Disease-Specific Genes 

Below is the list of disease-specific genes that are tested in our Laboratory.

  • Hematological malignancies 
    • Chronic Myelogenous Leukemia (CML): BCR-ABL, BCR-ABL-ASS 
    • Ph Negative Myeloproliferative Neoplasam (MPN): PDGFRB, EGR1, CEP7/7q31, CEP8, CEP9/9p21, AT<, RB1, D20S108 
    • Hypereosinophilic syndrome: FIP1L1 
    • Myelodysplastic Syndrome (MDS): EGR1, CEP7, 7q31,CEP8, RB1, MLL, ETV6, D20S108 
    • Acute Myelogenous Leukemia (AML): BCR-ABL, ETO-AML1,PML-RARA, CBFB,MLL 
    • Therapy-related AML: EGR1,CEP7/7q31, 21q22, MLL 
    • Acute Lymhoblastic Leukemia – Pediatric (ALL): BCR-ABL, ETV6-AML1, TCF3-PBX1, P15-P16 at 9p21, MLL, CEP4, CEP10, CEP17 
    • Acute Lymphoblastic Leukemia – Adult: BCR-ABL, CEP7/7q31, P15-P16 at 9p21, MLL 
    • Chronic Lymphocytic Leukemia (CLL): CEP12, D13S319/LAMP1, IGH, ATM, P53 
    • Multiple Myeloma (MM): CCND1-IGH, FGFR3-IGH, MAF-IGH, 1q21,PBX1-TCF3 ,P53, ATM, 5q33, D13S319/LAMP1, ASS 
    • Non Hodgkins Lymphoma (NHL): IGH-BCL2, MYC-IGH, CCND1-IGH, API2-MALT1, BCL6, ALK 
    • Chimerism and Minimal residual disease in stem cell transplantations: XX/XY

  • Solid Tumors 
    • Breast Cancer: HER2 
    • Bladder Cancer: UrovysionR: CEP3,CEP7,9p21 and CEP17 
    • Neuroblastoma: N-MYC 
    • Sarcoma (Ewing: EWSR1, Synovia: SYT, Alveolar Rhabdosarcoma: FOXO1A, Malignant liposarcomna: FUS) 
    • Oligodendroglioma: 1p36, 1q25; 19p13, 19q13 
    • Lung Cancer: ALK 
    • Cholangiocarcinoma: UrovysionR: CEP3, CEP7, 9p21 and CEP17 

We are currently developing a three color ERG probe assay for prostate cancer.