Selected Publications

Wang X, Wu D, Yang L, Gan L, Cederbaum AI. Cytochrome P450 2E1 potentiates ethanol induction of hypoxia and HIF-1α in vivo. Free Radic Biol Med. 2013 Oct;63:175-86.

Lu Y, Ward SC, Cederbaum AI. Nicotine enhances ethanol-induced fat accumulation and collagen deposition but not inflammation in mouse liver. Alcohol. 2013 Aug;47(5):353-7.

Cederbaum AI. Nrf2 and Antioxidant Defense Against CYP2E1 Toxicity. Subcell Biochem. 2013;67:105-30. 

Cederbaum AI. CYP2E1 potentiates toxicity in obesity and after chronic ethanol treatment. Drug Metabol Drug Interact. 2012;27(3):125-44. 

Cederbaum AI. Alcohol metabolism. Clin Liver Dis. 2012 Nov;16(4):667-85.

Wu D, Wang X, Zhou R, Yang L, Cederbaum AI. Alcohol steatosis and cytotoxicity: the role of cytochrome P4502E1 and autophagy. Free Radic Biol Med. 2012 Sep 15;53(6):1346-57.

Yang L, Wu D, Wang X, Cederbaum AI. Cytochrome P4502E1, oxidative stress, JNK, and autophagy in acute alcohol-induced fatty liver. Free Radic Biol Med. 2012 Sep 1;53(5):1170-80.

Lu Y, Zhang XH, Cederbaum AI. Ethanol induction of CYP2A5: role of CYP2E1-ROS-Nrf2 pathway. Toxicol Sci. 2012 Aug;128(2):427-38.

An L, Wang X, Cederbaum AI. Cytokines in alcoholic liver disease. Arch Toxicol. 2012 Sep;86(9):1337-48.

Cederbaum AI, Yang L, Wang X, Wu D. CYP2E1 Sensitizes the Liver to LPS- and TNF α-Induced Toxicity via Elevated Oxidative and Nitrosative Stress and Activation of ASK-1 and JNK Mitogen-Activated Kinases. Int J Hepatol. 2012;2012:582790.

Wang X, Wu D, Yang L, Cederbaum AI. Hepatotoxicity mediated by pyrazole (cytochrome P450 2E1) plus tumor necrosis factor alpha treatment occurs in c-Jun N-terminal kinase 2-/- but not in c-Jun N-terminal kinase 1-/- mice. Hepatology. 2011 Nov;54(5):1753-66.

Andreo U, Elkind J, Blachford C, Cederbaum AI, Fisher EA. Role of superoxide radical anion in the mechanism of apoB100 degradation induced by DHA in hepatic cells. FASEB J. 2011 Oct;25(10):3554-60.

Yang L, Wu D, Wang X, Cederbaum AI. Depletion of cytosolic or mitochondrial thioredoxin increases CYP2E1-induced oxidative stress via an ASK-1-JNK1 pathway in HepG2 cells. Free Radic Biol Med. 2011 Jul 1;51(1):185-96.

Lu Y, Zhuge J, Wu D, Cederbaum AI. Ethanol-induction of cytochrome P450 2A5: Permissive role for CYP2E1. Drug Metab Dispos. 2011 Feb;39(2):330-6.

Lu Y, Wu D, Wang X, Ward SC, Cederbaum AI. Chronic alcohol-induced liver injury and oxidant stress are decreased in cytochrome P4502E1 knockout mice and restored in humanized cytochrome P4502E1 knock-in mice. Free Radic Biol Med. 2010 Nov 15;49(9):1406-16.

Wu D, Wang X, Zhou R, Cederbaum A. CYP2E1 enhances ethanol-induced lipid accumulation but impairs autophaghy in HepG2 E47 cells. Biochem Biophys Res Commun. 2010 Oct 11.

Wu D, Cederbaum A. Activation of ASK-1 and downstream MAP kinases in cytochrome P4502E1 potentiates tumor necrosis factor alpha liver injury. Free Radic Biol Med. 2010 Aug 1;49(3):348-60.

Cederbaum AI. Hepatoprotective effects of S-adenosyl-L-methionine against alcohol- and cytochrome P450 2E1-induced liver injury. World J Gastroenterol. 2010 Mar 21;16(11):1366-76.

Cederbaum A. Nrf2 and antioxidant defense against CYP2E1 toxicity. Expert Opin Drug Metab Toxicol. 2009 Oct;5(10):1223-44. 

Lu Y, Cederbaum AI. CYP2E1 potentiation of LPS and TNFalpha-induced hepatotoxicity by mechanisms involving enhanced oxidative and nitrosative stress, activation of MAP kinases, and mitochondrial dysfunction. Genes Nutr. 2009 Oct 2.

Wu D, Cederbaum AI. Oxidative stress and alcoholic liver disease. Semin Liver Dis. 2009 May;29(2):141-54.

Lu Y, Gong P, Cederbaum AI. Pyrazole induced oxidative liver injury independent of CYP2E1/2A5 induction due to Nrf2 deficiency. Toxicology. 2008 Oct 30;252(1-3):9-16.

Wang X, Lu Y, Xie B, Cederbaum AI. Chronic ethanol feeding potentiates Fas Jo2-induced hepatotoxicity: role of CYP2E1 and TNF-alpha and activation of JNK and P38 MAP kinase. Arch Toxicol. 2009 Jun;83(6):519-48.

Caro AA, Evans KL, Cederbaum AI. CYP2E1 overexpression inhibits microsomal Ca2 -ATPase activity in HepG2 cells. Toxicology. 2009 Jan 31;255(3):171-6.

Zhuge J, Cederbaum AI. Inhibition of the mitochondrial permeability transition by cyclosporin A prevents pyrazole plus lipopolysaccharide-induced liver injury in mice. Free Radic Biol Med. 2009 Feb 1;46(3):406-13.

Wang X, Cederbaum AI. S-adenosyl-L-methionine decreases the elevated hepatotoxicity induced by Fas agonistic antibody plus acute ethanol pretreatment in mice. Arch Biochem Biophys. 2008 Sep 1;477(1):1-11.

Lu Y, Zhuge J, Wang X, Bai J, Cederbaum AI. Cytochrome P450 2E1 contributes to ethanol-induced fatty liver in mice. Hepatology. 2008 May;47(5):1483-94.

Wu D, Cederbaum AI. Development and Properties of HepG2 Cells That Constitutively Express CYP2E1. Methods Mol Biol. 2008;447:137-50.

Lu Y, Cederbaum AI. CYP2E1 and oxidative liver injury by alcohol. Free Radic Biol Med. 2008 Mar 1;44(5):723-38.

Jimenez-Lopez JM, Wu D, Cederbaum AI. Synergistic toxicity induced by prolonged glutathione depletion and inhibition of nuclear factor-kappaB signaling in liver cells. Toxicol In Vitro. 2008 Feb;22(1):106-15.

Zhuge J, Cederbaum AI. Depletion of S-adenosyl-l-methionine with cycloleucine potentiates cytochrome P450 2E1 toxicity in primary rat hepatocytes. Arch Biochem Biophys. 2007 Oct 15;466(2):177-85.

Dey A, Cederbaum AI. Induction of cytochrome P450 2E1 [corrected] promotes liver injury in ob/ob mice. Hepatology. 2007 Jun;45(6):1355-65.

Kessova IG, Cederbaum AI. Mitochondrial alterations in livers of Sod1-/- mice fed alcohol. Free Radic Biol Med. 2007 May 15;42(10):1470-80.

Dey A, Caro AA, Cederbaum AI. S-adenosyl methionine protects ob/ob mice from CYP2E1-mediated liver injury. Am J Physiol Gastrointest Liver Physiol. 2007 Jul;293(1):G91-103.

Dey A, Cederbaum AI. Geldanamycin, an inhibitor of Hsp90 increases cytochrome P450 2E1 mediated toxicity in HepG2 cells through sustained activation of the p38MAPK pathway. Arch Biochem Biophys. 2007 May 15;461(2):275-86.

Wang X, Cederbaum AI. Acute ethanol pretreatment increases FAS-mediated liver injury in mice: role of oxidative stress and CYP2E1-dependent and -independent pathways. Free Radic Biol Med. 2007 Apr 1;42(7):971-84.

Caro AA, Cederbaum AI. Role of intracellular calcium and phospholipase A2 in arachidonic acid-induced toxicity in liver cells overexpressing CYP2E1. Arch Biochem Biophys. 2007 Jan 15;457(2):252-63.

Bai J, Cederbaum AI. Cycloheximide protects HepG2 cells from serum withdrawal-induced apoptosis by decreasing p53 and phosphorylated p53 levels. J Pharmacol Exp Ther. 2006 Dec;319(3):1435-43.

Zhuge J, Cederbaum AI. Increased toxicity by transforming growth factor-beta 1 in liver cells overexpressing CYP2E1. Free Radic Biol Med. 2006 Oct 1;41(7):1100-12.

Cederbaum AI. Cytochrome P450 2E1-dependent oxidant stress and upregulation of anti-oxidant defense in liver cells. J Gastroenterol Hepatol. 2006 Oct;21 Suppl 3:S22-5.

Cederbaum AI. CYP2E1--biochemical and toxicological aspects and role in alcohol-induced liver injury. Mt Sinai J Med. 2006 Jul;73(4):657-72.

Jimenez-Lopez JM, Cederbaum AI. CYP2E1-dependent oxidative stress and toxicity: role in ethanol-induced liver injury. Expert Opin Drug Metab Toxicol. 2005 Dec;1(4):671-85.

Lu Y, Cederbaum AI. Enhancement by pyrazole of lipopolysaccharide-induced liver injury in mice: role of cytochrome P450 2E1 and 2A5. Hepatology. 2006 Jul;44(1):263-74.

Caro AA, Cederbaum AI. Role of phosphatidylinositol 3-kinase/AKT as a survival pathway against CYP2E1-dependent toxicity. J Pharmacol Exp Ther. 2006 Jul;318(1):360-72.

Gong P, Cederbaum AI. Transcription factor Nrf2 protects HepG2 cells against CYP2E1 plus arachidonic acid-dependent toxicity. J Biol Chem. 2006 May 26;281(21):14573-9.

Bai J, Cederbaum AI. Adenovirus-Mediated Expression of CYP2E1 Produces Liver Toxicity in Mice. Toxicol Sci. 2006 Jun;91(2):365-71.

Dey A, Cederbaum AI. Geldanamycin, an Inhibitor of Hsp90, Potentiates Cytochrome P4502E1-Mediated Toxicity in HepG2 Cells. J Pharmacol Exp Ther. 2006 Jun;317(3):1391-9.

Gong P, Cederbaum AI. Transcription factor Nrf2 protects HepG2 cells against CYP2E1 plus arachidonic acid-dependent toxicity. J Biol Chem. 2006 May 26;281(21):14573-9.

Wang X, Cederbaum AI. S-adenosyl-L-methionine attenuates hepatotoxicity induced by agonistic Jo2 Fas antibody following CYP2E1 induction in mice. J Pharmacol Exp Ther. 2006 Apr;317(1):44-52.

Wu D, Cederbaum AI. Opposite action of S-adenosyl methionine and its metabolites on CYP2E1-mediated toxicity in pyrazole-induced rat hepatocytes and HepG2 E47 cells. Am J Physiol Gastrointest Liver Physiol. 2006 Apr;290(4):G674-84.

Dey A, Kessova IG, Cederbaum AI. Decreased protein and mRNA expression of ER stress proteins GRP78 and GRP94 in HepG2 cells over-expressing CYP2E1. Arch Biochem Biophys. 2006 Mar 15;447(2):155-66.

Bai J, Cederbaum AI. Overexpression of CYP2E1 in mitochondria sensitizes HepG2 cells to the toxicity caused by depletion of glutathione. J Biol Chem. 2006 Feb 24;281(8):5128-36.

Caro AA, Cederbaum AI. Role of cytochrome P450 in phospholipase A2- and arachidonic acid-mediated cytotoxicity. Free Radic Biol Med. 2006 Feb 1;40(3):364-75.

Dey A, Cederbaum AI. Alcohol and oxidative liver injury. Hepatology. 2006 Feb;43(2 Suppl 1):S63-74.

Lu Y, Cederbaum AI. Cisplatin-induced hepatotoxicity is enhanced by elevated expression of cytochrome P450 2E1. Toxicol Sci. 2006 Feb;89(2):515-23.

Gong P, Cederbaum AI. Nrf2 is increased by CYP2E1 in rodent liver and HepG2 cells and protects against oxidative stress caused by CYP2E1. Hepatology. 2006 Jan;43(1):144-53.

Zhuge J, Cederbaum AI. Serum deprivation-induced HepG2 cell death is potentiated by CYP2E1. Free Radic Biol Med. 2006 Jan 1;40(1):63-74.

Kessova IG, Cederbaum AI. The Effect of CYP2E1-Dependent Oxidant Stress on Activity of Proteasomes in HepG2 Cells. J Pharmacol Exp Ther. 2005 Oct;315(1):304-12.

Nieto N, Cederbaum AI. S-adenosylmethionine blocks collagen I production by preventing TGFbeta induction of the COL1A2 promoter. J Biol Chem. 2005 Sep 2;280(35):30963-74.

Wu D, Cederbaum AI. Oxidative stress mediated toxicity exerted by ethanol-inducible CYP2E1. Toxicol Appl Pharmacol. 2005 Sep 1;207(2 Suppl):70-6.

Lu Y, Wang X, Cederbaum AI. Lipopolysaccharide-induced liver injury in rats treated with the CYP2E1 inducer pyrazole. Am J Physiol Gastrointest Liver Physiol. 2005 Aug;289(2):G308-19.

Wang X, Lu Y, Cederbaum AI. Induction of cytochrome P450 2E1 increases hepatotoxicity caused by Fas agonistic Jo2 antibody in mice. Hepatology. 2005 Aug;42(2):400-10.

Caro AA, Cederbaum AI. Inhibition of CYP2E1 catalytic activity in vitro by S-adenosyl-L-methionine. Biochem Pharmacol. 2005 Apr 1;69(7):1081-93.

Jimenez-Lopez JM, Cederbaum AI. Protein Kinase C Signaling as a Survival Pathway Against CYP2E1-Derived Oxidative Stress and Toxicity in HepG2 Cells. J Pharmacol Exp Ther 2005 Mar; 312(3):998-1006.

Carmiel-Haggai M, Cederbaum AI, Nieto N. A high-fat diet leads to the progression of non-alcoholic fatty liver disease in obese rats. FASEB J 2005 Jan; 19(1):136-38.


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