Nephrology

Specialties:

Kidney / Pancreas Transplantation, Nephrology

Barbara Murphy, MD is the Murray M. Rosenberg Professor of Medicine, Chair of the Department of Medicine for the Mount Sinai Health System and Dean for Clinical Integration and Population Health. Her area of interest is transplant immunology, focusing on the use of high throughput genomic technologies as a means to understand the immune mechanisms that lead to graft injury and loss, with the aim of identifying gene expression profiles and or genetic variants that may be used to predict those at greatest risk.

Dr. Murphy earned her M.B. B.A.O. B.Ch. from The Royal College of Surgeons in Ireland and went on to do an internship at Beaumont Hospital in Dublin. She completed a residency rotation at Beaumont Hospital followed by a fellowship in Clinical Nephrology also at Beaumont Hospital. Dr. Murphy completed her postdoctoral training with a fellowship in Nephrology at Brigham and Women's Hospital, Harvard Medical School. As part of this she trained in transplant immunology at the Laboratory of Immunogenetics and Transplantation, Renal Division, Brigham and Women's Hospital, Harvard Medical School. Among her many honors, Dr. Murphy was awarded the Young Investigator Award in Basic Science by the American Society of Transplantation in 2003. In 2005, Dr. Murphy was awarded the Irene and Dr. Arthur M. Fishberg Professor of Medicine at The Mount Sinai Hospital. Then, in 2011, she was named Nephrologist of the Year by the American Kidney Fund. She received the distinguished Jacobi Medallion in 2014. She also received an honorary degree from University College, Dublin, Ireland. In 2016, Dr. Murphy was honored by The Annual Irish America Healthcare & Life Science 50.

Dr. Murphy belongs to a number of professional societies including the American Society of Transplantation and the American Society of Nephrology. Among her numerous achievements, she has held many leadership roles at a national level, including being a member of the Board of the American Society of Transplantation, the Executive Committee of the American Transplant Congress, and Chair of Education Committee of the American Society of Transplantation. Most recently, she served as the president of the American Society of Transplantation and is currently the Co-Chair of the American Society of Transplantation Public Policy. In 2016, The American Society of Nephrology elected Dr. Murphy as its newest Councilor. In these positions, Dr. Murphy aims to directly impact patient care and access to healthcare, specifically, advocating for long-term coverage for immunosuppression.

Dr. Murphy is the Principle Investigator of a study, the Genomics of Chronic Renal Allograft Rejection, (GoCar), which aims to investigate the mechanisms leading to the development of transplant glomerulopathy, chronic arteriopathy funded through the NIH/NIAID Genomics Consortium in Transplantation. TheGoCar study, recently published in The Lancet, examines the contribution of the direct and indirect pathways of allorecognition, and the development of de novo donor specific antibodies to this pathologic finding in a large prospective group of renal transplant recipients. The study is examining the gene expression profile associated with the development of chronic rejection using microarray on protocol biopsies performed over two years following transplantation. In addition, a larger cohort of donor and recipient pairs are being enrolled to identify polymorphic variants of specific immunological genes which confer susceptibility to chronic rejection and the development of donor specific antibodies.

Dr. Murphy's Lab also investigated a systems biology approach to the identification of genetic drivers of fibrosis in the allograft and the potential application to native kidney. Through this mechanism they have identified several novel mediators of fibrosis which are being investigated further in humans and animal models. SHROOM3 is one such gene. An intronic SNP in SHROOM3 increases expression of SHROOM3 and drives fibrosis in human allograft recipients and murine models of CKD. Her research was published in The Journal of Clinical Investigation.

Dr. Murphy was the PI of a large multicenter NIH study investigating the role of genomic to predict the development of chronic allograft nephropathy.  She was a co-investigator on the landmark study investigating outcomes in HIV-positive patients that received a solid organ transplant. To read more about Dr. Murphy's research, please visit The Murphy Lab.

Clinical Focus


Multi-Disciplinary Training Area

Immunology [IMM]

Education

MB BAO BCh, The Royal College of Surgeons

MD, Royal College of Surgeons-Ireland

MRCPI, The Royal College of Physicians

FRCPI, The Royal College of Physicians

Internship, Internal Medicine, Beaumont Hospital

Fellowship, Nephrology, Beaumont Hospital

Fellowship, Nephrology-Renal, Brigham and Women's Hospital, Harvard Medical School

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