Projects and Grants

R01 HL 078731
NIH/NHLBI
Genetic editing of Ca Cycling in Diabetic Cardiomyopathy
The major goal of this grant is to examine the role of various calcium cycling proteins in the development of diabetic cardiomyopathy.

R01 HL083156 (Hajjar)
NIH/NHLBI
Targeting Calcium Cycling in a Pre-Clinical Model of Cardiac Dysfunction
This project involves the use of AAV vectors for transferring the protein phosphatase inhibitor-1 to the failing heart in a porcine pre-clinical model that can be easily translatable to humans.

R01 HL080498 (Hajjar)
NIH/NHLBI
PICOT & Cardiac Hypertrophy
The major goal of this grant is to examine the role of PICOT in the development of cardiac hypertrophy and failure.

3R01HL080498-04S1
NIH/NHLBI
PICOT & Cardiac Hypertrophy
No overlap

1R01HL093183-01
NIH/NHLBI
Regression of Cardiac Hypertrophy
The major goal of this grant is to examine novel signaling pathways in the context of regression of cardiac hypertrophy.

1R01HL088434-01A1
NIH/NHLBI
Gene Therapy with Cardiotropic Vectors for the Treatment of Heart Failure
The major goal of this project is to develop novel mutant adeno associated type vectors that are cardiotropic and escape antecedent neutralizing antibodies in the treatment of heart failure.

1P20HL100396-01
NIH/NHLBI
C-TRIP: Targeted Gene Therapy for the Treatment of Heart Failure
The goal of this project is to test in the pre-clinical setting the effects of delivering I-1c gene for the treatment of heart failure.

R01 HL072265 (PI: Levine, Robert)
NIH/NHLBI
Effect of Mitral Regurgitation on Ischemic LV Remodeling
Our laboratory will develop and generate the AAV vectors necessary for the large animal experiments in this proposal.

1R01 HL097357 (PI: Lebeche, Djamel)
NIH/NHLBI
Genetic Analysis of MicroRNAs function in Diabetic Cardiomyopathy
The major goal of this project is to investigate the Potential Role of MicroRNAs in the Pathogenesis of diabetic cardiomyopathy.

SDG 0930116N (PI: Lipskaia, Larissa)
American Heart Association (AHA)
SERCA2a and vascular function
The major goal of this project is to assess the role of SERCA2a in the control of vascular smooth cells proliferation and post-injury restenosis.