Gastrointestinal Cancer Research Program

Steven Itzkowitz, MD, conducts clinical and translational studies focused on gastrointestinal cancer. Translational studies are exploring the possible impact of the gut microbiome on patients who have primary sclerosing cholangitis, an inflammatory condition of the bile ducts that is often associated with inflammatory bowel disease (IBD).

His team was part of the earliest efforts to develop non-invasive, stool-based tests for the detection of colorectal cancer and precancerous polyps, the latest version of which is now commercially available and included in colon cancer screening guidelines. He served as the national Principal Investigator of a clinical trial to test a stool DNA screening test in patients with IBD who are at high risk of developing colorectal cancer.  He is currently leading a multicenter study designed to explore whether patients with IBD who have a history of cancer are at increased risk for recurrent or new cancers by virtue of the medicines they are taking for their IBD.

Dr. Itzkowitz spearheaded community outreach efforts to raise awareness of colon cancer in East Harlem. He and his colleagues have demonstrated the effectiveness of using patient navigators and other system improvements to increase screening colonoscopy rates among minority individuals, and demonstrated the cost-effectiveness of this approach. He served as Co-Chair of the New York Citywide Colon Cancer Control Coalition, a consortium that demonstrated the feasibility of increasing overall screening rates while also eliminating ethnic disparities in  screening colonoscopy across New York City.

Torres J, Bao X, Goel A, Colombel JF, Pekow J, Jabri B, Williams KM, Castillo A, Odin JA, Meckel K, Fasihuddin F, Peter I, Itzkowitz S, Hu J. The features of mucosa-associated microbiota in primary sclerosing cholangitis. Alimentary pharmacology & therapeutics 2016 Apr; 43(7).

Itzkowitz SH, Winawer SJ, Krauskopf M, Carlesimo M, Schnoll-Sussman FH, Huang K, Weber TK, Jandorf L. New York Citywide Colon Cancer Control Coalition: A public health effort to increase colon cancer screening and address health disparities. Cancer 2016 Jan; 122(2).

Axelrad J, Bernheim O, Colombel JF, Malerba S, Ananthakrishnan A, Yajnik V, Hoffman G, Agrawal M, Lukin D, Desai A, McEachern E, Bosworth B, Scherl E, Reyes A, Zaidi H, Mudireddy P, DiCaprio D, Sultan K, Korelitz B, Wang E, Williams R, Chen L, Katz S, Itzkowitz S. Risk of New or Recurrent Cancer in Patients With Inflammatory Bowel Disease and Previous Cancer Exposed to Immunosuppressive and Anti-Tumor Necrosis Factor Agents. Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association 2016 Jan; 14(1).

Ladabaum U, Mannalithara A, Jandorf L, Itzkowitz SH. Cost-effectiveness of patient navigation to increase adherence with screening colonoscopy among minority individuals. Cancer 2015 Apr; 121(7).

Beaugerie L, Itzkowitz SH. Cancers complicating inflammatory bowel disease. The New England journal of medicine 2015 Apr; 372(15).

Imperiale TF, Ransohoff DF, Itzkowitz SH, Levin TR, Lavin P, Lidgard GP, Ahlquist DA, Berger BM. Multitarget stool DNA testing for colorectal-cancer screening. The New England journal of medicine 2014 Apr; 370(14).

Lee KK, Jandorf L, Thélèmaque L, Itzkowitz SH. Colorectal neoplasia detection among black and Latino individuals undergoing screening colonoscopy: a prospective cohort study. Gastrointestinal endoscopy 2014 Mar; 79(3).

Cooks T, Pateras IS, Tarcic O, Solomon H, Schetter AJ, Wilder S, Lozano G, Pikarsky E, Forshew T, Rosenfeld N, Rozenfeld N, Harpaz N, Itzkowitz S, Harris CC, Rotter V, Gorgoulis VG, Oren M. Mutant p53 prolongs NF-κB activation and promotes chronic inflammation and inflammation-associated colorectal cancer. Cancer cell 2013 May; 23(5).

Bernheim O, Colombel JF, Ullman TA, Laharie D, Beaugerie L, Itzkowitz SH. The management of immunosuppression in patients with inflammatory bowel disease and cancer. Gut 2013 Nov; 62(11).

Jandorf L, Stossel LM, Cooperman JL, Graff Zivin J, Ladabaum U, Hall D, Thélémaque LD, Redd W, Itzkowitz SH. Cost analysis of a patient navigation system to increase screening colonoscopy adherence among urban minorities. Cancer 2013 Feb; 119(3).

Steven Itzkowitz, MD

Xiuliang Bao, PhD

Anli Chen, MD

Hisayuki Matsunaga, MD, PhD

To find our clinical trials please go here