We are hiring faculty! If you are interested, please e-mail Julie Sazant and Dr. Filip Swirski with your cover letter and CV.

Please click here to access the CVRI intranet for CVRI members

Pioneering, multidisciplinary, and collaborative. The Cardiovascular Research Institute (CVRI) at Mount Sinai, under the auspices of Mount Sinai Heart, is committed to elucidating the workings of the heart and blood in the broader physiological context.

The cardiovascular system is part of an intricate network that involves many tissue, cellular, and molecular processes. The immune, endocrine, metabolic, and hematopoietic systems, just to name a few—all play a role in our cardiovascular health. Understanding the mechanisms of inter-system communication is key to innovation in fundamental and translational science.

Promoting an Organic Exchange of Knowledge and Discovery

Just as the heart cannot be understood in isolation, our Institute cannot thrive in isolation. We collaborate with other research entities to grow our understanding of the body in its larger context. We are establishing relationships with researchers within the Mount Sinai community, with other New York cardiovascular institutes, and with numerous national and international organizations. We actively share our knowledge, insights, and discoveries, and draw inspiration and momentum from the work of our colleagues.

The ISMMS Scholars Portal

Cardiovascular Research Institute on the Icahn School of Medicine Scholars Portal

The ISMMS Scholars Portal tracks publications and other kinds of research output, people, projects and grants, research units (departments, institutions, centers), datasets, and research-related activities within the CVRI. 

CVRI @ 2nd Annual NYC Inter-Institutional Cardiovascular Research Series!

The CVRI joined their colleagues at the St. Francis Hospital & Heart Center, Columbia University, NYU Langone Health, Rutgers NJ Medical School, Albert Einstein College of Medicine, and Weill Cornell on September 14th at the NYIT Seversky Mansion for a great retreat! Thank you to all involved for the wonderful opportunity to connect with fellow scientists in the area and for the wonderful day of connections and excellent talks and posters.

Latest CVRI Publications!

This list is updated periodically with the senior authored publication from primary CVRI labs.

Recessive TMOD1 mutation causes childhood cardiomyopathy.Vasilescu C, Colpan M, Ojala TH, Manninen T, Mutka A, Ylänen K, Rahkonen O, Poutanen T, Martelius L, Kumari R, Hinterding H, Brilhante V, Ojanen S, Lappalainen P, Koskenvuo J, Carroll CJ, Fowler VM, Gregorio CC*, Suomalainen A Commun Biol. 2024 Jan 2;7(1):7. doi: 10.1038/s42003-023-05670-9.PMID: 38168645 *Corresponding Author

Whole-Exome Sequencing Identifies Homozygote Nonsense Variants in LMOD2 Gene Causing Infantile Dilated Cardiomyopathy. Sono R, Larrinaga TM, Huang A, Makhlouf F, Kang X, Su J, Lau R, Arboleda VA, Biniwale R, Fishbein GA, Khanlou N, Si MS, Satou GM, Halnon N, Ucla Congenital Heart Defects-BioCore Faculty, Van Arsdell GS, Gregorio CC, Nelson S, Touma M. Cells. 2023 May 23;12(11):1455. doi: 10.3390/cells12111455.PMID: 37296576 

A nemaline myopathy-linked mutation inhibits the actin-regulatory functions of tropomodulin and leiomodin.Schultz LE, Colpan M, Smith GE Jr, Mayfield RM, Larrinaga TM, Kostyukova AS, Gregorio CC. Proc Natl Acad Sci U S A. 2023 Nov 21;120(47):e2315820120. doi: 10.1073/pnas.2315820120. Epub 2023 Nov 13.PMID: 37956287

Lifetime evaluation of left ventricular structure and function in male ApoE null mice after gamma and space-type radiation exposure. Brojakowska A, Jackson CJ, Bisserier M, Khlgatian MK, Jagana V, Eskandari A, Grano C, Blattnig SR, Zhang S, Fish KM, Chepurko V, Chepurko E, Gillespie V, Dai Y, Kumar Rai A, Garikipati VNS, Hadri L, Kishore R, Goukassian DA.  Front Physiol. 2023 Nov 20;14:1292033. doi: 10.3389/fphys.2023.1292033.

Nanotherapeutic Heterogeneity: Sources, Effects, and Solutions. Morla-Forch, J., Ranzenigo, A., Fayad, Z.A., Teunissen, A. Dec 2023. Nano Micro Small. https://doi.org/10.1002/smll.202307502

Effects of lifestyle factors on leukocytes in cardiovascular health and disease. Janssen, H., Koekkoek, L.L., Swirski, F.K. Sept 2023. Nature Reviews Cardiology. doi: 10.1038/s41569-023-00931-w.

CCND2 Modified mRNA Activates Cell Cycle of Cardiomyocytes in Hearts With Myocardial Infarction in Mice and Pigs. Sun, J., Wang, L., Matthews, R.C., Walcott, G.P., Lu, Y., Wei, Y., Zhou, Y., Zangi, L. and Zhang, J. Aug 2023. Circulation Research. https://doi.org/10.1161/CIRCRESAHA.123.322929

Extracellular Vesicle–Encapsulated Adeno-Associated Viruses for Therapeutic Gene Delivery to the Heart. Li, X., La Salvia, S., Liang, Y., Adamiak, M., Kohlbrenner, E., Jeong, D., Chepurko, E., Ceholski, D., Lopez-Gordo, E., Yoon, S., Mathiyalagan, P., Agarwal, N., Jha, D., Lodha, S., Daaboul, G., Phan, A., Raisinghani, N., Zhang, S., Zangi, L., Gonzalez-Kozlova, E., Dubois, N., Dogra, N., Hajjar, R.J., Sahoo, S. Jul 2023. Circulation. 148:405-425.

Accompanying podcast episode (7m 15s) for the above article!

Interleukin-3 coordinates glial-peripheral immune crosstalk to incite multiple sclerosis. Kiss M., Mindur J., Yates A., Lee D., Fullar J., Anzai A., Poller W., Christie K., Iwamoto Y., Roudko V., Downey J., Chan C., Huynh P., Janssen H., Ntranos A., Hoffmann J., Jacob W., Goswami S., Singh S., Leppert D., Kuhle J., Kim-Schulze S., Nahrendorf M., Kleinstiver B., Probert F., Roussos P., Swirski F., McAlpine C. May 2023. Immunity. (56)1-13.

Monocytes re-enter the bone marrow during fasting and alter the host response to infection. Janssen, H., Kahles, F., Liu, D., Downey, J., Koekkoek, L. L., Roudko, V., D'Souza, D., McAlpine, C. S., Halle, L., Poller, W. C., Chan, C. T., He, S., Mindur, J. E., Kiss, M. G., Singh, S., Anzai, A., Iwamoto, Y., Kohler, R. H., Chetal, K., Sadreyev, R. I., Weissleder, R., Kim-Schulze, S., Merad, M., Nahrendorf, M., Swirski, F.K. Apr 2023, In: Immunity. 56, 4, p. 783-796.e7

Multiparametric Immunoimaging Maps Inflammatory Signatures in Murine Myocardial Infarction Models. Maier, A., Toner, Y. C., Munitz, J., Sullivan, N. A. T., Sakurai, K., Meerwaldt, A. E., Brechbühl, E. E. S., Prévot, G., van Elsas, Y., Maas, R. J. F., Ranzenigo, A., Soultanidis, G., Rashidian, M., Pérez-Medina, C., Heo, G. S., Gropler, R. J., Liu, Y., Reiner, T., Nahrendorf, M., Swirski, F. K., & 6 othersStrijkers, G. J., Teunissen, A. J. P., Calcagno, C., Fayad, Z. A., Mulder, W. J. M. & van Leent, M. M. T. Apr 2023. JACC: Basic to Translational Science. 

18F-FDG PET/CT In The Characterization And Management Of Continuous Flow Left Ventricular Assist Device Infection. Rashed, E., Devesa, A., Moss, N., Robson, P., Pyzik, R., Roldan, J., Mancini, D., Ashley, K., Gavane, S.C., Ghesani, M., Contreras, J., Lala, A., Parikh, A., Young, A., Ghesani, N., Jacobi, A., Fayad, Z., Mahmoud, K., Trivieri, M. Apr 2023, Journal of Cardiac Failure. 127, 29, 4, P607.

Lifetime Evaluation of Left Ventricular Structure and Function in Male C57BL/6J Mice after Gamma and Space-Type Radiation Exposure. Brojakowska, A., Jackson, C. J., Bisserier, M., Khlgatian, M. K., Grano, C., Blattnig, S. R., Zhang, S., Fish, K. M., Chepurko, V., Chepurko, E., Gillespie, V., Dai, Y., Lee, B., Garikipati, V. N. S., Hadri, L., Kishore, R. & Goukassian, D. A. Mar 2023, International Journal of Molecular Sciences. 24, 6, 5451. 

Diversity, Equity, and Inclusion Statement

The CVRI is committed to fostering an inclusive and collaborative work environment in which all ideas and identities are valued. We welcome and respect members of any age, sexual orientation, gender identity or expression, nationality, religion, race/ethnicity, disability status, or socioeconomic status. Scientific discoveries come from the integration of diverse perspectives, discussions, and ideas and we are committed to nurturing this type of environment.