Recognition and Publications

Contributions from members of our Molecular Pharmacology Laboratory

Publications

1. Gonzalez-Maeso, J., Rodriguez-Puertas, R., Meana, J.J., Garcia-Sevilla, J.A., and Guimon, J. (2002) Neurotransmitter receptor-mediated activation of G-proteins in brains of suicide victims with mood disorders: selective supersensitivity of alpha(2A)-adrenoceptors. Mol Psychiatry 7, 755-767
2. Gonzalez-Maeso, J., Weisstaub, N.V., Zhou, M., Chan, P., Ivic, L., Ang, R., Lira, A., Bradley-Moore, M., Ge, Y., Zhou, Q., Sealfon, S.C., and Gingrich, J.A. (2007) Hallucinogens Recruit Specific Cortical 5-HT(2A) Receptor-Mediated Signaling Pathways to Affect Behavior. Neuron 53, 439-452
3. Gonzalez-Maeso, J., Ang, R.L., Yuen, T., Chan, P., Weisstaub, N.V., Lopez-Gimenez, J.F., Zhou, M., Okawa, Y., Callado, L.F., Milligan, G., Gingrich, J.A., Filizola, M., Meana, J.J., and Sealfon, S.C. (2008) Identification of a serotonin/glutamate receptor complex implicated in psychosis. Nature 452, 93-97
4. Moreno, J.L., Kurita, M., Holloway, T., Lopez, J., Cadagan, R., Martinez-Sobrido, L., Garcia-Sastre, A., and Gonzalez-Maeso, J. (2011) Maternal Influenza Viral Infection Causes Schizophrenia-Like Alterations of 5-HT2A and mGlu2 Receptors in the Adult Offspring. J Neurosci 31, 1863-1872
5. Fribourg, M., Moreno, J.L., Holloway, T., Provasi, D., Baki, L., Mahajan, R., Park, G., Adney, S.K., Hatcher, C., Eltit, J.M., Ruta, J.D., Albizu, L., Li, Z., Umali, A., Shim, J., Fabiato, A., Mackerell, A.D., Jr., Brezina, V., Sealfon, S.C., Filizola, M., Gonzalez-Maeso, J., and Logothetis, D.E. (2011) Decoding the Signaling of a GPCR Heteromeric Complex Reveals a Unifying Mechanism of Action of Antipsychotic Drugs. Cell 147, 1011-1023
6. Kurita, M., Holloway, T., Garcia-Bea, A., Kozlenkov, A., Friedman, A.K., Moreno, J.L., Heshmati, M., Golden, S.A., Kennedy, P.J., Takahashi, N., Dietz, D.M., Mocci, G., Gabilondo, A.M., Hanks, J., Umali, A., Callado, L.F., Gallitano, A.L., Neve, R.L., Shen, L., Buxbaum, J.D., Han, M.H., Nestler, E.J., Meana, J.J., Russo, S.J., and Gonzalez-Maeso, J. (2012) HDAC2 regulates atypical antipsychotic responses through the modulation of mGlu2 promoter activity. Nat Neurosci 15, 1245-1254
7. Moreno J.L., Muguruza C., Umali A., Mortillo S., Holloway T., Pilar-Cuellar F., Mocci G., Hanks J., Seto J., Callado L.F., Milligan G., Sealfon S.C., Lopez-Gimenez J.F., Meana J.J., Benson D.L., and Gonzalez-Maeso J. Identification of three residues essential for 5-hydroxytryptamine 2A-metabotropic glutamate 2 (5-HT2A•mGlu2) receptor heteromerization and its psychoactive behavioral function. Journal of Biological Chemistry 287: 44301-44319 (2012)
8. Holloway T., Moreno J.L., Umali A., Rayannavar V., Hodes G.E., Russo S.J., and Gonzalez-Maeso J. Prenatal stress induces schizophrenia-like alterations of 5-HT2A and mGlu2 receptors in the adult offspring: Role of maternal immune system. Journal of Neuroscience 33, 1088-1098 (2013)

Reviews

1. Gonzalez-Maeso, J., and Meana, J.J. (2006) Heterotrimeric G proteins: Insights into the Neurobiology of Mood Disorders. Curr Neuropharmacol 4, 127-138
2. Gonzalez-Maeso, J., and Sealfon, S.C. (2009) Psychedelics and schizophrenia. Trends Neurosci 32, 225-232
3. Gonzalez-Maeso, J. (2011) GPCR oligomers in pharmacology and signaling. Mol Brain 4, 20
4. Hanks J.B, and Gonzalez-Maeso, J. Animal models of serotonergic psychedelics. ACS Chemical Neuroscience 4, 33-42 (2013)