Sealfon Laboratory - Icahn School of Medicine at Mount Sinai

Serotonin/Glutamate Receptor Colocalization

Fluorescent in situ hybridization (FISH) showing colocalization of Serotonin 2AR and metabotropic mGluR2, which form a functional complex in cortical neurons. Read More

Dendritic cell - T cell Interaction

Single-cell images acquired by imaging flow cytometry: CD3 (T cell marker, purple), CD11c (dendritic cell marker, orange), Draq5 (DNA marker), brightfield (BF, gray) overlay of the former three. Read More

Reverse Engineering for Functional Network

Functional network reverse engineered from expression and inhibition data using Plato's Cave Algorithm. Read More

Model of Dendritic Cell Response

Ordinary differential equation (ODE) model of flu-infected dendritic cells pretreated with interferon (partial view). Read More

Phagocytosis of Microspheres

Representative images showing examples of cells containing between one and seven beads imaged using enhanced depth of field-equipped imaging flow cytometry. Read More

Dendritic Cell Signaling Pathway Map

[Map detail] Created using CellDesigner ver.4.0.1, 4.0.α and 4.1β; black filled arrows, stimulatory reactions; red bar-headed lines, inhibitory reactions; pink lines, catalysis reactions. Read More

Gonadotrope Cell Signaling Pathway Map

[Map detail] Created using CellDesigner ver.4.0.1 and 4.0.α; black filled arrows, stimulatory reactions; red bar-headed lines, inhibitory reactions; dashed lines, transcription. Read More

Multiplex Quantum Dot FISH

Epsilon sarcoglycan (red) and Dopamine D2 receptor (green) mRNAs in mouse brainstem sections; overlay of both and tyrosine hydroxylase immunohistochemistry signal (blue). Read More

The Sealfon Laboratory uses diverse systems biology approaches to study and model the mechanisms of cellular decoding of extracellular stimuli.

NEWS

Stuart C. Sealfon, MD, Receives NARSAD Distinguished Investigator Award
May 14, 2010 - Stuart C. Sealfon, MD, Chairman of the Department of Neurology at Mount Sinai School of Medicine, receives the Distinguished Investigator Grant Award.

Elena Zaslavsky, PhD Wins DREAM4 Peptide Recognition Domain Challenge
December 4, 2009 - The paper describing the winning method will appear in a dedicated issue of PLoS One.

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Stuart Sealfon, MD
Tel: (212) 241-7075
Fax: (212) 289-4107

Annenberg Building
1468 Madison Avenue
Department of Neurology
14th Floor, Room 14-94; Box 1137
New York, NY 10029